CAS 112573-73-6

Ecadotril

Description:

Ecadotril is a synthetic compound primarily known for its role as an antihypertensive agent. It functions as an enkephalinase inhibitor, which helps to increase the levels of endogenous enkephalins, leading to vasodilation and a reduction in blood pressure. The chemical structure of Ecadotril features a thiazolidine ring, contributing to its pharmacological properties. It is typically administered orally and has been studied for its potential benefits in treating conditions related to hypertension and heart failure. Ecadotril's mechanism of action involves the modulation of the renin-angiotensin system, which plays a crucial role in blood pressure regulation. While it has shown promise in clinical settings, its use may be limited by side effects or interactions with other medications. As with any pharmaceutical agent, the safety profile and efficacy are evaluated through clinical trials to determine its therapeutic potential and appropriate usage guidelines.

Formula: C₂₁H₂₃NO₄S

InChI: InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)/t19-/m1/s1

InChI key: InChIKey=ODUOJXZPIYUATO-LJQANCHMSA-N

SMILES: [C@H](CC1=CC=CC=C1)(C(NCC(OCC2=CC=CC=C2)=O)=O)CSC(C)=O

Synonyms:

• (S)-Acetophan
• (S)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester
• BAY-y 7432
• Bp 1.02
• Ecadotril [USAN:INN]
• Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (S)-
• Glycine, N-[(2S)-2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-, phenylmethyl ester
• N-((S)-alpha-(Mercaptomethyl)hydrocinnamoyl)glycine, benzyl ester, acetate (ester)
• N-(2-Acetylthiomethyl-1-oxo-3-phenylpropyl)glycine (S)(-)benzyl ester
• S 049
• Sinorphan
• Unii-6Xsr933Srk
• benzyl N-[(2S)-3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate

(S)-Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate

CAS: 112573-73-6

Formula: C₂₁H₂₃NO₄S

Color and Shape: Solid

Molecular weight: 385.4766

Ref: IN-DA008WGR

Sinorphan

Controlled Product

CAS: 112573-73-6

Applications Sinorphan is an inhibitor of angiotensin-converting enzyme and neutral endopeptidase.
References Sulpizio, A.C., et al.: J. Pharmacol. Exp. Therap., 209, 1141 (2004); Takeda, Y., et al.: J. Hyper., 18, 927 (2000); Monteil, T., et al.: Syn. Comm., 31, 211 (2001);

Formula: C₂₁H₂₃NO₄S

Color and Shape: Neat

Molecular weight: 385.48

Ref: TR-S490950

Sinorphan-d5

Controlled Product

CAS: 112573-73-6

Formula: C₂₁D₅H₁₈NO₄S

Color and Shape: Neat

Molecular weight: 390.507

Ref: TR-S490952

Ecadotril

CAS: 112573-73-6

Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role.

Formula: C₂₁H₂₃NO₄S

Color and Shape: Solid

Molecular weight: 385.48

Ref: TM-T31598