Inhibitor Enzymes
Inhibitor enzymes are molecules that decrease or block the activity of enzymes, preventing them from catalyzing their specific reactions. These inhibitors can be reversible or irreversible and are crucial tools in research and drug development for studying enzyme mechanisms, controlling metabolic pathways, and developing therapeutic agents. Inhibitor enzymes are widely used to modulate biological processes and to treat various diseases by targeting specific enzymes. At CymitQuimica, we offer a comprehensive range of high-quality enzyme inhibitors to support your research and pharmaceutical development needs.
Found 123 products of "Inhibitor Enzymes"
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Argatroban
CAS:Formula:C23H38N6O6SPurity:(HPLC) ≥ 98%Color and Shape:White to off-white powderMolecular weight:526.65IU1
CAS:Formula:C18H21FN2OPurity:(TLC) ≥ 98%Color and Shape:Off-white to pale brown solidMolecular weight:300.37Fumagillin
CAS:Formula:C26H34O7Purity:≥ 95.0%Color and Shape:White, off-white or pale yellow to tan powderMolecular weight:458.54Vildagliptin
CAS:Formula:C17H25N3O2Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:303.40Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS:Formula:C14H21ClN2O3S·HClPurity:(HPLC) ≥ 98.0%Color and Shape:White powderMolecular weight:369.31Nafamostat
CAS:Formula:C19H17N5O2Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:347.37Lactacystin
CAS:Formula:C15H24N2O7SPurity:≥ 95.0%Color and Shape:White solid or powderMolecular weight:376.43E-64 protease inhibitor
CAS:Formula:C15H27N5O5Purity:(HPLC) ≥ 98.0%Color and Shape:White crystalline powderMolecular weight:357.40Bestatin hydrochloride
CAS:Formula:C16H24N2O4·HClPurity:≥ 98.0% (dried basis)Color and Shape:White to almost white powderMolecular weight:344.87Bortezomib
CAS:Formula:C19H25BN4O4Purity:≥ 98.0%Color and Shape:White to off-white powder or solidMolecular weight:384.24Suramin sodium salt
CAS:Formula:C51H34N6Na6O23S6Purity:≥ 98%Color and Shape:White to off-white powderMolecular weight:1429.16Phosphoramidon disodium salt
CAS:Formula:C23H32N3Na2O10PPurity:≥ 97.0%Color and Shape:Colourless, transparent crystals or white to light yellow crystalline powderMolecular weight:587.47Nafamostat mesylate
CAS:Formula:C19H17N5O2Purity:≥ 99.0%Color and Shape:White to off-white or beige crystalline powderMolecular weight:347.37Z-Leu-Leu-Leu-al
CAS:Formula:C26H41N3O5Purity:≥ 97.0%Color and Shape:White to off-white powder or solidMolecular weight:475.63Carfilzomib
CAS:Formula:C40H57N5O7Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white crystalline powder or crystalsMolecular weight:719.91DAPT
CAS:Formula:C23H26F2N2O4Purity:(NMR) ≥ 98.0%Color and Shape:White to off-white solidMolecular weight:432.50N-p-Tosyl-L-phenylalanine chloromethyl ketone
CAS:Formula:C17H18ClNO3SPurity:(TLC) ≥ 98.0%Color and Shape:White to off-white powderMolecular weight:351.85Leupeptin hemisulfate
CAS:Formula:C20H38N6O4·5H2SO4Purity:≥ 95%Color and Shape:White to off-white powderMolecular weight:475.59Pepstatin A
CAS:Formula:C34H63N5O9Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:685.90E-64d protease inhibitor
CAS:Formula:C17H30N2O5Purity:≥ 95.0%Color and Shape:White powderMolecular weight:342.43Elastatinal microbial
CAS:Formula:C21H36N8O7Purity:~0.64μg/ml (IC50, pH8.8, 37°C)Color and Shape:White to light-yellow or tan powderMolecular weight:512.60Z-VAD-FMK, cell permeable
CAS:Formula:C22H30FN3O7Purity:≥ 95.0%Color and Shape:White to off-white solidMolecular weight:467.5AEBSF hydrochloride
CAS:Formula:C8H10FNO2S·HClPurity:≥ 98.0%Color and Shape:White to off-white powder or solidMolecular weight:239.69Apricoxib
CAS:Controlled Product<p>Applications Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.<br>References Kirane, A, et al.: Clinical Cancer Res., 18, 5031 (2012); Rohatagi, Sh., et al.: British J. Clin. Pharmaco., 66, 60 (2008);<br></p>Formula:C19H20N2O3SColor and Shape:NeatMolecular weight:356.44Vitamin B12 e-Monocarboxylic Acid
CAS:<p>Stability Hygroscopic<br>Applications Vitamin B12 Monocarboxylic Acid is an impurity of Vitamin B12 (V676005) which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.<br>References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)<br></p>Formula:C63H87CoN13O15PColor and Shape:Dark Red SolidMolecular weight:1356.35(3S,4S,3’S)-Ezetimibe
CAS:<p>Applications (3S,4S,3’S)-Ezetimbe is a 3-epimer impurity of Ezetimibe (E975000), a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C24H21F2NO3Color and Shape:Off-WhiteMolecular weight:409.43(3S,5S)-Atorvastatin Calcium Salt
CAS:Controlled Product<p>Impurity Atorvastatin Related Compound E<br>Applications Impuritiy of Atorvaststin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Atorvastatin Related Compound E<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),<br></p>Formula:C33H34FN2O5·CaColor and Shape:NeatMolecular weight:1155.34N-(2-Hydroxyethyl)-1-deoxy-L-altronojirimycin Hydrochloride Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),<br></p>Formula:C8H18ClNO5Color and Shape:NeatMolecular weight:243.68522,5-Dideoxy-2,5-imino-D-mannitol
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A glucosidase inhibitor.<br>References Fellows, L.E.: Pestic. Sci., 17, 602 (1986)<br></p>Formula:C6H13NO4Color and Shape:Off White SolidMolecular weight:163.17Nitromifene Citrate (E/Z mixture)
CAS:Controlled Product<p>Applications Nitromifene citrate is a non-steroidal estrogen antagonist. It is structurally similar to Tamoxifen (T006000) which is a selective estrogen response modifier (SERM).<br>References Rudick, C., et al.: Endorcrinol., 144, 179 (2003); Sutherland, R., et al.: Nature, 267, 434 (1977)<br></p>Formula:C33H36N2O11Color and Shape:Yellow To OrangeMolecular weight:636.65N-(2-Hydroxyethyl)-1-deoxy-L-idonojirimycin Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References van de Water, F., et al.: Drug Metab. Rev., 37, 443 (2005), Koepsell, H., et al.: Pharm. Res., 24, 1227 (2007), Jappar, D., et al.: Pharm. Res., 26, 172 (2009),<br></p>Formula:C8H18ClNO5Color and Shape:NeatMolecular weight:243.69Daidzein Diglucuronide
CAS:Controlled ProductFormula:C27H26O16Color and Shape:White To Off-WhiteMolecular weight:606.49Teneligliptin Hydrobromide (2:5)
CAS:Controlled Product<p>Applications Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. & Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>Formula:C22H32·5Br2·5N6OSColor and Shape:NeatMolecular weight:628.862-(Hydroxyamino)acetic Acid
CAS:Controlled Product<p>Applications 2-(Hydroxyamino)acetic Acid is a novel lactase inhibitor.<br>References Hattori, M., et al.: J. Insect Physiol., 51, 1359 (2005); Murao, S., et al.: Biosci. Biotech. Biochem., 56, 987 (1992)<br></p>Formula:C2H5NO3Color and Shape:NeatMolecular weight:91.07Galacto-PUGNAc (>90%)
CAS:Controlled Product<p>Stability Moisture and Temperature Sensitive<br>Applications Galacto-PUGNAc is a highly selective inhibitor for β-hexosaminidases HEXA and HEXB is cell-permeable. Galacto-PUGNAc is able to modulate the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels in neuroblastoma cells<br>References Stubbs, K.A. et al.: Angew. Chem. Int. Ed., 48, 1300 (2009);<br></p>Formula:C15H19N3O7Purity:>90%Color and Shape:NeatMolecular weight:353.33Aprotinin Hydrochloride
CAS:<p>Applications Aprotinin is used in cardiac surgery to minimize bleeding and reduce exposure to blood products.<br>References Mangano, D. et al.: New Eng. J. Med., 354, 353 (2006); Fergusson, D. et al.: New. Eng. J. Med., 358, 2319 (2008);<br></p>Formula:C284H432N84O79S7·x(ClH)Color and Shape:White SolidMolecular weight:6511.51(free amine)tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate
CAS:Controlled Product<p>Applications tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate is an orally anti-diabetic agent as a inhibitors of dipeptidylpeptidase IV (DPP-4).<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705-5719 (2012);<br></p>Formula:C27H38N6O3SColor and Shape:NeatMolecular weight:526.69LCZ696
CAS:<p>Applications LCZ696 is a novel dual-acting inhibitor of angiotensin II receptor and neprilysin, which can be used for blood pressure reduction.<br>References Ruilope, L.M.; et al.: Lancet, 375, 1255 (2010)<br></p>Formula:C24H28NO5·C24H27N5O3·3Na·x(H2O)Color and Shape:MixtureMolecular weight:479.48 + (433.47) + x(18.02)Abamine
CAS:Controlled Product<p>Applications Abamine is an inhibitor of 9-Cis-Epoxycarotenoid dioxygenase (NCED), the key regulatory enzyme in the plant hormone abscisic acid (ABA) biosynthesis pathway.<br>References Kitahata, N., et al.: Bioorg. Med. Chem., 14, 5555 (2006); Han, S., et al.: Bioorg. Med. Chem. Lett., 14, 3033 (2004)<br></p>Formula:C21H24FNO4Color and Shape:NeatMolecular weight:373.42CP-10447
CAS:<p>Applications CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.<br>References Haghpassand, M. et al.: J. Lipid. Res., 37, 1468 (1996); Pan, M. et al.: J. Biol. chem., 275, 27399 (2000);<br></p>Formula:C16H13BrN2OColor and Shape:NeatMolecular weight:329.193'-Deoxyadenosine 5’-Diphosphate Triethylamine Salt (>90%)
CAS:<p>Stability Hygroscopic<br>Applications 3'-Deoxyadenosine 5’-Diphosphate Triethylamine Salt, is a nucleotide and was proposed to be a possible inhibitor of DNA synthesis.<br>References Frederiksen, Sune.: Biochimica et Biophysica Acta, 76(3), 366-71 (1963)<br></p>Formula:C10H15N5O9P2•xC6H15NPurity:>90%Color and Shape:NeatMolecular weight:411.20 + x(101.19)Bis(2-butoxyethyl) 2-(3-Hydroxybutoxy)ethyl Phosphate Triester
CAS:Controlled Product<p>Applications Bis(2-butoxyethyl) 2-(3-Hydroxybutoxy)ethyl Phosphate Triester is derived from 2-Butoxyethanol (B692895), which is a reagent in the synthesis of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Also used as a reagent in the synthesis of 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.<br>References Sun, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3798 (2011); Yi, W., et al.: Eur. J. Med. Chem., 45, 639 (2010)<br></p>Formula:C18H39O8PColor and Shape:Colourless To Light YellowMolecular weight:414.47Nicotelline
CAS:Controlled Product<p>Applications Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);<br></p>Formula:C15H11N3Color and Shape:NeatMolecular weight:233.27Naringenin chalcone
CAS:Controlled ProductFormula:C15H12O5Color and Shape:NeatMolecular weight:272.25N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
CAS:Controlled Product<p>Applications Naphthalenesulfonamides derivatives are neoplasm inhibitors.<br>References Hidaka, H., et al.: Proc. Nat. Acad. Sci. USA, 78, 4354 (1981)<br></p>Formula:C20H29ClN2O2S·ClHColor and Shape:NeatMolecular weight:433.44Avelestat
CAS:Controlled Product<p>Applications Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.<br>References Stevens, T., et al.: J. Pharmacol. Exp. Ther., 339, 313 (2011)<br></p>Formula:C25H22F3N5O4SColor and Shape:NeatMolecular weight:545.53Enviroxime
CAS:Controlled Product<p>Applications Enviroxime is a benzimidazole derivative that inhibits rhinovirus multiplication.<br>References De Long, D.C., et al.: J. Infect. Dis., 141, 87 (1980), Wikel, J.H., et al.: J. Med. Chem., 23, 368 (1980), Phillpotts, R.J., et al.: Lancet, 1, 1342 (1981), Haden, F.G., et al.: Antimicrob. Agents Chemother., 21, 892 (1982),<br></p>Formula:C17H18N4O3SColor and Shape:NeatMolecular weight:358.41Benzyl Methyl Carbonate
CAS:Controlled Product<p>Applications Benzyl Methyl Carbonate is used in designing of inhibitors for serine and thiol proteases.<br></p>Formula:C9H10O3Color and Shape:NeatMolecular weight:166.174,5,6,7-Tetrabromo-1H-benzotriazole
CAS:Controlled Product<p>Applications TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.<br>References Boehning, D., et al.: Neuron, 40, 129 (2993)<br></p>Formula:C6HBr4N3Color and Shape:NeatMolecular weight:434.71Chelerythrine Chloride
CAS:<p>Stability Hygroscopic<br>Applications Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.<br>References Song, L., et. al.: Brain Res., 1564, 52 (2014)<br></p>Formula:C21H18NO4·ClColor and Shape:YellowMolecular weight:383.82(R)-Pinocembrin
CAS:Controlled Product<p>Applications (2R)-Pinocembrin is the (R)-enantiomer of Pinocembrin, a flavanoid with antioxidant activity found in damiana, honey, and propolis. (2R)-Pinocembrin is a potential inhibitor of PIM1 kinase, an oncogene that has been implicated in the development of leukemias, lymphomas, and prostate cancer.<br>References Zhao, J. et al.: J. Ethnopharmacol., 120, 387 (2008); Holder, S. et al.: Mol. Cancer Ther., 6, 163 (2007); Holder, S. et al.: Bioorg. Med. Chem., 15, 6463 (2007);<br></p>Formula:C15H12O4Color and Shape:WhiteMolecular weight:256.25O,O-Dimethyl Dithiophosphate
CAS:Controlled ProductFormula:C2H7O2PS2Color and Shape:ColourlessMolecular weight:158.18Morusin
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Morusin is an inhibitor of human cervical cancer stem cell growth, attenuating NF-kB activity, and initiating apoptosis.<br>References Wang, L. et al.: Mol. Cell. Biochem., 379, 7 (2013);<br></p>Formula:C25H24O6Color and Shape:NeatMolecular weight:420.45GDC 0152
CAS:Controlled Product<p>Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.<br>References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)<br></p>Formula:C25H34N6O3SColor and Shape:NeatMolecular weight:498.64Ipidacrine Hydrochloride Hydrate
CAS:Formula:C12H16N2·ClH·H2OColor and Shape:NeatMolecular weight:242.753a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-methyl-(3aR,5R,6S,7R,7aR)-5H-pyrano[3,2-d]thiazole-6,7-diol
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-methyl-(3aR,5R,6S,7R,7aR)-5H-pyrano[3,2-d]thiazole-6,7-diol, can be used in the synthesis of Hexosaminidase inhibitors, which are the new drug candidates for the therapy of osteoarthritis.<br>References Liu, J. et al.: Chem. Bio., 8, 701 (2001);<br></p>Formula:C8H13NO4SColor and Shape:White To Light BeigeMolecular weight:219.26Bisindolylmaleimide VIII Acetic Acid Salt
CAS:Controlled Product<p>Applications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.<br>References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),<br></p>Formula:C26H26N4O4Color and Shape:NeatMolecular weight:458.511-(5-Isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride
CAS:Controlled Product<p>Applications A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases.<br>References Hidaka, H. and Kawamoto, S.: Biochem. and Biophys. Res. Comm., 125, 1, 258 (1984)<br></p>Formula:C14H17N3O2S·2ClHColor and Shape:NeatMolecular weight:364.29O,S-Diethyl Methylphosphonothioate
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications An inhibitor of cholinesterase.<br>References Berman, H., et al.: J. Biol. Chem., 264, 3951 (1989), Millard, C., et al.: Biochemistry, 37, 237 (1998), Koellner, G., et al.: J. Mol. Biol., 296, 713 (2000),<br></p>Formula:C5H13O2PSColor and Shape:NeatMolecular weight:168.193-Acetyl-11-keto-β-boswellic Acid
CAS:Controlled ProductFormula:C32H48O5Color and Shape:WhiteMolecular weight:512.721-Propan-1,1,2,2,3,3,3-d7-amine
CAS:Controlled ProductFormula:C3H2D7NColor and Shape:NeatMolecular weight:66.15O-(2,4-Dinitrophenyl)hydroxylamine
CAS:<p>Applications O-(2,4-Dinitrophenyl)hydroxylamine is a rapid active-site-directed inhibitor of D-amino acid oxidase; modification results in specific incorporation of an amine group into an accessible nucleophilic residue with concomitant release of 2,4-dinitrophenol.<br>References D'Silva, C., et al.: Biochemi., 25, 5602 (1986),<br></p>Formula:C6H5N3O5Color and Shape:Brown SolidMolecular weight:199.12N-Acetyl-Lys-Octreotide Trifluoroacetic Acid Salt
CAS:<p>Stability Hygroscopic<br>Applications N-Acetyl-Phe-Octreotide is used as reactant/reagent in inhibition of octreotide acylation inside PLGA microspheres by derivatization of amines of peptide with self-immolative protecting group.<br>References Shirangi, M., et al.: Bioconjugate Chem., 27, 576-585 (2016)<br></p>Formula:C51H68N10O11S2·xC2HF3O2Color and Shape:NeatMolecular weight:1061.284Resolvin E1 Sodium Salt
CAS:Controlled ProductFormula:C20H29NaO5Color and Shape:NeatMolecular weight:372.431(5E)-6-(4-Hydroxy-3-methoxyphenyl)-5-hexene-2,4-dione
CAS:Controlled Product<p>Applications Curcumin (C838500) and gingerdione derivative. A possible human glyoxalase I inhibitor. Flavor modifier.<br>References Yuan, M. et al.; Bioorg. Med. Chem. 19, 1189 (2011); Ley, J. et al.; J. Agr. Food Chem. 56, 6656 (2008)<br></p>Formula:C13H14O4Color and Shape:NeatMolecular weight:234.25(±)-Procinolol Hydrochloride
CAS:Controlled Product<p>Applications (±)-Procinolol is a beta adrenergic receptor antagonist.<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>Formula:C15H24ClNO2Color and Shape:NeatMolecular weight:285.81Baohuoside I
CAS:Controlled Product<p>Applications Baohuoside I is an inhibitor of cell growth and also is a down-regulator of durvivin and cyclin D1 expression. Used in the treatment of esophageal cancer. Anti-cancer agent.<br>References Lifang, W. et al.: Oncology Rep., 26, 1149 (2011); Jin, X. et al.: Drug Dev. Ind. Pharm., 39, 1421 (2013);<br></p>Formula:C27H30O10Color and Shape:NeatMolecular weight:514.52Raloxifene 4’-β-D-Glucuronide Lithium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Raloxifene 4’-Glucuronide Lithium Salt is a metabolite of Raloxifene (R099995), a nonsteroidal estrogen receptor mixed agonist/antagonist.<br>References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997); Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005); Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005); Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006)<br></p>Formula:C34H34LiNO10SColor and Shape:NeatMolecular weight:655.644-Amino-5-(bromomethyl)-2-methylpyrimidine Dihydrobromide
CAS:Controlled Product<p>Applications A pyrimidine derivative as G protein-coupled receptor kinase (GRK) inhibitor.<br>References Bigham, E., et al.: J. Med. Chem., 35, 1399 (1992), Jansen, M., et al.: Biochem. Pharmacol., 47, 1067 (1994), Hasbi, A., et al.: J. Neurochem., 70, 2129 (1998),<br></p>Formula:C17H17N3O2SColor and Shape:NeatMolecular weight:327.40N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
CAS:Controlled Product<p>Applications Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hidaka, H., et al.: J. of Biol. Chem., 264, 9, 4924 (1989)<br></p>Formula:C11H12ClN3O2S·2ClHColor and Shape:NeatMolecular weight:358.67Retorphan
CAS:Controlled Product<p>Applications Retorphan is a powerful and selective inhibitors of neprilysin and is being developed as a therapeutic agent. Retorphan behave as the prodrug of the enantiomers of Thiorphan (T369500).<br>References Monteil, T., et al.: Mini. Rev. Med. Chem., 2, 209 (2002); Roques, B.P., et al.: Nature, 288, 286 (1980); Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)<br></p>Formula:C21H23NO4SColor and Shape:NeatMolecular weight:385.48(1R,2R)-2-Fluorocyclopentanamine Hydrochloride
CAS:Controlled Product<p>Applications A cyclopentanamine used in the preparation of heterocyclic and aromatic ureas and amides as CEPT inhibitors.<br></p>Formula:C5H11ClFNColor and Shape:NeatMolecular weight:139.61-Deoxy-L-altronojirimycin Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),<br></p>Formula:C6H13NO4·ClHPurity:>90%Color and Shape:NeatMolecular weight:199.634-Fluorobenzoic Acid-d4
CAS:Controlled Product<p>Applications 4-Fluorobenzoic Acid-d4 is used as a reagent in the synthesis of Flurofamide-d4 (F596687); the isotope labelled analog of Fluorofamide (F596685) which is a compound that acts as a urease inhibitor, useful in the treatment of gastritis and irregular urease activity in the urinary tract.<br>References Loes, A. et al.: Lett. App. Microbiol., 58, 31 (2014); Ohta, T.et al.: Biochem. Biophys, Res. Comm., 285, 728 (2001)<br></p>Formula:C7HD4FO2Color and Shape:NeatMolecular weight:144.14tert-Butyl (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate
CAS:Controlled ProductFormula:C17H30BNO4Color and Shape:NeatMolecular weight:323.24n-Pentyl-d11 chloroformate
CAS:Controlled Product<p>Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.<br>References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.<br></p>Formula:C6D11ClO2Color and Shape:NeatMolecular weight:161.674-Pyridin-2,3,5,6-d4-ol-d
CAS:Controlled Product<p>Applications 4-Pyridin-2,3,5,6-d4-ol-d is one of the azepanone derivatives studies as CGRP receptor antagonists.<br>References Liu, J.: PCT Int. Appl. (2010), WO 2010108103 A1 20100923.<br></p>Formula:C5D5NOColor and Shape:NeatMolecular weight:100.13n-Propyl-2,2,3,3,3-d5-amine Hydrochloride
CAS:Controlled Product<p>Applications n-Propyl-2,2,3,3,3-d5-amine Hydrochloride is the hydrochloride salt of 1-Propyl-d5-amine (P833702); the isotope labelled analog of 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br>References Goto, T. et al.: Bioorg. Med. Chem., 21, 7025 (2013); Lee, C. et al.: Bioorg. Med. Chem. 21, 7125, (2013)<br></p>Formula:C3H5D5ClNColor and Shape:NeatMolecular weight:100.6tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate
CAS:Controlled ProductFormula:C18H17BrN2O3Color and Shape:NeatMolecular weight:389.24GW4869 TFA Salt (~90%, ~10% inorganics)
CAS:Controlled Product<p>Applications GW4869 is a selective inhibitor of N-SMase.<br>References Lallemand, T., et al.: Arterioscler. Thromb. Vasc. Biol., 38, 1479 (2018); Figuera-Losada, M., et al.: PLoS One, 10, 0124481 (2015)<br></p>Formula:C30H28N6O2·xC2HF3O2Color and Shape:NeatMolecular weight:504.58 + x(114.02)N-Fmoc-glycine-d2
CAS:Controlled Product<p>Applications Isotope labelled N-Fmoc-glycine is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.<br>References Eulenberg, V., et al.: Trend. Biochem. Sci., 30, 325 (2005); Gundersen, R., et al.: Acta Anaesth. Scand., 49, 1108 (2005); Lockart, R. & Eagle, H.: Science, 129, 252 (1959); Sogabe, K., et al.: Kidn. Int., 50, 845 (1996)<br></p>Formula:C17H13D2NO4Color and Shape:NeatMolecular weight:299.32Ethyl Palmitate-d31
CAS:Controlled Product<p>Applications A labelled fatty acid found in Amaranth oil; it shows inhibitory activity.<br>References Fidler, N., et al.: J. Lipid Res., 41, 1376 (2000), Yang, T., et al.: Food Chem., 80, 473 (2003), Gamel, T., et al.: J. Food Lipids, 14, 323 (2007),<br></p>Formula:C18H5D31O2Color and Shape:NeatMolecular weight:315.671-Propyl-d5-amine
CAS:Controlled Product<p>Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C3H4D5NColor and Shape:NeatMolecular weight:64.14(3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications (3R,5S,6E)-7-(2-cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt is an impurity of Pitavastatin (P531000), a HMG CoA reductase inhibitor and an antilipemic agent.<br>References Suzukim M., et al.: Bioorg. Med. Chem., 9, 2977 (1999); Yen, H., et al.: J. Clin. Invest., 98, 1253 (1996); Zou, Y., et al.: J. Biol. Chem., 274, 9760 (1999); Sun, X., et al.: Cancer Res., et al.: 61, 3382 (2001); Ladas, E.J., et al.: Clin. Oncol., 22, 517 (2004);<br></p>Formula:C25H24NNaO4Color and Shape:NeatMolecular weight:425.45rac-1,2-Dioctanoyl-3-Chloropropanediol
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications rac-1,2-Dioctanoyl-3-Chloropropanediol was studied for its ability to act as an inhibitor of protein kinase C.<br>References Briggs, Josie C., et al.: Carbohydrate Res., 234, 23-35 (1992)<br></p>Formula:C19H35ClO4Color and Shape:NeatMolecular weight:362.93N-(n-Butyl)phosphoric Triamide
CAS:<p>Applications N-Alkyl phosphoric triamide useful as urease inhibitors.<br></p>Formula:C4H14N3OPColor and Shape:White SolidMolecular weight:151.153-Amino-N-(Tertbutylbenzenesulfonamide
CAS:Controlled Product<p>Applications 3-Amino-N-(Tert-Butyl)Benzenesulfonamide (cas# 608523-94-0) is a useful research chemical.<br></p>Formula:C10H16N2O2SColor and Shape:NeatMolecular weight:228.31(E)-a-Hydroxy Tamoxifen
CAS:Controlled Product<p>Applications A metabolite of the chemotherapeutic drug Tamoxifen (T006000). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.<br>References Kupfer, D., et al.: Cancer Res., 54, 3140 (1994), Custodio, J.B.A., et al.: Biochem. Pharmacol., 47, 1989 (1994),<br></p>Formula:C26H29NO2Color and Shape:NeatMolecular weight:387.51Valtrate
CAS:Controlled Product<p>Applications Valtrate is a Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.<br>References Murakami, N., et al.: Bioorg. Med. Chem. Lett., 12, 2807 (2002); Watanabe, K., et al.: Drug Discoveries Ther., 5, 26 92011)<br></p>Formula:C22H30O8Color and Shape:Light Brown To Dark YellowMolecular weight:422.47A 83-01
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability.<br>References Minowa, T. et al.: British. J. Canc., 101, 1884 (2009)<br></p>Formula:C25H19N5SColor and Shape:Off-WhiteMolecular weight:421.52(3R)-1-Methyl-3-Pyrrolidinemethanol
CAS:Controlled Product<p>Applications (3R)-1-Methyl-3-Pyrrolidinemethanol is a reactant in the synthesis of heterocyclic carboxylic acid amides with potential as PDK1 inhibitors.<br></p>Formula:C6H13NOColor and Shape:NeatMolecular weight:115.17N-Des-2-methylpropan-2-ol Docetaxel
Controlled ProductFormula:C39H45NO13Color and Shape:NeatMolecular weight:735.77356α-Methylandrost-4-ene-3,17-dione
CAS:Controlled ProductFormula:C20H28O2Color and Shape:NeatMolecular weight:300.44B-[2-(Methylamino)-4-pyridinyl]boronic Acid Hydrochlroide Hydrate
CAS:Controlled Product<p>Applications B-[2-(Methylamino)-4-pyridinyl]boronic Acid Hydrochlroide, is used to prepare novel selective thiazoleacetic acids as CRTH2 antagonists.<br>References Grimstrup, M., et al.: Bioorg. Med. Chem. Lett., 20, 1181 (2010)<br></p>Formula:C6H9BN2O2•HCl•xH2OColor and Shape:NeatMolecular weight:151.963646N-(4'-Cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl] Urea
CAS:Controlled Product<p>Applications N-(4'-Cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl] Urea, is a highly selective inhibitor of cytochrome P450 3A4, which is one of the most important enzymes involved in the metabolism of pharmaceuticals and xenobiotics.<br>References Song, X., et al.: Bio. Med. Chem. Lett., 22, 1611(2012);<br></p>Formula:C26H18N6OColor and Shape:NeatMolecular weight:430.464-Hydroxypiperidine-D4
CAS:Controlled Product<p>Applications 4-Hydroxypiperidine-D4 is an isotope labelled form of 4-Hydroxypiperidine (H950845), a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999);<br></p>Formula:C5H7D4NOColor and Shape:NeatMolecular weight:105.17Ethyl 2-[[(3aR,4S,6R,6aS)-6-[(Benzyloxycarbonyl)amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]acetate
CAS:Controlled ProductFormula:C20H27NO7Color and Shape:NeatMolecular weight:393.43(-)-Epigallocatechin Gallate-d3/d4
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Labelled (-)-Epigallocatechin Gallate, a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-ß and amaloid plaques in mice.<br>References Yamane, T. et al.: Cancer Res., 55, 2081 (1995); Tan, J. et al.: J. Neurosci. 25, 8807 (2005);<br></p>Formula:C22D3H15O11Color and Shape:NeatMolecular weight:461.39(-)-Huperzine A-d6 (Major)
CAS:Controlled ProductFormula:C15H11D7N2OColor and Shape:NeatMolecular weight:248.35K252a
CAS:Controlled Product<p>Applications K252a is a protein kinase inhibitor. It is an analogue of staurosporine (S685000). It shows potent antitumor activity but no antimicrobial activity in vitro, or in vivo toxicity in rodents.<br>References Kase, H., et al.: J. Antibiot., 39, 1059 (1986); Yasuzawa, T., et al.; J. Antibiot., 39, 1072 (1986)<br></p>Formula:C27H21N3O5Color and Shape:NeatMolecular weight:467.47N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin
CAS:Controlled ProductFormula:C14H26F3NO5Color and Shape:NeatMolecular weight:345.362-Methylbutyryl-d9 Chloride
CAS:Controlled ProductFormula:C5D9ClOColor and Shape:NeatMolecular weight:129.63N-Butyldeoxymannojirimycin Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An extremely potent and selective a-D-mannosidase inhibitor.<br></p>Formula:C10H21NO4·ClHColor and Shape:NeatMolecular weight:255.74D,L-Alanosine Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications D,L-Alanosine is an antibiotic substance from the fermentation of Streptomyces alanosinicus. An experimental insect reproduction inhibitor.<br>References Gale, et al.: Biochem. Pharmacol., 17, 363 (1968); Kenaga, E.E.: J. Econ. Entomol., 62, 1006 (1969); Matsumoto, S., et al.: Agric. Biol. Chem., 48, 827 (1984)<br></p>Formula:C3H6N3NaO4Color and Shape:NeatMolecular weight:171.09rac-syn-Ezetimibe
Controlled Product<p>Applications rac-syn-Ezetimibe is an analog of Ezetimibe (E975000); an antihyperlipoproteinemic and a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C24H21F2NO3Color and Shape:NeatMolecular weight:409.434”DeFluoro-4”methyl-Ezetimibe
CAS:Controlled ProductFormula:C25H24FNO3Color and Shape:NeatMolecular weight:405.46Homoveratrylamine-d10 Hydrochloride
CAS:Controlled Product<p>Applications Labelled 2-(3,4-Dimethoxyphenyl)-N-methylethylamine (D470710, free amine) which is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies.<br>References Gluck, M.R. et al.: J. Neurochem., 91, 788 (2004); Charlton, C.G. et al.: Life Sci., 66, 2159 (2000);<br></p>Formula:C10H6D10ClNO2Color and Shape:NeatMolecular weight:227.752,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid
CAS:Controlled Product<p>Applications This compound is used in the synthesis of novel lactate dehydrogenase A inhibitors.This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Ward, R.A. et al.: J. Med. Chem., 55, 3258 (2012);<br></p>Formula:C22H22O4Color and Shape:NeatMolecular weight:350.41Edrophonium-d5 Chloride
CAS:Controlled ProductFormula:C10D5H11NO·ClColor and Shape:NeatMolecular weight:206.72Diethyl-d10 Carbonate
CAS:Controlled Product<p>Applications Diethyl-d10 Carbonate is deuterium labelled Diethyl Carbonate (D444000), which is used in the synthesis of 2-oxooxazolidines as antibacterials. It can also be used to synthesize donepezil/huperzine fragments as acetylcholinesterase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gregory, W. et al.: J. Med. Chem., 32, 1673 (1989); Bioorg. Med. Chem., 21, 676 (2013)<br></p>Formula:C5D10O3Color and Shape:NeatMolecular weight:128.19Methanesulfonyl Chloride-d3,13C
CAS:Formula:C2H3ClO2SColor and Shape:Colourless OilMolecular weight:118.56
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