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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3034 products of "Immunology and Inflammation"

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  • CymitQuimica logo
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    Anti-inflammatory agent 6

    <p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>
    Formula:C22H20O12
    Color and Shape:Solid
    Molecular weight:476.39

    Ref: TM-T63107

  • Anti-inflammatory agent 102
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    Anti-inflammatory agent 102

    CAS:
    <p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>
    Formula:C16H16ClN3O3
    Color and Shape:Solid
    Molecular weight:333.77

    Ref: TM-T207168

  • SMW139
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    SMW139

    CAS:
    <p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>
    Formula:C19H21ClF3NO2
    Color and Shape:Solid
    Molecular weight:387.824

    Ref: TM-T206318

  • MALT1-IN-11
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    MALT1-IN-11

    CAS:
    <p>MALT1-IN-11: MALT1 inhibitor, IC50 &lt;10-100 nM, reduces IL10, for cancer/autoimmune research.</p>
    Formula:C20H16F4N8O
    Color and Shape:Solid
    Molecular weight:460.39

    Ref: TM-T73019

  • TMC353121
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    TMC353121

    CAS:
    <p>TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).</p>
    Formula:C32H42N6O3
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:558.71

    Ref: TM-T17107

  • YM-I-26
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    YM-I-26

    CAS:
    <p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>
    Formula:C28H33ClN2O5S2
    Color and Shape:Solid
    Molecular weight:577.16

    Ref: TM-T200649

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    COX-2-IN-9

    <p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>
    Formula:C25H23N5O4S2
    Color and Shape:Solid
    Molecular weight:521.61

    Ref: TM-T63646

  • SLC7A11-IN-2
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    SLC7A11-IN-2

    CAS:
    <p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>
    Formula:C19H24N4O3
    Color and Shape:Solid
    Molecular weight:356.42

    Ref: TM-T200659

  • Nrf2 activator-6
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    Nrf2 activator-6

    CAS:
    <p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>
    Formula:C31H37ClFN5O5
    Color and Shape:Solid
    Molecular weight:614.11

    Ref: TM-T72697

  • AIM4
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    AIM4

    CAS:
    <p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>
    Formula:C25H23Br2N5O4
    Color and Shape:Solid
    Molecular weight:617.289

    Ref: TM-T206489

  • SP4206
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    SP4206

    CAS:
    <p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>
    Formula:C30H37Cl2N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:662.56

    Ref: TM-T12982

  • NOD1-IN-1
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    NOD1-IN-1

    CAS:
    <p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>
    Formula:C16H14ClN3O3
    Color and Shape:Solid
    Molecular weight:331.75

    Ref: TM-T200671

  • G108
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    G108

    CAS:
    <p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>
    Formula:C16H14Cl2N4O2
    Purity:99.13% - 99.75%
    Color and Shape:Solid
    Molecular weight:365.21

    Ref: TM-T69663

  • α-Gracinoic acid
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    α-Gracinoic acid

    CAS:
    <p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>
    Formula:C29H42O4
    Color and Shape:Solid
    Molecular weight:454.64

    Ref: TM-T200464

  • NOTA-FAPI
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    NOTA-FAPI

    CAS:
    <p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>
    Formula:C36H47F2N9O8
    Purity:99.748%
    Color and Shape:Solid
    Molecular weight:771.81

    Ref: TM-T69660

  • SARM1-IN-4
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    SARM1-IN-4

    CAS:
    <p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>
    Formula:C13H17F2N3O2
    Color and Shape:Solid
    Molecular weight:285.29

    Ref: TM-T206825

  • CymitQuimica logo
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    COX-2/PI3K-IN-1

    <p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>
    Formula:C19H14ClN5S2
    Color and Shape:Solid
    Molecular weight:411.93

    Ref: TM-T62103

  • LHC-165
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    LHC-165

    CAS:
    <p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>
    Formula:C29H32F2N3O7P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.55

    Ref: TM-T15751

  • IRAK4-IN-15
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    IRAK4-IN-15

    CAS:
    <p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>
    Formula:C25H29FN10
    Color and Shape:Solid
    Molecular weight:488.56

    Ref: TM-T63262

  • CD73-IN-18
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    CD73-IN-18

    CAS:
    <p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>
    Formula:C20H17N5O3
    Color and Shape:Solid
    Molecular weight:375.38

    Ref: TM-T200672