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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • CDK7-IN-31
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    CDK7-IN-31

    CAS:
    <p>CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.</p>
    Formula:C27H32F5N6O2P
    Color and Shape:Solid
    Molecular weight:598.55

    Ref: TM-T201665

  • Protein kinase inhibitor 11
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    Protein kinase inhibitor 11

    CAS:
    <p>Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.</p>
    Formula:C21H18FN5O2S
    Color and Shape:Solid
    Molecular weight:423.463

    Ref: TM-T205016

  • Cdc7-IN-8
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    Cdc7-IN-8

    CAS:
    <p>Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)</p>
    Formula:C19H21N5O2
    Color and Shape:Solid
    Molecular weight:351.40

    Ref: TM-T61224

  • CDK6-IN-1
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    CDK6-IN-1

    CAS:
    <p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>
    Formula:C30H23N5
    Color and Shape:Solid
    Molecular weight:453.54

    Ref: TM-T201591

  • CymitQuimica logo
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    Anticancer agent 30

    <p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>
    Formula:C22H15ClFNO
    Color and Shape:Solid
    Molecular weight:363.81

    Ref: TM-T61379

  • Protein Kinase Inhibitor 12
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    Protein Kinase Inhibitor 12

    CAS:
    <p>Protein Kinase Inhibitor 12 (compound 1-91) is protein kinase inhibitor,PIM-1, CDK-2, GSK-3, and SRC mammalian protein kinases.</p>
    Formula:C14H14N4OS
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:286.35

    Ref: TM-T204404

  • YKL-1-116
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    YKL-1-116

    CAS:
    <p>YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.</p>
    Formula:C34H38N8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:606.72

    Ref: TM-T24643

  • CDK9/PARP-IN-1
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    CDK9/PARP-IN-1

    CAS:
    <p>CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.</p>
    Formula:C38H34F2N8O3
    Color and Shape:Solid
    Molecular weight:688.725

    Ref: TM-T205731

  • Protein kinase inhibitor 13
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    Protein kinase inhibitor 13

    CAS:
    <p>Protein kinase inhibitor 13 (Compound I-90) functions as a kinase inhibitor, specifically targeting kinases such as PIM-1, CDK-2, GSK-3, and SRC.</p>
    Formula:C19H20FN5OS
    Color and Shape:Solid
    Molecular weight:385.458

    Ref: TM-T205679

  • Cdc7-IN-19
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    Cdc7-IN-19

    CAS:
    <p>Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].</p>
    Formula:C19H21N5O2
    Color and Shape:Solid
    Molecular weight:351.40

    Ref: TM-T61223

  • CDK8-IN-5
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    CDK8-IN-5

    CAS:
    <p>CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.</p>
    Formula:C26H22N2O4
    Color and Shape:Solid
    Molecular weight:426.46

    Ref: TM-T62310

  • CDK4/6-IN-3
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    CDK4/6-IN-3

    CAS:
    <p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: &lt;0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>
    Formula:C25H31FN8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.57

    Ref: TM-T10737

  • SGC-CLK-1
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    SGC-CLK-1

    CAS:
    <p>SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.</p>
    Formula:C19H15F3N6O2
    Color and Shape:Solid
    Molecular weight:416.36

    Ref: TM-T201181

  • p38α inhibitor 9
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    p38α inhibitor 9

    CAS:
    <p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>
    Formula:C27H24FN3O3
    Color and Shape:Solid
    Molecular weight:457.496

    Ref: TM-T206722

  • GFB-12811
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    GFB-12811

    CAS:
    <p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>
    Formula:C22H23F4N5O
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:449.44

    Ref: TM-T62695

  • LY3143921 hydrate
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    LY3143921 hydrate

    CAS:
    <p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>
    Formula:C16H14FN5O2
    Purity:98.43%
    Color and Shape:Solid
    Molecular weight:327.31

    Ref: TM-T9064

  • Tanuxiciclib
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    Tanuxiciclib

    CAS:
    <p>Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.</p>
    Formula:C15H13FN6O
    Color and Shape:Solid
    Molecular weight:312.308

    Ref: TM-T39404

    ne
    Discontinued
    Discontinued product
  • GSK-3/CDK5/CDK2-IN-1
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    GSK-3/CDK5/CDK2-IN-1

    CAS:
    <p>GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].</p>
    Formula:C21H22N4O2
    Color and Shape:Solid
    Molecular weight:362.433

    Ref: TM-T35555

    ne
    Discontinued
    Discontinued product
  • Tibremciclib
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    Tibremciclib

    CAS:
    <p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>
    Formula:C28H32F2N8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:518.6

    Ref: TM-T79863

    ne
    Discontinued
    5mg
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    50mg
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    Discontinued product
  • YK-2168
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    YK-2168

    CAS:
    <p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>
    Formula:C16H18ClN5
    Color and Shape:Solid
    Molecular weight:315.80

    Ref: TM-T200769

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    Discontinued product