CAS 2140-72-9

2′-O-Methylcytidine

Description:

2′-O-Methylcytidine is a modified nucleoside that plays a significant role in various biological processes, particularly in RNA biology. It is characterized by the presence of a methyl group at the 2′ position of the ribose sugar moiety of cytidine, which enhances the stability of RNA molecules and influences their interactions with proteins and other nucleic acids. This modification is commonly found in the structure of certain tRNAs and rRNAs, contributing to their functional integrity and efficiency. The presence of the methyl group can also affect the base pairing properties and the overall conformation of RNA, impacting processes such as translation and gene regulation. 2′-O-Methylcytidine is often utilized in research and therapeutic applications, including the development of RNA-based drugs and vaccines, due to its ability to modulate immune responses and improve the pharmacokinetic properties of oligonucleotides. Its CAS number, 2140-72-9, is a unique identifier that facilitates the cataloging and study of this compound in scientific literature and databases.

Formula: C₁₀H₁₅N₃O₅

InChI: InChI=1/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7+,8+,9-/m1/s1

InChI key: InChIKey=RFCQJGFZUQFYRF-ZOQUXTDFSA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Synonyms:

• Cytidine, 2′-O-methyl-
• O2′-Methylcytidine
• 2′-O-Methylcytidine
• 4-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
• 2'-O-Methylcytidineanhydrous
• 2''-(O-METHYL)-CYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM
• 2'-O-Methyl-D-cytidine

2'-O-Methylcytidine

CAS: 2140-72-9

Formula: C₁₀H₁₅N₃O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 257.25

Ref: 3B-M2317

2'-O-Methylcytidine, 99%

CAS: 2140-72-9

2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand

Formula: C₁₀H₁₅N₃O₅

Purity: 99%

Molecular weight: 257.24

Ref: 02-J65528

Cytidine, 2'-​O-​methyl-

CAS: 2140-72-9

Formula: C₁₀H₁₅N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 257.2432

Ref: IN-DA00I44O

2''-O-Methylcytidine

CAS: 2140-72-9

Formula: C₁₀H₁₅N₃O₅

Molecular weight: 257.24

Ref: 7W-GE9294

2’-O-Methylcytidine

CAS: 2140-72-9

2’-O-Methylcytidine

Purity: 98%

Molecular weight: 257.24g/mol

Ref: 54-OR1010238

2′-O-Methylcytidine

CAS: 2140-72-9

2′-O-Methylcytidine

Purity: ≥98%

Molecular weight: 257.24g/mol

Ref: 54-BUP17963

2′-O-Methylcytidine

CAS: 2140-72-9

2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

Formula: C₁₀H₁₅N₃O₅

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 257.24

Ref: TM-T38237

2’-O-Methyl Cytidine

Controlled Product

CAS: 2140-72-9

Applications Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Formula: C₁₀H₁₅N₃O₅

Color and Shape: White

Molecular weight: 257.24

Ref: TR-M294660

2'-O-Methyl-d3 Cytidine

Controlled Product

CAS: 2140-72-9

Applications 2’-O-Methyl-d3 Cytidine is an isotopic labeled cytidine(M294660) analog. 2’-O-Methyl Cytidine is used for the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B.

Formula: C₁₀H₁₂D₃N₃O₅

Color and Shape: White To Off-White

Molecular weight: 260.26

Ref: TR-M294662

2'-O-Methylcytidine

CAS: 2140-72-9

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon. The hydroxyl group makes it an effective inhibitor of viral replication, and it has been shown to be active against HIV-1 in cell culture. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways, and the metabolic response can be studied using proton nuclear magnetic resonance (NMR) spectroscopy and x-ray diffraction data. It has been found that 2'-O-Methylcytidine inhibits protein synthesis in cancer cells, and this may be due to its ability to bind to the response element on DNA.

Formula: C₁₀H₁₅N₃O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 257.24 g/mol

Ref: 3D-NM06302

2′-O-Methylcytidine

CAS: 2140-72-9

Formula: C₁₀H₁₅N₃O₅

Purity: 95%

Color and Shape: Solid, Crystalline Powder

Molecular weight: 257.246

Ref: 10-F219012

2'-O-Methylcytidine

CAS: 2140-72-9

Cis-2'-O-methylcytidine is a modified nucleoside that has shown antiviral and anticancer activity. It is a monophosphate analog of cytidine with high antiviral activity against HIV, HSV-1, HSV-2, EBV, and CMV. Cis-2'-O-methylcytidine also inhibits tumor growth in mice by inhibiting the synthesis of DNA. Cis-2'-O-methylcytidine has been synthesized from ribonucleosides and deoxyribonucleosides to provide high purity and quality.

Formula: C₁₀H₁₅N₃O₅

Molecular weight: 257.24 g/mol

Ref: 3D-J-700064