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DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 957 products of "DNA Damage/DNA Repair"

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  • Namitecan
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    Namitecan

    CAS:
    <p>Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.</p>
    Formula:C23H22N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:434.44

    Ref: TM-T16268

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    ATM Inhibitor-3

    <p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>
    Formula:C25H29FN6O3
    Color and Shape:Solid
    Molecular weight:480.53

    Ref: TM-T63171

  • Gimatecan
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    Gimatecan

    CAS:
    <p>Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>
    Formula:C25H25N3O5
    Purity:98.47%
    Color and Shape:Solid
    Molecular weight:447.48

    Ref: TM-T21319

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    DNA-PK-IN-9

    <p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>
    Formula:C21H21N5O2
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T61533

  • Intoplicine
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    Intoplicine

    CAS:
    <p>Intoplicine is an inhibitor of DNA topoisomerase I and II.</p>
    Formula:C21H24N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:348.44

    Ref: TM-T15586

  • 2-Ethylhexyl diphenyl phosphate
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    2-Ethylhexyl diphenyl phosphate

    CAS:
    <p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>
    Formula:C20H27O4P
    Color and Shape:Solid
    Molecular weight:362.40

    Ref: TM-T204320

  • DLK-IN-1
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    DLK-IN-1

    CAS:
    <p>DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.</p>
    Formula:C20H24F3N5O2
    Color and Shape:Solid
    Molecular weight:423.43

    Ref: TM-T11056

  • L2H2-6OTD
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    L2H2-6OTD

    CAS:
    <p>L2H2-6OTD is a telomerase inhibitor with G-quadruplex loops; IC50: 15 nM.</p>
    Formula:C30H30N10O8
    Color and Shape:Solid
    Molecular weight:658.62

    Ref: TM-T73264

  • SP-C01
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    SP-C01

    CAS:
    <p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>
    Formula:C22H22F4N2O5
    Color and Shape:Solid
    Molecular weight:470.41

    Ref: TM-T207419

  • DNA crosslinker 4 dihydrochloride
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    DNA crosslinker 4 dihydrochloride

    CAS:
    <p>DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.</p>
    Formula:C16H24Cl2N8O
    Color and Shape:Solid
    Molecular weight:415.32

    Ref: TM-T74340

  • 15-keto-Prostaglandin E2
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    15-keto-Prostaglandin E2

    CAS:
    <p>15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression.</p>
    Formula:C20H30O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:350.45

    Ref: TM-T78582

  • TDI-015051
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    TDI-015051

    CAS:
    <p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>
    Formula:C22H22FN5O4S
    Color and Shape:Solid
    Molecular weight:471.505

    Ref: TM-T204648

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    Cas9-IN-1

    <p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>
    Formula:C17H11Cl2F3N2O3S
    Color and Shape:Solid
    Molecular weight:451.25

    Ref: TM-T62736

  • HDAC6-IN-51
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    HDAC6-IN-51

    CAS:
    <p>HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.</p>
    Formula:C24H24ClN5O3
    Color and Shape:Solid
    Molecular weight:465.93

    Ref: TM-T201184

  • DNA-PK-IN-15
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    DNA-PK-IN-15

    CAS:
    <p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>
    Formula:C23H23N9O
    Color and Shape:Solid
    Molecular weight:441.49

    Ref: TM-T201160

  • DNA-PK-IN-2
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    DNA-PK-IN-2

    CAS:
    <p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>
    Formula:C20H23N5O3
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T61633

  • DNA crosslinker 3 dihydrochloride
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    DNA crosslinker 3 dihydrochloride

    CAS:
    <p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>
    Formula:C15H22Cl2N8O
    Color and Shape:Solid
    Molecular weight:401.29

    Ref: TM-T74339

  • TH1338
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    TH1338

    CAS:
    <p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>
    Formula:C22H21N3O4
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T28959

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    SARS-CoV-2 nsp14-IN-1

    <p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>
    Formula:C20H20N6O5S
    Color and Shape:Solid
    Molecular weight:456.48

    Ref: TM-T62829

  • TERT activator-2
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    TERT activator-2

    CAS:
    <p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>
    Formula:C21H22N2O2
    Color and Shape:Solid
    Molecular weight:334.412

    Ref: TM-T205533