CAS 151-73-5

Betamethasone sodium phosphate

Description:

Betamethasone sodium phosphate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is a white to off-white crystalline powder that is soluble in water, making it suitable for parenteral administration. This compound is the sodium salt of betamethasone phosphate, which enhances its solubility and bioavailability. Betamethasone sodium phosphate is commonly used in the treatment of various inflammatory and allergic conditions, including skin disorders, respiratory issues, and certain autoimmune diseases. Its mechanism of action involves the modulation of gene expression, leading to reduced production of inflammatory mediators. The substance is typically administered via injection or as part of topical formulations. Due to its potent effects, it is essential to use this medication under medical supervision to avoid potential side effects, such as adrenal suppression or increased susceptibility to infections. Overall, betamethasone sodium phosphate is a valuable therapeutic agent in managing a range of conditions requiring corticosteroid intervention.

Formula: C₂₂H₃₀FO₈P·2Na

InChI: InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

InChI key: InChIKey=ODEOTKLZVXBMJD-LWCNAHDDSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@H](C)[C@@]2(C(COP(=O)(O)O)=O)O)[H].[Na]

Synonyms:

• 1,4-Pregnadien-9-Alpha-Fluoro-16-Beta-Methyl-11-Beta, 17,21-Triol-3,20-Dione 21-Phosphate, Disodium Salt
• 20-Dione,9-Fluoro-11-Beta,17,21-Trihydroxy-16-Beta-Methyl-Pregna-4-Diene-3
• 21-(Dihydrogenphosphate),Disodiumsalt
• 9A-Fluoro-16B-Methylprednisolone-21-(Disodium Phosphate)
• Bentelan
• Beta Methasone Sodium Phosphate
• Betamethasone 21-(Disodium Phosphate)
• Betamethasone 21-Phosphate Disodium
• Betamethasone 21-Phosphate Disodium Salt
• Betamethasone 21-Phosphate Sodium Salt
• Betamethasone Sodium Phosphate
• Betamethasone disodium phosphate
• Betamethasonedisodiumphosphate
• Betmethasone Disodium Phosphate
• Betnesol
• Celestan
• Celestan solubile
• Disodium (11Beta,16Beta)-9-Fluoro-11,17-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl Phosphate
• Disodium betamethasone 21-phosphate
• Durabetason
• Nsc 90616
• Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,DisodiumSalt,(11Beta,16Beta)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate), disodium salt
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI)
• Steronema

Betamethasone 21-Phosphate Disodium Salt

CAS: 151-73-5, 360-63-4

Formula: C₂₂H₂₈FNa₂O₈P

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 516.41

Ref: 3B-B4110

BETAMETHASONE SODIUM PHOSPHATE RS

CAS: 151-73-5

BETAMETHASONE SODIUM PHOSPHATE RS

Formula: C₂₂H₂₈FNa₂O₈P

Molecular weight: 516.4046

Ref: 41-ICRS0229

BETAMETHASONE SODIUM PHOSPHATE CRS

CAS: 151-73-5

BETAMETHASONE SODIUM PHOSPHATE CRS

Formula: C₂₂H₂₈FNa₂O₈P

Color and Shape: White. Whitish. Powder.

Molecular weight: 516.4046

Ref: 41-B1045000

Betamethasone sodium phosphate

CAS: 151-73-5

Betamethasone sodium phosphate

Color and Shape: Off White Solid

Ref: 47-41

Betamethasone Sodium Phosphate

CAS: 151-73-5

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₂H₂₈FNa₂O₈P

Color and Shape: White Off-White Powder Crystalline Solid

Molecular weight: 516.13012

Ref: 45-1068004

Betamethasone 21-disodium phosphate

CAS: 151-73-5

Formula: C₂₂H₂₈FNa₂O₈P

Purity: 97%

Color and Shape: Solid

Molecular weight: 516.4046

Ref: IN-DA003O6B

Betamethasone 21-phosphate disodium, Ph. Eur. grade

CAS: 151-73-5

Formula: C₂₂H₂₈FNa₂O₈P

Molecular weight: 516.40

Ref: 7W-GK0692

Vista-Methasone

CAS: 151-73-5

Vista-Methasone

Purity: 97%

Molecular weight: 516.41g/mol

Ref: 54-PC109224

Betamethasone disodium phosphate

CAS: 151-73-5

Betamethasone disodium phosphate

Purity: ≥98%

Molecular weight: 516.41g/mol

Ref: 54-BUP17318

Betamethasone Sodium Phosphate

Controlled Product

CAS: 151-73-5

Formula: C₂₂H₂₈FO₈PNa

Color and Shape: Neat

Molecular weight: 516.40

Ref: 86-MM0303.00

Betamethasone 21-phosphate disodium

CAS: 151-73-5

Formula: C₂₂H₂₈FNa₂O₈P

Purity: 98.0 - 102.0 % (anhydrous)

Color and Shape: White to off-white powder

Molecular weight: 516.40

Ref: 7W-GK8107

Betamethasone-4,6,6,20,20-d5 21-PhosphateDisodium Salt

CAS: 151-73-5

Formula: C₂₂H₂₃D₅FNa₂O₈P₂

Molecular weight: 475.46 2 22.99

Ref: 4Z-B-065035

Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B Disodium Salt)

CAS: 151-73-5

Formula: C₂₂H₂₈FNa₂O₈P

Molecular weight: 470.43 2 22.99

Ref: 4Z-B-065046

Betamethasone Sodium Phosphate RS

CAS: 151-73-5

Color and Shape: White To Almost White Solid Crystal To Powder

Ref: 2K-1148000021

Dexamethasone Sodium phosphate EP Impurity B

CAS: 151-73-5

Formula: C₂₂H₂₈FO₈PNa

Molecular weight: 470.43 : 2(23.0)

Ref: ST-EA-CP-D105002

Betamethasone disodium phosphate

CAS: 151-73-5

Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) has anti-inflammatory activity and may be used in the study of rheumatoid arthritis.

Formula: C₂₂H₂₈FNa₂O₈P

Purity: 99.37%

Color and Shape: White Powder

Molecular weight: 516.41

Ref: TM-T20763

Betamethasone 21-Phosphate Disodium Salt

Controlled Product

CAS: 151-73-5

Impurity Dexamethasone Sodium Phosphate EP Impurity B
Stability Hygroscopic
Applications Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.
References Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Seidler, J., et al.: J. Med. Chem., 46, 4477 (2003), Alsenz, J., et al.: J. Pharm. Sci., 96, 1748 (2007),

Formula: C₂₂H₂₈FO₈P·2Na

Color and Shape: White To Off-White

Molecular weight: 516.40

Ref: TR-B327030

Betamethasone 21-phosphate disodium

CAS: 151-73-5

Betamethasone 21-phosphate disodium is a synthetic glucocorticoid, which is a man-made analog of naturally occurring steroid hormones produced in the adrenal cortex. Its molecular structure allows for enhanced potency and solubility, making it highly effective for use in various clinical settings. As a glucocorticoid, Betamethasone 21-phosphate disodium functions by binding to glucocorticoid receptors, regulating the expression of anti-inflammatory proteins, and inhibiting the production of pro-inflammatory cytokines. This mechanism of action reduces inflammation and suppresses the immune response, making it valuable in the treatment of conditions that involve excessive inflammation. It is commonly used in the management of conditions such as allergic reactions, certain types of arthritis, and skin diseases. Its ability to rapidly modulate inflammatory pathways also makes it useful in emergency settings for conditions like acute asthma exacerbations and severe allergic reactions. As a water-soluble ester, it allows for diverse administration routes, including oral, intravenous, and topical applications, depending on the clinical requirement.

Formula: C₂₂H₂₈FNa₂O₈P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 516.4 g/mol

Ref: 3D-FB18567

Betamethasone disodium phosphate

CAS: 151-73-5

Purity: 97%

Molecular weight: 516.41

Ref: 10-F986710

Betamethasone Sodium Phosphate Impurity 1

CAS: 151-73-5

Formula: C₂₂H₂₈FO₈P(Na)

Molecular weight: 470.43 : 2(23.0)

Ref: ST-EA-CP-B92010