CAS 55096-26-9: Nalmefene

Description: Nalmefene is a synthetic opioid receptor modulator primarily used in the treatment of alcohol dependence. It acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor, which contributes to its unique pharmacological profile. Nalmefene is characterized by its ability to reduce alcohol consumption and cravings without producing significant euphoric effects, making it distinct from other opioids. The chemical structure of nalmefene includes a phenolic hydroxyl group, which is crucial for its activity. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Nalmefene's safety profile includes potential side effects such as nausea, dizziness, and insomnia, but it is generally well-tolerated. Due to its mechanism of action, nalmefene is considered a valuable option in the management of alcohol use disorder, particularly for individuals who wish to reduce their alcohol intake rather than achieve complete abstinence.

Formula: C₂₁H₂₅NO₃

InChI: InChI=1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1

InChI key: InChIKey=WJBLNOPPDWQMCH-MBPVOVBZSA-N

SMILES: OC1=CC=C2C3=C1OC4C(=C)CCC5(O)C(N(CCC345)CC6CC6)C2

Synonyms:

• (5Alpha)-17-(Cyclopropylmethyl)-6-Methylidene-4,5-Epoxymorphinan-3,14-Diol
• (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol
• (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
• 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol
• 6-Deoxo-6-methylenenaltrexone
• 6-Desoxy-6-methylenenaltrexone
• 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
• Alcofene
• Arthene
• Cervene
• Cessal
• Fenarc
• Hsdb 6761
• Incystene
• Jf 1
• Jkb 121
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5alpha)-
• Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5α)-
• Nalmefene [USAN:INN:BAN]
• Nalmefeno
• Nalmefeno [INN-Spanish]
• Nalmefenum
• Nalmefenum [INN-Latin]
• Nalmetrene
• Nalmetreno
• Nalmetreno [INN-Spanish]
• Nalmetrenum
• Nalmetrenum [INN-Latin]
• Nocarex
• Orf 11676
• Soberal
• Srd 174
• Unii-Tov02Tdp9I
• Nalmefene

Nalmefene

CAS: 55096-26-9

• Formula: C₂₁H₂₅NO₃
• Purity: ≥ 98%
• Color and Shape: White to off-white or light-yellow powder
• Molecular weight: 339.43

Nalmefene

CAS: 55096-26-9

• Molecular weight: 339.43g/mol

Nalmefene-d4

CAS: 55096-26-9

• Formula: C₂₁H₂₁D₄NO₃
• Molecular weight: 343.46

Nalmefene

CAS: 55096-26-9

• Formula: C₂₁H₂₅NO₃
• Color and Shape: Pale Yellow Solid
• Molecular weight: 339.44

Nalmefene-3-O-Glucuronide

CAS: 55096-26-9

• Formula: C₂₇H₃₁NO₉
• Color and Shape: Neat
• Molecular weight: 513.54

Nalmefene-d3

CAS: 55096-26-9

Applications A structural labelled analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical …

• Formula: C₂₁H₂₂D₃NO₃
• Color and Shape: Neat
• Molecular weight: 342.45

Nalmefene

CAS: 55096-26-9

• Formula: C₂₁H₂₅NO₃
• Color and Shape: White To Light Beige
• Molecular weight: 339.43

Nalmefene

CAS: 55096-26-9

μ- and κ- opioid receptor antagonist; partial agonist of δ- opioid receptors

• Formula: C₂₁H₂₅NO₃
• Purity: Min. 95%
• Molecular weight: 339.43 g/mol

Nalmefene

CAS: 55096-26-9

Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study …

• Formula: C₂₁H₂₅NO₃
• Purity: 99.86%
• Color and Shape: Liquid
• Molecular weight: 339.43