CAS 59-05-2: Methotrexate

Description: Methotrexate is a potent antimetabolite and immunosuppressive agent primarily used in the treatment of certain cancers, autoimmune diseases, and ectopic pregnancies. Its chemical formula is C20H22N8O5S, and it features a pteridine ring structure, which is crucial for its mechanism of action. Methotrexate functions by inhibiting the enzyme dihydrofolate reductase, thereby disrupting the synthesis of nucleotides and ultimately affecting DNA replication and cell division. This makes it particularly effective against rapidly dividing cells, such as those found in tumors. Methotrexate is administered in various forms, including oral tablets and injectable solutions, and its pharmacokinetics can vary based on the route of administration. The drug is known for its potential side effects, which can include gastrointestinal disturbances, liver toxicity, and bone marrow suppression. Due to its immunosuppressive properties, careful monitoring is essential during treatment to manage adverse effects and interactions with other medications. Methotrexate's use in lower doses for autoimmune conditions highlights its versatility in clinical applications.

Formula: C₂₀H₂₂N₈O₅

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChI key: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N

SMILES: O=C(O)CCC(NC(=O)C1=CC=C(C=C1)N(C)CC=2N=C3C(=NC2)N=C(N=C3N)N)C(=O)O

Synonyms:

• (+)-4-Amino-10-Methylfolic Acid
• (+)-Amethopterin
• (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-1
• 4-Amino-4-Deoxy-N(Sup10
• 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
• 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
• 4-Amino-N10-methylfolic acid
• 4-Amino-N10-methylpteroylglutamic acid
• 4-Amino-N¹⁰-methylfolic acid
• 4-Amino-N¹⁰-methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Amethopterin
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Methotrexate
• Amethopterine
• Antifolan
• Caditrex
• Cl 14377
• Emt 25299
• Emtexate
• Emthexate PF
• Emtrexate
• Folex
• Folex PFS
• Folitrax
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
• Jylamvo
• L-(+)-Amethopterin
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Methotrexate
• Ledertrexate
• Merex
• Metatrexan
• Methocel
• Methocip
• Methotrexat
• Methotrexat-Ebewe
• Methotrexate LPF
• Methoxtrexate
• Methylaminopterin
• Methylaminopterine
• Methylpteroylglutamate
• Methylpteroylglutamic Acid
• Metorex
• Metotrexato
• Mexate
• Mexate-AQ
• Mtx
• N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
• Nordimet
• Nsc 740
• Oncotrex
• R 9985
• Remtrex
• Rheumatrex
• Trexall
• Trilem
• Zexate

Methotrexate Hydrate

CAS: 133073-73-1 59-05-2

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purity: >98.0%(T)(HPLC)
• Color and Shape: Light yellow to Brown powder to crystal
• Molecular weight: 454.45 (as Anhydrous)

Methotrexate

CAS: 59-05-2

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used …

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Yellow or yellow-orange, Powder or crystalline powder
• Molecular weight: 454.45

Methotrexate CRS

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Crystalline Powder. Yellow. Orange. Powder.
• Molecular weight: 454.4393

Methotrexate RS

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Molecular weight: 454.4393

Methotrexate for peak identification CRS

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Molecular weight: 454.4393

Methotrexate

CAS: 59-05-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Yellow Brown Orange Powder
• Molecular weight: 454.17132

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 454.4393

Methotrexate

CAS: 59-05-2

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.

• Formula: C₂₀H₂₂N₈O₅
• Purity: 96.84% - 99.46%
• Color and Shape: Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna Synthesis
• Molecular weight: 454.44

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Yellow Solid
• Molecular weight: 454.45

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Purity: By hplc: 98.13% (Typical Value in Batch COA)
• Color and Shape: yellow solid
• Molecular weight: 454.44g/mol

Methotrexate

CAS: 59-05-2

• Purity: 99%
• Molecular weight: 454.44g/mol

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Neat
• Molecular weight: 454.44

Methotrexate

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Neat
• Molecular weight: 454.44

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

• Formula: C₅₀H₆₄N₁₄O₂₃·C₂HF₃O₂
• Molecular weight: 1229.14

Methotrexate RS

CAS: 59-05-2

• Color and Shape: From Yellow To Brownish Orange Solid Powder

Methotrexate

CAS: 59-05-2

Stability Hygroscopic Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic. Not a …

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Yellow To Dark Yellow
• Molecular weight: 454.44

Methotrexate-d3 Heptaglutamate Trifluoroacetate

CAS: 432545-63-6 59-05-2

• Formula: C₅₀H₆₁D₃N₁₄O₂₃xC₂HF₃O₂
• Color and Shape: Neat
• Molecular weight: 1232.142

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

• Formula: C₅₀H₆₄N₁₄O₂₃xC₂HF₃O₂
• Color and Shape: Neat
• Molecular weight: 1229.12

Methotrexate (1.0mg/mL in Methanol with 0.1N NaOH)

CAS: 59-05-2

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Single Solution
• Molecular weight: 454.44

Methotrexate

CAS: 59-05-2

Please enquire for more information about Methotrexate including the price, delivery time and more detailed …

• Formula: C₂₀H₂₂N₈O₅
• Color and Shape: Yellow Powder
• Molecular weight: 454.44 g/mol