CAS 553-53-7

Nicotinic acid, hydrazide

Description:

Nicotinic acid hydrazide, also known as isonicotinic acid hydrazide (INH), is a chemical compound with the CAS number 553-53-7. It is a hydrazide derivative of nicotinic acid, characterized by its white crystalline appearance and moderate solubility in water and organic solvents. This compound is primarily recognized for its role as an antitubercular agent, commonly used in the treatment of tuberculosis due to its ability to inhibit the synthesis of mycolic acids in bacterial cell walls. Nicotinic acid hydrazide exhibits a range of biological activities, including potential anti-inflammatory and antioxidant properties. Its molecular structure features a hydrazide functional group, which contributes to its reactivity and biological interactions. The compound is typically administered in a pharmaceutical context, and its safety profile is well-studied, although it may have side effects that require monitoring during treatment. Overall, nicotinic acid hydrazide is an important compound in medicinal chemistry, particularly in the context of infectious disease management.

Formula: C₆H₇N₃O

InChI: InChI=1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10)

InChI key: InChIKey=KFUSANSHCADHNJ-UHFFFAOYSA-N

SMILES: C(NN)(=O)C=1C=CC=NC1

Synonyms:

• (3-Pyridylcarbonyl)Hydrazine
• 3-Nicotinohydrazide
• 3-Pyridine-Carbonylhydrazine
• 3-Pyridinecarbohydrazide
• 3-Pyridinecarboxylic acid, hydrazide
• 3-Pyridinecarboxylic hydrazide
• 3-Pyridinecarboxylicacid,Hydrazide
• 3-Pyridoyl Hydrazine
• 3-Pyridoylhydrazine
• 3-Pyridylcarbonylhydrazine
• Hydrazine, nicotinoyl-
• INHd 37
• N-Aminopyridine-3-carboxamide
• NSC 18775
• NSC 36088
• NSC 41703
• Niazid
• Nicotinic Acid Hydrazide
• Nicotinohydrazide
• Nicotinoyl hydrazide
• Nicotinoylhydrazine
• Nicotinyl hydrazide
• Nicotinylhydrazine

Nicotinic Acid Hydrazide

CAS: 553-53-7

Formula: C₆H₇N₃O

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 137.14

Ref: 3B-N0087

Nicotinic acid hydrazide

CAS: 553-53-7

NAH, a nicotinic acid hydrazide derivative, inhibits peroxidase and forms bioactive metal complexes.

Formula: C₆H₇N₃O

Purity: 97.79%

Color and Shape: White To Off-White Fine Needle-Like Cryst Powder

Molecular weight: 137.14

Ref: TM-T0664

3-​Pyridinecarboxylic acid, hydrazide

CAS: 553-53-7

Formula: C₆H₇N₃O

Purity: 97%

Color and Shape: Solid

Molecular weight: 137.1393

Ref: IN-DA003T3R

Pyridine-3-carbohydrazide

CAS: 553-53-7

Pyridine-3-carbohydrazide

Formula: C₆H₇N₃O

Purity: 97%

Color and Shape: faint beige powder

Molecular weight: 137.14g/mol

Ref: 54-OR21092

Pyridine-3-carbohydrazide

CAS: 553-53-7

Pyridine-3-carbohydrazide

Formula: C₆H₇N₃O

Purity: tech

Color and Shape: white crystalline needles

Molecular weight: 137.14g/mol

Ref: 54-OR72208

Nicotinic acid hydrazide

CAS: 553-53-7

Nicotinic acid hydrazide

Purity: ≥95%

Molecular weight: 137.14g/mol

Ref: 54-BUP19177

Isoniazid EP Impurity D

CAS: 553-53-7

Formula: C₆H₇N₃O

Molecular weight: 137.14

Ref: 4Z-I-227

3-Isoniazid

CAS: 553-53-7

3-Isoniazid is a drug used to treat bowel disease. It inhibits the synthesis of purines and pyrimidines in bacteria and has been shown to be effective against some forms of tuberculosis. 3-Isoniazid binds to inhibitor molecules, which are enzymes that are required for the synthesis of nucleic acids in bacteria, leading to their inhibition. 3-Isoniazid also blocks receptor activity in bacteria, inhibiting their ability to bind to host cells and invade tissues. The reaction mechanism for 3-isoniazid is steric interactions with the enzyme molecule, which are electrochemical interactions that lead to an increase in the repulsion between the electron clouds around the molecule's atoms. The rotarod test can be used as a screening tool for 3-isoniazid toxicity by measuring motor function on a rotating rod while under its influence. The polymerase chain can be inhibited by 3-isoniazid due to its structural analysis and intermolecular hydrogen bonding properties

Formula: C₆H₇N₃O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 137.14 g/mol

Ref: 3D-FI24684

Nicotinic Acid.Hydrazide

CAS: 553-53-7

M02155 - Nicotinic Acid.Hydrazide

Formula: C₆H₇N₃O

Purity: 97%

Color and Shape: Solid, Beige powder

Molecular weight: 137.142

Ref: 10-M02155

3-Isoniazid

Controlled Product

CAS: 553-53-7

Applications An impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.
References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Andrade, C., et al.: Lett. Drug. Des. Discov., 5, 377 (2008)

Formula: C₆H₇N₃O

Color and Shape: Off White Powder

Molecular weight: 137.14

Ref: TR-I821460