CAS 133605-57-9

pancreastatin fragment 37-52 human

Description:

Pancreastatin fragment 37-52, a peptide derived from the prohormone proglucagon, is a biologically active fragment that plays a role in glucose metabolism and regulation of insulin secretion. This peptide is known for its ability to inhibit insulin release from pancreatic beta cells, thereby influencing blood glucose levels. It is characterized by its specific amino acid sequence, which contributes to its biological activity and receptor interactions. The CAS number 133605-57-9 uniquely identifies this compound in chemical databases, facilitating its study and application in research. Pancreastatin fragment 37-52 is often investigated for its potential implications in metabolic disorders, including diabetes, due to its regulatory effects on pancreatic function. Additionally, it may exhibit other physiological effects, such as influencing gastrointestinal motility and hormone secretion. As a peptide, it is typically synthesized through solid-phase peptide synthesis or extracted from biological sources, and its stability and activity can be affected by factors such as pH and temperature.

Formula: C₇₈H₁₂₃N₂₁O₂₇S

Synonyms:

• Glu-Glu-Glu-Glu-Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly-Nh2

Chromogranin A (Human, 286-301 Amide)

CAS: 133605-57-9

Chromogranin A (Human, 286-301 Amide) is a protein that belongs to the class of peptides. It is a major component of the chromaffin granules in the adrenal medulla and in neuroendocrine cells in various parts of the brain. There are two types of chromogranin A, which have 286-301 amino acids. Chromogranin A is an activator for G-protein coupled receptors, ion channels, and ligands. This protein has been used as a research tool in Cell Biology and as an inhibitor in Pharmacology.

Formula: C₇₈H₁₂₃N₂₁O₂₇S

Purity: Min. 95%

Molecular weight: 1,819 g/mol

Ref: 3D-PCR-4214-V

Pancreastatin (33-48) (human) trifluoroacetate salt

CAS: 133605-57-9

Pancreastatin (33-48) is a synthetic, acidic, sulfated peptide that has been shown to have high activity against pancreatic cancer cells. Pancreastatin (33-48) has been synthesized by reacting an oligopeptide with glutamic acid and aspartic acid. The N-terminal of this peptide is amidated and contains a sulfate group. This molecule has been purified by SDS-polyacrylamide gel electrophoresis and the sulfate fractionation method. Pancreastatin (33-48) is able to inhibit the proliferation of pancreatic tumor cells in vitro, but it does not appear to be cytotoxic to normal pancreatic cells. In addition, pancreastatin (33-48) has also been shown to decrease tumor growth in vivo in mice bearing a transplanted human pancreatic tumor.

Formula: C₇₈H₁₂₃N₂₁O₂₇S

Purity: Min. 95%

Molecular weight: 1,819 g/mol

Ref: 3D-FP109859