CAS 168079-32-1

Lixivaptan

Description:

Lixivaptan is a selective vasopressin V2 receptor antagonist, primarily used in the treatment of conditions associated with excessive vasopressin, such as hyponatremia and certain forms of heart failure. It functions by inhibiting the action of vasopressin on the kidneys, leading to increased water excretion without significant electrolyte loss. This mechanism helps to correct fluid imbalances in patients. Lixivaptan is characterized by its chemical structure, which includes a specific arrangement of atoms that contributes to its pharmacological activity. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. The substance is also noted for its relatively low potential for drug interactions, making it a suitable option for patients on multiple medications. As with any medication, potential side effects may include dehydration, hypotension, and electrolyte imbalances, necessitating careful monitoring during treatment. Overall, lixivaptan represents a targeted approach to managing disorders related to vasopressin dysregulation.

Formula: C₂₇H₂₁ClFN₃O₂

InChI: InChI=1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)

InChI key: InChIKey=PPHTXRNHTVLQED-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(CN3C(C1)=CC=C3)=CC=CC2)C4=C(Cl)C=C(NC(=O)C5=C(C)C=CC(F)=C5)C=C4

Synonyms:

• Benzamide, N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-
• N-[3-Chloro-4-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
• N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
• Vpa-985
• Way-Vpa-985
• Lixivaptan

Benzamide, N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-

CAS: 168079-32-1

Formula: C₂₇H₂₁ClFN₃O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 473.9259

Ref: IN-DA001XSI

N-(3-Chloro-4-(10,11-Dihydro-5H-Benzo[e]Pyrrolo[1,2-a][1,4]Diazepine-10-Carbonyl)Phenyl)-5-Fluoro-2-Methylbenzamide

CAS: 168079-32-1

N-(3-Chloro-4-(10,11-Dihydro-5H-Benzo[e]Pyrrolo[1,2-a][1,4]Diazepine-10-Carbonyl)Phenyl)-5-Fluoro-2-Methylbenzamide

Formula: C₂₇H₂₁ClFN₃O₂

Purity: 99%

Molecular weight: 473.93

Ref: 54-PC108623

LIXIVAPTAN

CAS: 168079-32-1

LIXIVAPTAN

Formula: C₂₇H₂₁ClFN₃O₂

Purity: ≥98%

Molecular weight: 473.93

Ref: 54-BUP03639

Lixivaptan

CAS: 168079-32-1

N-(3-Chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)phenyl)-5-fluoro-2-methylbenzamide

Formula: C₂₇H₂₁ClFN₃O₂

Purity: 99%

Molecular weight: 473.93

Ref: IN-DG187959

LIXIVAPTAN

CAS: 168079-32-1

Lixivaptan (VPA-985) is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM)

Formula: C₂₇H₂₁ClFN₃O₂

Purity: 98.36%

Color and Shape: Solid

Molecular weight: 473.93

Ref: TM-T7303

Lixivaptan

Controlled Product

CAS: 168079-32-1

Applications Drug used in the treatment and prevention of cardiovascular diseases.
References Lo, R., et al.: Curr. Clin. Pharmacol., 3, 156 (2008), Ghali, J., et al.: Cardiol., 111, 147 (2008),

Formula: C₂₇H₂₁ClFN₃O₂

Color and Shape: Neat

Molecular weight: 473.93

Ref: TR-L469275

Lixivaptan

CAS: 168079-32-1

Selective vasopressin receptor V2 agonist

Formula: C₂₇H₂₁ClFN₃O₂

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 473.93 g/mol

Ref: 3D-FL24915

LIXIVAPTAN

CAS: 168079-32-1

Purity: 99%

Molecular weight: 473.9299927

Ref: 10-F811907