CAS 1226-52-4

4-hydroxytriamterene

Description:

4-Hydroxytriamterene is a chemical compound that belongs to the class of potassium-sparing diuretics, primarily used in the treatment of hypertension and edema. It is a derivative of triamterene, featuring a hydroxyl group at the fourth position of the triamterene structure. This modification enhances its solubility and biological activity. The compound acts by inhibiting sodium channels in the distal nephron of the kidney, leading to increased sodium excretion while conserving potassium. Its molecular formula typically includes carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its organic nature. 4-Hydroxytriamterene is characterized by its moderate stability under standard conditions, but it may be sensitive to light and moisture, necessitating proper storage conditions. The compound is usually administered in oral form and may have side effects, including electrolyte imbalances. As with many pharmaceuticals, its use should be monitored by healthcare professionals to ensure safety and efficacy.

Formula: C₁₂H₁₁N₇O

InChI: InChI=1/C12H11N7O/c13-9-7(5-1-3-6(20)4-2-5)16-8-10(14)18-12(15)19-11(8)17-9/h1-4,20H,(H6,13,14,15,17,18,19)

SMILES: c1cc(ccc1c1c(=N)nc2c(c(N)[nH]c(=N)[nH]2)n1)O

Synonyms:

• para-Hydroxytriamterene
• Phenol, 4-(2,4,7-triamino-6-pteridinyl)-
• 4-(2,4,7-triaminopteridin-6(5H)-ylidene)cyclohexa-2,5-dien-1-one
• 4-(2,4,7-Triaminopteridin-6-Yl)Phenol
• 4-Hydroxytriamterene

Phenol, 4-(2,4,7-triamino-6-pteridinyl)-

CAS: 1226-52-4

Formula: C₁₂H₁₁N₇O

Color and Shape: Solid

Molecular weight: 269.262

Ref: IN-DA0017IB

Hydroxy Triamterene

CAS: 1226-52-4

Formula: C₁₂H₁₁N₇O

Color and Shape: Yellow Solid

Molecular weight: 269.27

Ref: 4Z-T-6310

4-Hydroxy Triamterene

Controlled Product

CAS: 1226-52-4

Applications A metabolite of Triamterne, a diuretic agent.
References Vollmer, G., et al.: Arzneim.-Forsch., 31, 529 (1981), Gilfrich, H.J., et al.: Eur. J. Clin. Pharmacol., 25, 237 (1983),

Formula: C₁₂H₁₁N₇O

Color and Shape: Neat

Molecular weight: 269.26

Ref: TR-H971050

4-Hydroxy Triamterene-d4 Hydrochloride

Controlled Product

CAS: 1226-52-4

Applications A labelled metabolite of Triamterne, a diuretic agent.
References Vollmer, G., et al.: Arzneim.-Forsch., 31, 529 (1981), Gilfrich, H.J., et al.: Eur. J. Clin. Pharmacol., 25, 237 (1983),

Formula: C₁₂H₇D₄N₇O·HCl

Color and Shape: Neat

Molecular weight: 309.75

Ref: TR-H971052

Hydroxy Triamterene

CAS: 1226-52-4

Formula: C₁₂H₁₁N₇O

Molecular weight: 269.27

Ref: ST-EA-CP-T178007