CAS 132843-25-5

rufloxacin sulfoxide

Description:

Rufloxacin sulfoxide is a chemical compound that belongs to the class of fluoroquinolone antibiotics, which are known for their broad-spectrum antibacterial activity. It is a derivative of rufloxacin, characterized by the presence of a sulfoxide functional group, which can influence its pharmacological properties. The compound typically exhibits good solubility in organic solvents and moderate solubility in water, which can affect its bioavailability and distribution in biological systems. Rufloxacin sulfoxide is primarily used in the treatment of various bacterial infections, leveraging its mechanism of action that involves the inhibition of bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and repair. The compound may also exhibit a favorable safety profile, although potential side effects can include gastrointestinal disturbances and effects on the central nervous system. As with other fluoroquinolones, caution is advised regarding its use in certain populations, such as pregnant women and individuals with a history of tendon disorders.

Formula: C₁₇H₁₉ClFN₃O₄S

InChI: InChI=1/C17H18FN3O4S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)26(25)7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H

SMILES: CN1CCN(CC1)c1c(cc2c3c1S(=O)CCn3cc(c2=O)C(=O)O)F.Cl

Synonyms:

• 9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid 1-oxide, monohydrochloride
• Rufloxacinsulfoxide
• 7H-Pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-, 1-oxide, monohydrochloride
• 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid 1-oxide hydrochloride (1:1)