CAS 59-05-2
:Methotrexate
Description:
Methotrexate is a potent antimetabolite and immunosuppressive agent primarily used in the treatment of certain cancers, autoimmune diseases, and ectopic pregnancies. Its chemical formula is C20H22N8O5S, and it features a pteridine ring structure, which is crucial for its mechanism of action. Methotrexate functions by inhibiting the enzyme dihydrofolate reductase, thereby disrupting the synthesis of nucleotides and ultimately affecting DNA replication and cell division. This makes it particularly effective against rapidly dividing cells, such as those found in tumors. Methotrexate is administered in various forms, including oral tablets and injectable solutions, and its pharmacokinetics can vary based on the route of administration. The drug is known for its potential side effects, which can include gastrointestinal disturbances, liver toxicity, and bone marrow suppression. Due to its immunosuppressive properties, careful monitoring is essential during treatment to manage adverse effects and interactions with other medications. Methotrexate's use in lower doses for autoimmune conditions highlights its versatility in clinical applications.
Formula:C20H22N8O5
InChI:InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChI key:InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES:NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
Synonyms:- (+)-4-Amino-10-Methylfolic Acid
- (+)-Amethopterin
- (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
- 4-Amino-1
- 4-Amino-4-Deoxy-N(Sup10
- 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
- 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
- 4-Amino-N10-methylfolic acid
- 4-Amino-N10-methylpteroylglutamic acid
- 4-Amino-N<sup>10</sup>-methylfolic acid
- 4-Amino-N<sup>10</sup>-methylpteroylglutamic acid
- <span class="text-smallcaps">L</span>-Amethopterin
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
- <span class="text-smallcaps">L</span>-Methotrexate
- Amethopterine
- Antifolan
- Caditrex
- Cl 14377
- Emt 25299
- Emtexate
- Emthexate PF
- Emtrexate
- Folex
- Folex PFS
- Folitrax
- Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
- Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
- Jylamvo
- L-(+)-Amethopterin
- L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
- L-Methotrexate
- Ledertrexate
- Merex
- Metatrexan
- Methocel
- Methocip
- Methotrexat
- Methotrexat-Ebewe
- Methotrexate LPF
- Methoxtrexate
- Methylaminopterin
- Methylaminopterine
- Methylpteroylglutamate
- Methylpteroylglutamic Acid
- Metorex
- Metotrexato
- Mexate
- Mexate-AQ
- Mtx
- N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
- N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
- N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
- N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
- Nordimet
- Nsc 740
- Oncotrex
- R 9985
- Remtrex
- Rheumatrex
- Trexall
- Trilem
- See more synonyms
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Methotrexate Hydrate
CAS:Formula:C20H22N8O5·xH2OPurity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:454.45 (as Anhydrous)Methotrexate
CAS:<p>Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely use</p>Formula:C20H22N8O5Color and Shape:Yellow or yellow-orange, Powder or crystalline powderMolecular weight:454.45METHOTREXATE FOR PEAK IDENTIFICATION CRS
CAS:<p>METHOTREXATE FOR PEAK IDENTIFICATION CRS</p>Formula:C20H22N8O5Molecular weight:454.4393METHOTREXATE CRS
CAS:<p>METHOTREXATE CRS</p>Formula:C20H22N8O5Color and Shape:Crystalline Powder. Yellow. Orange. Powder.Molecular weight:454.4393Methotrexate
CAS:<p>Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure</p>Formula:C20H22N8O5Color and Shape:Yellow Brown Orange PowderMolecular weight:454.17132(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid
CAS:Formula:C20H22N8O5Purity:97%Color and Shape:SolidMolecular weight:454.4393Methotrexate
CAS:<p>Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.</p>Formula:C20H22N8O5Purity:96.84% - 99.91%Color and Shape:Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna SynthesisMolecular weight:454.44Methotrexate
CAS:<p>Methotrexate</p>Formula:C20H22N8O5Purity:By hplc: 98.13% (Typical Value in Batch COA)Color and Shape: yellow solidMolecular weight:454.43927g/molMethotrexate Heptaglutamate Trifluoroacetate
CAS:Formula:C50H64N14O23·C2HF3O2Molecular weight:1229.14Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)
CAS:Formula:C20H22N8O5Color and Shape:Single SolutionMolecular weight:454.44Methotrexate
CAS:<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formula:C20H22N8O5Color and Shape:Yellow To Dark YellowMolecular weight:454.44Methotrexate Heptaglutamate Trifluoroacetate
CAS:Controlled ProductFormula:C50H64N14O23xC2HF3O2Color and Shape:NeatMolecular weight:1229.12
