CAS 87269-88-3
:Ramipril benzyl ester
Description:
Ramipril benzyl ester is a chemical compound derived from ramipril, an angiotensin-converting enzyme (ACE) inhibitor used primarily for the treatment of hypertension and heart failure. The benzyl ester modification enhances its lipophilicity, potentially affecting its pharmacokinetic properties. This compound typically appears as a white to off-white solid and is soluble in organic solvents, reflecting its ester nature. Its molecular structure includes a carboxylic acid group that has been esterified with a benzyl group, which can influence its biological activity and absorption characteristics. Ramipril itself is known for its ability to lower blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. The benzyl ester form may exhibit different pharmacological effects compared to the parent compound, making it of interest in medicinal chemistry for developing new therapeutic agents. As with many pharmaceuticals, safety and efficacy profiles are critical, and any derivatives must undergo rigorous testing to ensure they meet regulatory standards for clinical use.
Formula:C30H38N2O5
InChI:InChI=1S/C30H38N2O5/c1-3-36-29(34)25(18-17-22-11-6-4-7-12-22)31-21(2)28(33)32-26-16-10-15-24(26)19-27(32)30(35)37-20-23-13-8-5-9-14-23/h4-9,11-14,21,24-27,31H,3,10,15-20H2,1-2H3/t21-,24-,25-,26-,27-/m0/s1
InChI key:InChIKey=RENMFAJWBVYHGL-SJSXQSQASA-N
SMILES:C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2[C@@]3([C@](C[C@H]2C(OCC4=CC=CC=C4)=O)(CCC3)[H])[H]
Synonyms:- Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, phenylmethyl ester, (2S,3aS,6aS)-
- Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, phenylmethyl ester, [2S-[1[R*(R*)],2α,3aβ,6aβ]]-
- Ramipril benzyl ester
- Phenylmethyl (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylate
- 2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER
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Found 3 products.
Ramipril Benzyl Ester
CAS:<p>Ramipril is a prodrug that is hydrolyzed in vivo to ramiprilat, its active form. Ramipril benzyl ester is an active substance of the drug molecule, which belongs to the group of angiotensin-converting enzyme inhibitors. It inhibits the conversion of angiotensin I to angiotensin II, thereby reducing blood pressure and improving blood flow. Ramipril benzyl ester is a particle that has been activated by thionyl chloride, which reacts with the nitrogen atoms on the molecule's surface to produce a chloride ion and an organic solvent. The molecular modelling data was obtained using Docking software on a quantum computer.</p>Formula:C30H38N2O5Purity:Min. 95%Molecular weight:506.63 g/mol
