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Endocrinology/Hormones

Endocrinology/Hormones

Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.

Subcategories of "Endocrinology/Hormones"

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Found 3178 products of "Endocrinology/Hormones"

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  • AR antagonist 10
    Targetmol
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    AR antagonist 10

    CAS:
    <p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>
    Formula:C18H17ClN4O3S
    Color and Shape:Solid
    Molecular weight:404.871

    Ref: TM-T205420

  • KNT-127
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    KNT-127

    CAS:
    <p>KNT-127 is an agonist of δ-Opioid receptor.</p>
    Formula:C24H24N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T25583

  • EN1441
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    EN1441

    CAS:
    <p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>
    Formula:C13H13ClN2O2
    Color and Shape:Solid
    Molecular weight:264.708

    Ref: TM-T206982

  • AP5
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    AP5

    CAS:
    <p>AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.</p>
    Formula:C28H28FNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.52

    Ref: TM-T13550

  • Glucocorticoid receptor activator 1
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    Glucocorticoid receptor activator 1

    CAS:
    <p>Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.</p>
    Formula:C11H15Cl2NO2
    Color and Shape:Solid
    Molecular weight:264.15

    Ref: TM-T201578

  • Androgen receptor antagonist 12
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    Androgen receptor antagonist 12

    CAS:
    <p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>
    Formula:C12H8F3N3O2
    Color and Shape:Solid
    Molecular weight:283.21

    Ref: TM-T201604

  • Naltrindole 5′-isothiocyanate
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    Naltrindole 5′-isothiocyanate

    CAS:
    <p>Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.</p>
    Formula:C27H25N3O3S
    Color and Shape:Solid
    Molecular weight:471.571

    Ref: TM-T205509

  • LEO 134310
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    LEO 134310

    CAS:
    <p>LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.</p>
    Formula:C34H40N2O8
    Color and Shape:Solid
    Molecular weight:604.69

    Ref: TM-T69930

  • 6:2 Cl-PFAES
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    6:2 Cl-PFAES

    CAS:
    <p>6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.</p>
    Formula:C8ClF16KO4S
    Color and Shape:Solid
    Molecular weight:570.67

    Ref: TM-T201602

  • Urotensin-II receptor antagonist-1
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    Urotensin-II receptor antagonist-1

    CAS:
    <p>Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).</p>
    Formula:C25H31Cl2N3O
    Color and Shape:Solid
    Molecular weight:460.439

    Ref: TM-T205347

  • SJ1008066
    Targetmol
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    SJ1008066

    CAS:
    <p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>
    Formula:C21H22N4
    Color and Shape:Solid
    Molecular weight:330.43

    Ref: TM-T201713

  • Glucocorticoid receptor agonist-5
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    Glucocorticoid receptor agonist-5

    CAS:
    <p>Glucocorticoid Receptoragonist-5 (compound 4) is an effective glucocorticoid molecule acting as a potent agonist for glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive activities and serves as an ADC cytotoxin.</p>
    Formula:C36H40O7
    Color and Shape:Solid
    Molecular weight:584.7

    Ref: TM-T201729

  • 22-Hydroxy mifepristone
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    22-Hydroxy mifepristone

    CAS:
    <p>22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.</p>
    Formula:C29H35NO3
    Color and Shape:Solid
    Molecular weight:445.59

    Ref: TM-T201780

  • Galaxolide
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    Galaxolide

    CAS:
    <p>Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).</p>
    Formula:C18H26O
    Color and Shape:Solid
    Molecular weight:258.40

    Ref: TM-T201465

  • Erα-IN-1
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    Erα-IN-1

    <p>Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.</p>
    Formula:C16H11FN2
    Color and Shape:Solid
    Molecular weight:250.27

    Ref: TM-T201461

  • Estrogen receptor antagonist 7
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    Estrogen receptor antagonist 7

    CAS:
    <p>ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.</p>
    Formula:C23H17N3O4
    Color and Shape:Solid
    Molecular weight:399.4

    Ref: TM-T61909

  • Amoitone B
    Targetmol
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    Amoitone B

    CAS:
    <p>Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].</p>
    Formula:C22H34O5
    Color and Shape:Solid
    Molecular weight:378.5

    Ref: TM-T85646

  • JDTic Dihydrochloride
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    JDTic Dihydrochloride

    CAS:
    <p>JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.</p>
    Formula:C28H41Cl2N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.55

    Ref: TM-T11721L

  • AR antagonist 11
    Targetmol
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    AR antagonist 11

    CAS:
    <p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>
    Formula:C20H17ClN2O
    Color and Shape:Solid
    Molecular weight:336.815

    Ref: TM-T206875

  • ERβ agonist-1
    Targetmol
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    ERβ agonist-1

    CAS:
    <p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>
    Formula:C25H36O2
    Color and Shape:Solid
    Molecular weight:368.55

    Ref: TM-T207458