Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(136 products)
- CXCR(147 products)
- Cell wall(5 products)
- IL Receptor(113 products)
- IκB/IKK(61 products)
- LTR(3 products)
- MALT(23 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(445 products)
- NOD(17 products)
- NOS(63 products)
- Nrf2(78 products)
- PGE Synthase(31 products)
- ROS(69 products)
- TGF-beta/Smad(58 products)
- TLR(66 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3035 products of "Immunology and Inflammation"
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Fendosal
CAS:<p>Fendosal (HP-129), NSAID, 6.9-9.5x stronger than aspirin in chronic inflammation models.</p>Formula:C25H19NO3Purity:99.3%Color and Shape:SolidMolecular weight:381.42TMV-IN-5
CAS:<p>TMV-IN-5 (compound 1a) serves as an antiviral/antifungal agent, specifically targeting and inhibiting the assembly of the tobacco mosaic virus (TMV) by binding</p>Formula:C22H23N3SColor and Shape:SolidMolecular weight:361.5TLR7/8 agonist 9
CAS:<p>TLR7/8 agonist 9 (Compound 25a), exhibiting EC50 values of 40 nM and 23 nM for hTLR7 and hTLR8 respectively, demonstrates anti-tumor properties and enhances the</p>Formula:C20H26N6OColor and Shape:SolidMolecular weight:366.46Veledimex racemate
CAS:<p>Veledimex racemate, the racemic form of veledimex, is an orally available, small-molecule ligand that activates the RheoSwitch Therapeutic System.</p>Formula:C27H38N2O3Purity:98%Color and Shape:SolidMolecular weight:438.6Caspase-3 activator 1
<p>Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage.</p>Formula:C28H27N6O2RuS2Purity:98%Color and Shape:SolidMolecular weight:644.75(S)-BI 665915
CAS:<p>(S)-BI 665915 is an orally active inhibitor of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP)(IC50 of 1.7 nM for FLAP binding)..</p>Formula:C24H26N8O2Purity:98%Color and Shape:SolidMolecular weight:458.52AD 0261
CAS:<p>AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions.</p>Formula:C27H31F2N3OPurity:98%Color and Shape:SolidMolecular weight:451.55STING agonist-10
CAS:<p>STING agonist-10 is a potent activator of the STING small molecule cyclic urea class (EC50: 2600 nM).STING activation is a highly promising immunotherapy.</p>Formula:C25H20ClF4N3O2Color and Shape:SolidMolecular weight:505.89IKK-IN-1
CAS:<p>IKK-IN-1 is an inhibitor of IKK.</p>Formula:C22H26ClN3O4Purity:98%Color and Shape:SolidMolecular weight:431.91ACHP Hydrochloride
CAS:<p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>Formula:C21H25ClN4O2Purity:99.83%Color and Shape:SolidMolecular weight:400.9AHR antagonist 4
CAS:<p>AHR antagonist 4, potent with 82.2 nM IC50, inhibits AHR from patent WO2018146010A1 and shows anti-cancer properties.</p>Formula:C20H14F6N4O4Purity:98%Color and Shape:SolidMolecular weight:488.34BDW568
CAS:<p>BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist.</p>Formula:C12H12N4O2S2Color and Shape:SolidMolecular weight:308.38JNJ-67856633
CAS:<p>JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease .</p>Formula:C20H11F6N5O2Purity:99.87%Color and Shape:SolidMolecular weight:467.32(Rac)-BAY-985
CAS:<p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>Formula:C27H30F3N9OPurity:98%Color and Shape:SolidMolecular weight:553.58TMV-IN-3
CAS:<p>TMV-IN-3 is a chalcone derivative that inhibits TMV with a 120.3 μg/mL EC50, used in research on infection and cancer.</p>Formula:C28H26O4Color and Shape:SolidMolecular weight:426.5α-Pyridoin
CAS:<p>α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.</p>Formula:C12H12N2O2Color and Shape:SolidMolecular weight:216.24Lipid peroxidation inhibitor 1
CAS:<p>Lipid peroxidation inhibitor 1 is an inhibitor of lipid peroxidation (IC50: 0.07 μM).</p>Formula:C24H32N2OPurity:98%Color and Shape:SolidMolecular weight:364.52GW274150 phosphate
CAS:<p>GW274150 phosphate is a selective, orally active iNOS inhibitor with an IC50 of 0.2 μM. It mitigates experimental renal ischaemia-reperfusion injury.</p>Formula:C8H20N3O6PSPurity:98%Color and Shape:SolidMolecular weight:317.3CCG-63802
CAS:<p>CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.</p>Formula:C26H18N4O2SPurity:90%Color and Shape:SolidMolecular weight:450.51STING-IN-7
CAS:<p>STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of</p>Formula:C16H14ClN3OPurity:98%Color and Shape:SolidMolecular weight:299.76MALT1-IN-6
CAS:<p>MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.</p>Formula:C18H12Cl2F3N9OColor and Shape:SolidMolecular weight:498.25PROTAC IRAK4 degrader-8
CAS:<p>PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].</p>Formula:C43H50ClF2N11O5Purity:98%Color and Shape:SolidMolecular weight:874.38FEN1-IN-6
CAS:<p>FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and additionally</p>Formula:C12H8N2O5S2Purity:98%Color and Shape:SolidMolecular weight:324.33GSK840
CAS:<p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>Formula:C21H23N3O3Purity:99.7%Color and Shape:SolidMolecular weight:365.43Tyrosinase-IN-22
CAS:<p>Tyrosinase-IN-22 (compound 4) serves as a potent inhibitor for tyrosinase substrates, namely L-tyrosine and L-dopa, exhibiting inhibitory concentrations (IC50s) of 60 nM and 30 nM, respectively. Additionally, it demonstrates significant antioxidant and anti-melanogenic properties, making it suitable for related research endeavors [1].</p>Formula:C7H5ClN2SColor and Shape:SolidMolecular weight:184.64Anti-inflammatory agent 65
CAS:<p>Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation</p>Formula:C49H71NO6S2Purity:98%Color and Shape:SoildMolecular weight:834.22Factor D inhibitor 6
CAS:<p>Factor D inhibitor 6 is a potent, highly selective, and orally active compound that specifically inhibits the activity of factor D (FD) with an IC50 of 30 nM and a Kd of 6 nM. It does not exhibit inhibitory effects against factor B, classical and lectin complement-pathway activation, or a broad array of receptors, ion channels, kinases, and proteases.</p>Formula:C23H22ClFN6O3Color and Shape:SolidMolecular weight:484.92GW274150 dihydrochloride
CAS:<p>GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-</p>Formula:C8H19Cl2N3O2SPurity:98%Color and Shape:SolidMolecular weight:292.23TLR7 agonist 15
CAS:<p>TLR7 agonist 15 (compound 16b) is a potent activator of mouse macrophages and hPBMCs, demonstrating an EC50 of 18 nM.</p>Formula:C26H31N5OColor and Shape:SolidMolecular weight:429.56CAY10464
CAS:<p>CAY10464 (AHR antagonist 7) is an AHR antagonist for the study of cancer and metabolic diseases.</p>Formula:C15H12Cl2OPurity:99.96%Color and Shape:SolidMolecular weight:279.16IR-Crizotinib
CAS:<p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>Formula:C53H57Cl2FIN7OPurity:98%Color and Shape:SolidMolecular weight:1024.88Cergutuzumab amunaleukin
CAS:<p>Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with anti-tumor activity.</p>Purity:98% (SDS-PAGE); 99.7% (SEC-HPLC) - 98% (SDS-PAGE); 99.7% (SEC-HPLC)Color and Shape:LiquidMolecular weight:162.05 kDaIL-17A antagonist 3
CAS:<p>IL-17A antagonist 3 is an IL-17A antagonist.</p>Formula:C33H33ClN6O4Purity:98%Color and Shape:SolidMolecular weight:613.11RIPK1-IN-16
CAS:<p>RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.</p>Formula:C20H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:393.46STING agonist-11
CAS:<p>STING agonist-11 is a potent activator of the small molecule cyclic urea class of STING (EC50: 18 nM).STING activation is a highly promising immunotherapy.</p>Formula:C25H20ClF4N3O2Color and Shape:SolidMolecular weight:505.89Oxidized ATP trisodium salt
CAS:<p>Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (</p>Formula:C10H11N5Na3O13P3Purity:98%Color and Shape:SolidMolecular weight:571.11PDE4-IN-8
CAS:<p>PDE4-IN-8 is a potent PDE4 inhibitor with IC50 0.93 nM for PDE4B2 and minor impact on IL13, IL4, IFNy (IC50: 4.04, 36.33, 2394 nM).</p>Formula:C18H22BNO4Color and Shape:SolidMolecular weight:327.18MKA031
CAS:<p>MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM.</p>Formula:C21H17N5O2SColor and Shape:SolidMolecular weight:403.46IRAK4-IN-6
CAS:<p>IRAK4-IN-6 is an oral IRAK4 inhibitor with a 4 nM IC50, targeting MyD88 L265P mutant DLBCL.</p>Formula:C25H32N10O2Purity:98%Color and Shape:SolidMolecular weight:504.59TLR9-IN-1
CAS:<p>TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.</p>Formula:C23H31N7OColor and Shape:SolidMolecular weight:421.54Leteprinim
CAS:<p>Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from</p>Formula:C15H13N5O4Purity:99.08%Color and Shape:SolidMolecular weight:327.29FEN1-IN-7
CAS:<p>FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells.</p>Formula:C16H14N2O6SPurity:98%Color and Shape:SolidMolecular weight:362.36Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767WEHI-345
CAS:<p>WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.</p>Formula:C22H23N7OPurity:>99.99%Color and Shape:SolidMolecular weight:401.46GGTI 2147
CAS:<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Formula:C28H30N4O3Purity:98.69%Color and Shape:SolidMolecular weight:470.56BRP-201
CAS:<p>BRP-201: selective mPGES-1 inhibitor (IC50: 0.42 μM), potential next-gen anti-inflammatory drug.</p>Formula:C28H27ClN4OSColor and Shape:SolidMolecular weight:503.06Vipoglanstat
CAS:<p>Vipoglanstat: inhibits prostaglandin E synthase, anti-inflammatory, reduces leukocyte infiltration and lung injury from endotoxin/sepsis.</p>Formula:C30H34Cl2F5N5O3Color and Shape:SolidMolecular weight:678.52FEN1-IN-5
CAS:<p>FEN1-IN-5 (compound 12A) is a potent Flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 12 nM, playing a role in DNA repair mechanisms [1].</p>Formula:C21H17N3O4SPurity:98%Color and Shape:SolidMolecular weight:407.44EG01377
CAS:<p>EG01377 is a NRP1 antagonist with antiangiogenic, antimigratory, and antitumor activity, Kd 1.32 μM, IC50s 609 nM for NRP1-a1/b1, inactive on NRP2.</p>Formula:C26H30N6O6S2Purity:98%Color and Shape:SolidMolecular weight:586.68TLR7 agonist 16
CAS:<p>TLR7 agonist 16 (compound 16d) is a potent activator of TLR7 with an EC50 value of 18 nM.</p>Formula:C25H29N5O2Color and Shape:SolidMolecular weight:431.53STING modulator-3
CAS:<p>STING modulator-3, a 43.1 nM R232 STING inhibitor, doesn't affect IRF-3 or TNF-β in THP-1 cells.</p>Formula:C18H17N9OColor and Shape:SolidMolecular weight:375.39cGAS-IN-1
CAS:<p>cGAS-IN-1 (compound C20), a flavonoid that acts as a Cyclic GMP-AMP Synthase (cGAS) inhibitor, demonstrates IC50 values of 2.28 μM for human cGAS and 1.44 μM</p>Formula:C18H19NO8Color and Shape:SolidMolecular weight:377.35Nrf2-IN-3
CAS:<p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>Formula:C22H26N4O4SPurity:98.07%Color and Shape:SolidMolecular weight:442.53ABR-238901
CAS:<p>ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products</p>Formula:C11H9BrClN3O4SPurity:98.63% - 98.71%Color and Shape:SolidMolecular weight:394.63LTβR-IN-1
CAS:<p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>Formula:C18H16N4O2Purity:98.93%Color and Shape:SolidMolecular weight:320.35Iptacopan
CAS:<p>Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM. Cost-effective and quality-assured.</p>Formula:C25H30N2O4Purity:99.07% - >99.99%Color and Shape:SolidMolecular weight:422.52Xanthine oxidase-IN-10
CAS:<p>Xanthine oxidase-IN-10 (XO8 analog) is a xanthine oxidase (XO) inhibitor for the study of gout.</p>Formula:C10H8N2OSPurity:99.16%Color and Shape:SolidMolecular weight:204.25AVP-13358
CAS:<p>AVP-13358: a CD23/IgE inhibitor for treating immune, infection, and ENT disorders.</p>Formula:C30H29N5O2Purity:98.42%Color and Shape:SolidMolecular weight:491.58ERDRP-0519
CAS:<p>ERDRP-0519 is an oral measles polymerase inhibitor, preventing disease in monkeys, with potent nanomolar efficacy against morbilliviruses.</p>Formula:C23H30F3N5O4SPurity:98.64% - 98.71%Color and Shape:SolidMolecular weight:529.58CU-CPD107
CAS:<p>CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.</p>Formula:C16H21IN2O2Purity:98%Color and Shape:SolidMolecular weight:400.25Sembragiline
CAS:<p>Sembragiline (EVT-302) is a selective MAO-B inhibitor for the study of Alzheimer's disease (AD).</p>Formula:C19H19FN2O3Purity:99.49% - 99.49%Color and Shape:SolidMolecular weight:342.36RIPK1-IN-4
CAS:<p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>Formula:C23H23N5O2Purity:99.94%Color and Shape:SolidMolecular weight:401.46Netakimab
CAS:<p>Netakimab (BCD 085) is a monoclonal antibody targeting interleukin-17A and can be used to study spondyloarthritis.</p>Purity:95%Color and Shape:LiquidMolecular weight:145.74 kDaGW274150
CAS:<p>GW274150: selective oral iNOS inhibitor (Kd=40 nM), low activity on eNOS/nNOS, protective in acute lung injury.</p>Formula:C8H17N3O2SPurity:96.43%Color and Shape:SolidMolecular weight:219.3IL-17 modulator 4
CAS:<p>IL-17 modulator 4 is a prodrug of IL-17 modulator 1, which acts as a potent modulator of IL-17.Cost-effective and quality-assured.</p>Formula:C27H34N6O2Purity:99.59%Color and Shape:SolidMolecular weight:474.6Piflufolastat
CAS:<p>Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA.</p>Formula:C18H23FN4O8Purity:98.98%Color and Shape:SolidMolecular weight:442.4Antiviral agent 34
CAS:<p>Antiviral Agent 34 is an antiviral compound that inhibits influenza virus and inhibits the proliferation of influenza virus by modulating RNA polymerase.</p>Formula:C29H33N3O2SPurity:99.51%Color and Shape:SoildMolecular weight:487.66Usnoflast
CAS:<p>Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.</p>Formula:C21H29N3O3SPurity:98.79%Color and Shape:SolidMolecular weight:403.54Supercinnamaldehyde
CAS:<p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>Formula:C12H11NO2Purity:98.89%Color and Shape:SolidMolecular weight:201.22GB1107
CAS:<p>GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.</p>Formula:C20H16Cl2F3N3O4SPurity:98.33% - 99.87%Color and Shape:SolidMolecular weight:522.32Oditrasertib
CAS:<p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>Formula:C14H15F2N3O2Purity:98.65% - 99.65%Color and Shape:SolidMolecular weight:295.28ADS032
CAS:<p>ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity for the study of respiratory inflammation or infection.</p>Formula:C22H29NO4SPurity:98.37%Color and Shape:SolidMolecular weight:403.54(±)-CPSI-1306
CAS:<p>(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can</p>Formula:C15H16F2N2O3Purity:97.46%Color and Shape:SolidMolecular weight:310.3COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Formula:C25H21N3O3SColor and Shape:SolidMolecular weight:443.52MG-T-19
CAS:<p>MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.</p>Formula:C18H8Br2ClF3N4O2SPurity:99.14%Color and Shape:SolidMolecular weight:596.6CVN293
CAS:<p>CVN293 is a inhibitor of the potassium channel KCNK13,BBB,It inhibits the production of the pro-inflammatory cytokine IL-1β induced by NLRP3 in microglia</p>Formula:C14H10FN7OPurity:99.50%Color and Shape:SolidMolecular weight:311.27Heme Oxygenase-1-IN-2
<p>Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.</p>Formula:C19H18ClN3OColor and Shape:SolidMolecular weight:339.82C-di-IMP
CAS:<p>Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.</p>Formula:C20H22N8O14P2Color and Shape:SolidMolecular weight:660.38NLRP3-IN-80
CAS:<p>NLRP3-IN-80 (Compound 1) is an NLRP3 inhibitor useful for research into inflammatory aging.</p>Formula:C24H22F2N4O3Color and Shape:SolidMolecular weight:452.45Galectin-3-IN-3
CAS:<p>Galectin-3-IN-3 (Compound 4) serves as a selective and orally active inhibitor targeting Gal-3. It exhibits IC50 values of 11 nM for mGal-3 and 84 nM for hGal-3 [1].</p>Formula:C25H22ClF2N7O4SColor and Shape:SolidMolecular weight:590.00MMG-11 quarterhydrate
<p>MMG-11 quarterhydrate, a potent hTLR2 antagonist, inhibits TLR2/1 and TLR2/6 with IC50s of 1.7μM and 5.7μM; low toxicity.</p>Formula:C15H16O8Color and Shape:SolidMolecular weight:310.78PB01
CAS:<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Formula:C18H21N5O3Color and Shape:SolidMolecular weight:355.391ALR-6
CAS:<p>ALR-6, an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP, possesses anti-inflammatory properties. It significantly inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without substantially affecting direct inhibition of 5-LOX [1].</p>Formula:C18H14O5Color and Shape:SolidMolecular weight:310.3AhR agonist 7
CAS:<p>Compound 8, an AhR agonist 7, demonstrates potent activation of AhR with an EC50 of 13nM [1].</p>Formula:C16H15ClFNO2Color and Shape:SolidMolecular weight:307.75(Rel)-Factor B-IN-5
CAS:<p>(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.</p>Formula:C27H32N2O4Purity:>99.99%Color and Shape:SolidMolecular weight:448.55COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formula:C17H19NO3Color and Shape:SolidMolecular weight:285.34XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formula:C24H20N4O2SColor and Shape:SolidMolecular weight:428.51Ac5GalNTGc
CAS:<p>Ac5GalNTGc, an analog of hexosamine, inhibits mucin-type O-linked glycosylation biosynthesis [1].</p>Formula:C18H25NO11SColor and Shape:SolidMolecular weight:463.46Factor B-IN-4
CAS:<p>Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.</p>Formula:C27H32N2O4Color and Shape:SolidMolecular weight:448.55Polvitolimod
CAS:<p>Polvitolimod is a TLR7 agonist used to treat infectious disease and cancer.</p>Formula:C13H14FN5O4Color and Shape:SolidMolecular weight:323.28ODN 2088
CAS:<p>ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.</p>Color and Shape:SolidTLR7/8 antagonist 2
<p>TLR7/8 antagonist 2: potent, orally active, IC50: 4.9 nM (TLR7), 0.6 nM (TLR8); potential for lupus therapy research.</p>Formula:C22H26FN5Color and Shape:SolidMolecular weight:379.47YE6144
CAS:<p>YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can Trust</p>Formula:C21H27ClFN7OColor and Shape:SolidMolecular weight:447.94Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formula:C17H13BrN4O3S2Color and Shape:SolidMolecular weight:465.34COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formula:C19H18N2O5SColor and Shape:SolidMolecular weight:386.42Galectin-3-IN-4
CAS:<p>Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].</p>Formula:C24H22ClF2N5O5SColor and Shape:SolidMolecular weight:565.98IKZF1-degrader-1
CAS:<p>IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].</p>Formula:C35H29F2N5O3Color and Shape:SolidMolecular weight:605.63Corannulene
CAS:<p>Corannulene is an agonist of the aromatic hydrocarbon receptor (AhR). It induces a lower cytotoxic response in liver cancer cells compared to Benzo[a]pyrene and shows potential for use in cancer research.</p>Formula:C20H10Color and Shape:SolidMolecular weight:250.293AS2690168 hydrochloride
CAS:<p>AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formula:C17H15Cl2F3N4OColor and Shape:SolidMolecular weight:419.228MAY0132
CAS:<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Formula:C16H15ClF3NColor and Shape:SolidMolecular weight:313.745
