CAS 66-76-2

Dicoumarol

Description:

Dicoumarol is a chemical compound that belongs to the class of anticoagulants, specifically a coumarin derivative. It is characterized by its ability to inhibit vitamin K epoxide reductase, which is crucial for the synthesis of certain clotting factors in the liver. This inhibition leads to a decrease in the levels of active vitamin K, thereby reducing blood coagulation. Dicoumarol appears as a white to pale yellow crystalline powder and is sparingly soluble in water but more soluble in organic solvents like ethanol and acetone. Its molecular formula is C18H12O5, and it has a relatively low molecular weight. The compound is primarily used in research and has historical significance as one of the first oral anticoagulants. Due to its anticoagulant properties, dicoumarol must be used with caution, as it can lead to bleeding complications if not monitored properly. Additionally, it has been studied for its potential effects on various biological processes, including its role in cancer research and as a potential therapeutic agent.

Formula: C₁₉H₁₂O₆

InChI: InChI=1/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2

InChI key: InChIKey=DOBMPNYZJYQDGZ-UHFFFAOYSA-N

SMILES: OC=1C=2C(OC(=O)C1CC3=C(O)C=4C(OC3=O)=CC=CC4)=CC=CC2

Synonyms:

• 2H-1-Benzopyran-2-one, 3,3'-methylenebis[4-hydroxy-
• 3,3'-Methylenebis[4-hydroxy-1,2-benzopyrone]
• 3,3'-Methylenebis[4-hydroxycoumarin]
• 3,3′-Methylene-bis-(4-hydroxy-2H-benzopyran-2-one)
• 3,3′-Methylenebis(4-hydroxy-2H-chromen-2-one)
• 3,3′-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one]
• Acadyl
• Acavyl
• Antitrombosin
• Baracoumin
• Bis(4-hydroxycoumarin-3-yl)methane
• Bis-3,3'-(4-hydroxycoumarinyl)methane
• Bishydroxycoumarin
• Coumarin, 3,3'-methylenebis[4-hydroxy-
• Cuma
• Cumid
• Di-4-hydroxy-3,3'-methylenedicoumarin
• Dicoumal
• Dicoumarin
• Dicoumarol
• Dicuman
• Dicumarine
• Dicumol
• Dufalone
• Kumoran
• Melitoxin
• Nc 034
• Nsc 17860
• Nsc 221570
• Nsc 41834
• Pb 2-9
• Temparin
• Trombosan
• 3,3'-Methylen-bis(4-hydroxy-cumarin)
• syringidin
• dicoumarol 4,4'-dihydroxy-3,3'-methylenebis(2H-chromen-2-one)
• 3,3’-methylenebis(4-hydroxy-2h-1-benzopyran-2-on
• 3,3’-methylene-bis(4-hydroxycoumarine)
• 3,3μ-Methylenebis(4-hydroxycoumarin), Dicumarol
• DICUMAROL
• Dicumarol,99%
• 4,4’-dihydroxy-3,3’-methylenebiscoumarin
• 3,3’-metilen-bis(4-idrossi-cumarina)
• BIS-HYDROXYCOUMARIN
• 3,3’-methylenebis(4-hydroxy-coumari
• Dikumarol
• 3,3’-methylene-bis(4-hydroxycoumarine)(french)
• nc034
• 3,3'-Methylenebis
• 3,3'-Metilen-bis(4-idrossi-cumarina)
• Dicumarol (200 mg)
• Dicoumarin (=dicoumarol)
• METHYLENEBISHYDROXYCOUMARIN
• Dicumaol R
• Di-(4-hydroxy-3-coumarinyl)methane
• 3,3'-Methylene-bis(4-hydroxycoumarine)
• 3,3’-methyleen-bis(4-hydroxy-cumarine)
• 4-HYDROXY-3-[(4-HYDROXY-2-OXO-CHROMEN-3-YL)METHYL]CHROMEN-2-ONE
• dwukumarol
• BISCUMAROL
• 3,3’-methylen-bis(4-hydroxy-cumarin)
• dicumaolr
• 3,3'-Methyleen-bis(4-hydroxy-cumarine)
• 3,3’-methylenebis[4-hydroxy-2h-1-benzopyran-2-on

Dicoumarol

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 336.30

Ref: 3B-M0216

Dicumarol

CAS: 66-76-2

Vitamin K reductase inhibitor possessing anticoagulant properties

Formula: C₁₉H₁₂O₆

Color and Shape: Powder, White to off white

Molecular weight: 336.30

Ref: 02-J63634

Dicumarol

CAS: 66-76-2

Color and Shape: Neat

Ref: 61-FOR3051.00

Dicoumarol

CAS: 66-76-2

Dicoumarol: an anticoagulant from moldy sweet-clover, depletes vitamin K, inhibits clotting enzymes.

Formula: C₁₉H₁₂O₆

Purity: 99.75% - 99.9%

Color and Shape: White Or Creamy White Crystalline Powder Solid

Molecular weight: 336.3

Ref: TM-T0809

Dicoumarol

CAS: 66-76-2

Dicoumarol

Purity: ≥98%

Molecular weight: 336.3g/mol

Ref: 54-BUP18867

3,3′-Methylene-bis(4-hydroxycoumarin)

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Molecular weight: 336.30

Ref: 7W-GL3972

Dicoumarol

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Purity: 95%~99%

Molecular weight: 336.299

Ref: BP-BP4979

Dicumarol

Controlled Product

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Color and Shape: Neat

Molecular weight: 336.30

Ref: 04-C12581000

Dicumarol

Controlled Product

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Color and Shape: Neat

Molecular weight: 336.30

Ref: 86-MM3051.00

Dicumarol-d8

Controlled Product

CAS: 66-76-2

Applications Isotope labelled Dicumarol is a natural chemical used as an anticoagulant agents that functions as a vitamin K antagonist and is also a derivative of coumarin (C755380).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sail, V., et al.: Chem. Biol. Drug. Design., 81, 334 (2013); Zsila, F., et al.: Molec. Pharma., 10, 1668 (2013); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012);

Formula: C₁₉D₈H₄O₆

Color and Shape: Light Yellow

Molecular weight: 344.34

Ref: TR-D436592

Dicoumarol

CAS: 66-76-2

Dicumarol is a coumarin derivative that inhibits the activity of polymerase chain reaction (PCR) by binding to DNA. It is also an inhibitor of nitrate reductase, which is an enzyme that catalyzes the conversion of nitrate to nitrite. Dicumarol binds to the response element on DNA and blocks the transcription of genes. This drug also has been shown to inhibit squamous cell carcinoma cells through interaction with DNA and protein thiols.

Formula: C₁₉H₁₂O₆

Purity: Min. 95%

Molecular weight: 336.30 g/mol

Ref: 3D-FD28896

4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 336.299

Ref: 10-F358134

Dicumarol

Controlled Product

CAS: 66-76-2

Applications Dicumarol is a natural chemical used as an anticoagulant agents that functions as a vitamin K antagonist and is also a derivative of Coumarin (C755380).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sail, V., et al.: Chem. Biol. Drug. Design., 81, 334 (2013); Zsila, F., et al.: Molec. Pharma., 10, 1668 (2013); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012);

Formula: C₁₉H₁₂O₆

Color and Shape: Neat

Molecular weight: 336.30

Ref: TR-D436590

3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one)

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Color and Shape: Solid

Molecular weight: 336.2950

Ref: IN-DA003PE1