CAS 62893-19-0

Cefoperazone

Description:

Cefoperazone is a broad-spectrum cephalosporin antibiotic, classified under the third generation of cephalosporins. It is primarily used to treat a variety of bacterial infections, particularly those caused by Gram-negative bacteria, including Pseudomonas aeruginosa. Cefoperazone is characterized by its beta-lactam structure, which is essential for its antibacterial activity. It is typically administered via injection, as it is poorly absorbed from the gastrointestinal tract. The compound is known for its stability against certain beta-lactamases, making it effective against resistant strains. Cefoperazone has a relatively long half-life, allowing for less frequent dosing compared to some other antibiotics. It is often used in combination with other antibiotics to enhance its efficacy and broaden its spectrum of activity. Common side effects may include gastrointestinal disturbances, allergic reactions, and alterations in liver function tests. As with all antibiotics, it is crucial to use cefoperazone judiciously to minimize the risk of developing antibiotic resistance.

Formula: C₂₅H₂₇N₉O₈S₂

InChI: InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1

InChI key: InChIKey=GCFBRXLSHGKWDP-XCGNWRKASA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](NC(=O)N3C(=O)C(=O)N(CC)CC3)C4=CC=C(O)C=C4)=O)C2=O)(SCC1CSC=5N(C)N=NN5)[H]

Synonyms:

• (6R,7R)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2S)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(R*)]]-
• Biocefazon
• Cefob
• Cefobid
• Cefoperazine
• Cefoperazon
• Cefoperazone,sodium salt
• Cefoperazono
• Cefozon
• Cephaperazon
• Medocef
• sodium 7-{[{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Cefoperazone

CAS: 62893-19-0, 62893-20-3

Formula: C₂₅H₂₇N₉O₈S₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 645.67

Ref: 3B-C2768

CEFOPERAZONE DIHYDRATE CRS

CAS: 62893-19-0

CEFOPERAZONE DIHYDRATE CRS

Ref: 41-C0684750

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R)-

CAS: 62893-19-0

Formula: C₂₅H₂₇N₉O₈S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 645.6674

Ref: IN-DA00IB3P

Cefoperazone

CAS: 62893-19-0

Formula: C₂₅H₂₇N₉O₈S₂

Molecular weight: 645.67

Ref: 4Z-C-7819

Cefoperazone

CAS: 62893-19-0

Formula: C₂₅H₂₇N₉O₈S₂·xH₂O

Purity: ≥ 95.0% (anhydrous basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 645.66 (anhydrous)

Ref: 7W-GA8575

Cefoperazone

CAS: 62893-19-0

Cefoperazone

Purity: ≥98%

Molecular weight: 645.67g/mol

Ref: 54-BUP18266

Cefoperazone 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 62893-19-0

Formula: C₂₅H₂₇N₉O₈S₂

Color and Shape: Single Solution

Molecular weight: 645.67

Ref: 04-A11064290AL-1000

Cefoperazone

CAS: 62893-19-0

Cefoperazone (Medocef) inactivates PBPs, disrupting bacterial cell wall synthesis and division; inhibits rMrp2 [3H]E217βG uptake (IC50: 199 μM).

Formula: C₂₅H₂₇N₉O₈S₂

Purity: 98.99% - 99.76%

Color and Shape: Solid

Molecular weight: 645.67

Ref: TM-T6437

Cefoperazone RS

CAS: 62893-19-0

Color and Shape: White To Slightly Pale Yellow Solid Crystal To Powder

Ref: 2K-7000480021

Cefoperazone Acid

Controlled Product

CAS: 62893-19-0

Applications Cefoperazone acid is an antimicrobial β-lactamase inhibitor.
References Ou, W., et al.: Zhongguo Linchuang Yaolixue Zazhi, 31, 916 (2015); Gajul, S. V., et al.: JKIMSU, 1, 1224 (2012)

Formula: C₂₅H₂₇N₉O₈S₂

Color and Shape: Neat

Molecular weight: 645.67

Ref: TR-C242903

Cefoperazone free acid

CAS: 62893-19-0

Cefoperazone free acid is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating respiratory, urinary, and skin infections.

Formula: C₂₅H₂₇N₉O₈S₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 645.67 g/mol

Ref: 3D-AC64974

Cefoperazone

CAS: 62893-19-0

Purity: 98%

Molecular weight: 645.6699829

Ref: 10-F802041

Cefoperazone N-Ethyl-d5

Controlled Product

CAS: 62893-19-0

Formula: C₂₅D₅H₂₂N₉O₈S₂

Color and Shape: Neat

Molecular weight: 650.698

Ref: TR-C242902

Cefoperazone N-Methyl-d3

Controlled Product

CAS: 62893-19-0

Formula: C₂₅D₃H₂₄N₉O₈S₂

Color and Shape: Neat

Molecular weight: 648.686

Ref: TR-C242904