CAS 110429-35-1

Paroxetine HCl Hemihydrate

Description:

Paroxetine HCl hemihydrate is a selective serotonin reuptake inhibitor (SSRI) primarily used in the treatment of major depressive disorder, anxiety disorders, and obsessive-compulsive disorder. It is characterized by its chemical formula, which includes a hydrochloride salt form and a hemihydrate, indicating the presence of water molecules in its crystalline structure. This compound typically appears as a white to off-white powder and is soluble in water, which facilitates its absorption in the body. Paroxetine acts by inhibiting the reuptake of serotonin in the brain, thereby increasing serotonin levels and improving mood. The hemihydrate form suggests that it contains half a molecule of water for every molecule of paroxetine hydrochloride, which can influence its stability and solubility. As with many pharmaceuticals, it is essential to handle Paroxetine HCl hemihydrate with care, adhering to safety guidelines to avoid potential side effects and interactions with other medications.

Formula: C₁₉H₁₇ClD₄FNO₃

InChI: InChI=1/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14?,17-;/m0./s1

InChI key: InChIKey=QRQSGFFISBKLMZ-YHOFXEKLSA-N

SMILES: C(OC=1C=C2C(=CC1)OCO2)[C@H]3[C@@H](CCNC3)C4=CC=C(F)C=C4.Cl.O

Synonyms:

• (-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine hydrochloride hemihydrate
• (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride (1:1)
• (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride Hemihydrate
• (4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride (1:1)
• Paroxetine-D4 Hcl
• Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride, hydrate (2:1), (3S,4R)-
• Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride, hydrate (2:1), (3S-trans)-
• Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride, hydrate (2:2:1), (3S,4R)-
• paroxetine hydrochloride Hemihydrate
• Paroxetine HCl,Hemihydrate
• PAROXETINE HYDROCHLORIDE HEMIHYDRATE: (+/-)- TRANS-PAROXETINE HYDROCHLORIDE
• (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride
• 3-(Benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluoro-phenyl)-piperidine
• Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride, hydrate (2:1), (3S,4R)- (9CI)
• (-)-(3S,4R)-Paroxetine hydrochloride hemihydrate
• BRL29060A hemihydrate
• Paroxetine hydrochloride salt hemihydrate
• aroxetine hydrochloride hemihydrate
• (3S,4R)-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride
• 1,3-benzodioxol-5-yl-[4-(4-fluorophenyl)-3-piperidinyl]methanol hydrochloride
• BRL29060 hydrochloride hemihydrate
• ParoxetineHydrochlorideHemihydrate&gt
• PAROXETINE-D4 HCL USP/EP/BP
• PAROXETINE HEMIHYDRATE, EP/BP/USP
• Paroxetine Hydrochloride (350 mg)G0D0030.972mg/mg(ai)
• PAROXETINE HYDROCHLORIDE 1/2H2O
• Paroxetine hydrochloride
• Paroxetine hydrochloride hemihydrate, 99%, selective serotonin-reuptake inhibitors (SSRIs)
• PAROXETINE-D4 HCL kf-yuwen(at)kf-chem.com
• paroxetine hydrochloride hydrate
• Paroxetine Hydrochloride (350 mg)
• Paroxetine hydrochloride hemihydrate, >=99%

Paroxetine Hydrochloride Hemihydrate

CAS: 110429-35-1, 61869-08-7, 78246-49-8

Formula: C₁₉H₂₀FNO₃·HClH₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 374.84

Ref: 3B-P1977

Paroxetine.HCl.hemihydrate, 1mg/ml in Methanol (as free base)

CAS: 110429-35-1

Color and Shape: Single Solution

Ref: LP-PRX-1254-HC-1LM

Paroxetine.HCl.hemihydrate

CAS: 110429-35-1

Color and Shape: Neat

Ref: LP-PRX-1254-HC-10

Paroxetine Hydrochloride Hemihydrate 1.0 mg/ml in Methanol (as anhydrous free base)

CAS: 110429-35-1

Color and Shape: Single Solution

Ref: 61-AMP0264.00-01

Paroxetine Hydrochloride Hemihydrate

CAS: 110429-35-1

Color and Shape: Neat

Ref: 61-FOR0264.00

Paroxetine impurity standard

CAS: 110429-35-1

Paroxetine impurity standard

Color and Shape: White

Ref: 47-746

Paroxetine hydrochloride hemihydrate

CAS: 110429-35-1

Paroxetine hydrochloride hemihydrate

Formula: C₁₉H₂₀FNO₃HCl

Purity: 97.4%

Color and Shape: Off-White

Molecular weight: 365.1194

Ref: 47-1024

PAROXETINE HYDROCHLORIDE HEMIHYDRATE CRS

CAS: 110429-35-1

PAROXETINE HYDROCHLORIDE HEMIHYDRATE CRS

Formula: C₃₈H₄₄Cl₂F₂N₂O₇

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 749.668

Ref: 41-Y0000281

PAROXETINE FOR SYSTEM SUITABILITY CRS

CAS: 110429-35-1

PAROXETINE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0000630

Paroxetine Hydrochloride

CAS: 110429-35-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₉H₂₀FNO₃·HClH₂O

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 329.14272

Ref: 45-1500218

Paroxetine Hydrochloride Hemihydrate

CAS: 110429-35-1

Paroxetine Hydrochloride Hemihydrate

Purity: 98%

Molecular weight: 374.83g/mol

Ref: 54-PC109214

Paroxetine hydrochloride hemihydrate

CAS: 110429-35-1

Paroxetine hydrochloride hemihydrate

Purity: ≥98%

Molecular weight: 749.67g/mol

Ref: 54-BUP13721

Paroxetine HCl

CAS: 110429-35-1

Formula: C₁₉H₂₀FNO₃·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 329.37 36.46

Ref: 4Z-P-021

Paroxetine hydrochloride

CAS: 110429-35-1

Formula: C₁₉H₂₀FNO₃·HCl·5(H₂O)

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: White crystalline powder

Molecular weight: 374.83

Ref: 7W-GP8602

Paroxetine Hydrochloride Hemihydrate

CAS: 110429-35-1

Color and Shape: Neat

Ref: 86-MM0264.00

Paroxetine Hydrochloride RS

CAS: 110429-35-1

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1114500021

Paroxetine Hydrochloride Hemihydrate

CAS: 110429-35-1

Formula: C₁₉H₂₀FNO₃HCl(H₂O)

Molecular weight: 329.4 : 36.46 : 1/2(18.0)

Ref: ST-EA-CP-P217000

Paroxetine HCl (hemihydrate)

Controlled Product

CAS: 110429-35-1

A serotonin reuptake inhibitor with anticholinergic activity and mild inhibitory activity on noradrenaline reuptake. Paroxetine has been used for the treatment of depression, anxiety disorders, post-traumatic stress disorder, premenstrual dysphoric disorder and obsessive-compulsive disorder.  Also inhibits nitric oxide synthase and cytochrome isoenzyme P450 2D6.

Formula: C₁₉H₂₀FNO₃•HCl•(H₂O)₀

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 374.83 g/mol

Ref: 3D-FP60426

Paroxetine HCl hemihydrate - Bio-X ™

Controlled Product

CAS: 110429-35-1

Paroxetine belongs to a class of drugs called selective serotonin reuptake inhibitors. It is used as an antidepressant and anxiolytic agent but also for post-traumatic stress disorder, premenstrual dysphoric disorder and obsessive-compulsive disorder. Paroxetine inhibits the activity of the enzyme, which is responsible for the re-uptake of serotonin in nerve cells and thus increases its concentration in the synaptic space. Additionally, it inhibits nitric oxide synthase and cytochrome isoenzyme P450 2D6.

Formula: C₁₉H₂₀FNO₃·HClH₂O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 374.83 g/mol

Ref: 3D-BP164263

USP Paroxetine Related Compound E Mixture

Controlled Product

CAS: 1012886-75-7, 110429-35-1

Applications USP Paroxetine Related Compound E Mixture is a reference standard composed of Paroxetine Hydrochloride (P205750) spiked with 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine Hydrochloride (F595220). Paroxetine Hydrochloride (P205750) is a selective serotonin reuptake inhibitor. Used as an antidepressant. 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine Hydrochloride (F595220) is the active metabolite of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (M325910), N-Methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982); Gerlach, M., et al.: Eur. J. Pharmacol., 208, 273 (1991), Tipton, K., et al.: J. Neurochem., 61, 1191 (1993), Wimalasena, D., et al.: J. Biol. Chem., 279, 15298 (2004),

Formula: C₁₉H₂₀FNO₃·C₁₂H₁₄FN·HCl

Color and Shape: Neat

Molecular weight: 557.07

Ref: TR-P205790