CAS 55096-26-9

Nalmefene

Description:

Nalmefene is a synthetic opioid receptor modulator primarily used in the treatment of alcohol dependence. It acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor, which contributes to its unique pharmacological profile. Nalmefene is characterized by its ability to reduce alcohol consumption and cravings without producing significant euphoric effects, making it distinct from other opioids. The chemical structure of nalmefene includes a phenolic hydroxyl group, which is crucial for its activity. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Nalmefene's safety profile includes potential side effects such as nausea, dizziness, and insomnia, but it is generally well-tolerated. Due to its mechanism of action, nalmefene is considered a valuable option in the management of alcohol use disorder, particularly for individuals who wish to reduce their alcohol intake rather than achieve complete abstinence.

Formula: C₂₁H₂₅NO₃

InChI: InChI=1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1

InChI key: InChIKey=WJBLNOPPDWQMCH-MBPVOVBZSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=C)CC1)[H])=C(O)C=CC5C[C@]2(N(CC6CC6)CC4)[H]

Synonyms:

• (5Alpha)-17-(Cyclopropylmethyl)-6-Methylidene-4,5-Epoxymorphinan-3,14-Diol
• (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol
• (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
• 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol
• 6-Deoxo-6-methylenenaltrexone
• 6-Desoxy-6-methylenenaltrexone
• 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
• Alcofene
• Arthene
• Cervene
• Cessal
• Fenarc
• Hsdb 6761
• Incystene
• Jf 1
• Jkb 121
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5alpha)-
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5α)-
• Nalmefene [USAN:INN:BAN]
• Nalmefeno
• Nalmefeno [INN-Spanish]
• Nalmefenum
• Nalmefenum [INN-Latin]
• Nalmetrene
• Nalmetreno
• Nalmetreno [INN-Spanish]
• Nalmetrenum
• Nalmetrenum [INN-Latin]
• Nocarex
• Orf 11676
• Soberal
• Srd 174
• Unii-Tov02Tdp9I

Nalmefene

CAS: 55096-26-9

Formula: C₂₁H₂₅NO₃

Purity: ≥ 98%

Color and Shape: White to off-white or light-yellow powder

Molecular weight: 339.43

Ref: 7W-GP5746

Nalmefene

CAS: 55096-26-9

Nalmefene

Purity: ≥98%

Molecular weight: 339.43g/mol

Ref: 54-BUP06658

Nalmefene-d4

CAS: 55096-26-9

Formula: C₂₁H₂₁D₄NO₃

Molecular weight: 343.46

Ref: 4Z-N-504

Nalmefene

CAS: 55096-26-9

Formula: C₂₁H₂₅NO₃

Color and Shape: Pale Yellow Solid

Molecular weight: 339.44

Ref: 4Z-N-5021

Nalmefene-3-O-Glucuronide

Controlled Product

CAS: 55096-26-9

Formula: C₂₇H₃₃NO₉

Color and Shape: Neat

Molecular weight: 513.54

Ref: TR-N284410

Nalmefene-d3

Controlled Product

CAS: 55096-26-9

Applications A structural labelled analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist.
References Brittain, H.G., et al.: Anal. Profiles Drug Subs. Excip., 24, 351 (1996), Anton, R., et al.: J. Clin. Psychopharmacol., 24, 421 (2004), Bart, G., et al.: Neuropsychopharmacol., 30, 2254 (2005), Wu, X., et al.: Chem. Pharmacol. Bull., 54, 977 (2006),

Formula: C₂₁H₂₂D₃NO₃

Color and Shape: Neat

Molecular weight: 342.45

Ref: TR-N284402

Nalmefene

Controlled Product

CAS: 55096-26-9

Formula: C₂₁H₂₅NO₃

Color and Shape: White To Light Beige

Molecular weight: 339.43

Ref: TR-N284400

Nalmefene

Controlled Product

CAS: 55096-26-9

μ- and κ- opioid receptor antagonist; partial agonist of δ- opioid receptors

Formula: C₂₁H₂₅NO₃

Purity: Min. 95%

Molecular weight: 339.43 g/mol

Ref: 3D-BN36715

Nalmefene

CAS: 55096-26-9

Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.

Formula: C₂₁H₂₅NO₃

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 339.43

Ref: TM-T86954