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Immunology and Inflammation

Immunology and Inflammation

Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.

Subcategories of "Immunology and Inflammation"

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Found 3035 products of "Immunology and Inflammation"

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  • SBI-0640726
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    SBI-0640726

    CAS:
    <p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>
    Formula:C23H15ClN2O2
    Color and Shape:Solid
    Molecular weight:386.83

    Ref: TM-T89836

  • IRAK4 modulator-1
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    IRAK4 modulator-1

    CAS:
    <p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>
    Formula:C19H13ClN4O2
    Color and Shape:Solid
    Molecular weight:364.79

    Ref: TM-T86740

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    TIM-3-IN-1

    <p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>
    Formula:C20H16ClN7O3S
    Color and Shape:Solid
    Molecular weight:469.9

    Ref: TM-T63029

  • IKZF1-degrader-2
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    IKZF1-degrader-2

    CAS:
    <p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>
    Formula:C33H30FN5O5
    Color and Shape:Solid
    Molecular weight:595.62

    Ref: TM-T86708

  • SB24011
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    SB24011

    CAS:
    <p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>
    Formula:C34H38N4O7
    Color and Shape:Solid
    Molecular weight:614.69

    Ref: TM-T87367

  • 6-Alkyne-F-araNAD
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    6-Alkyne-F-araNAD

    CAS:
    <p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>
    Formula:C24H28FN7O13P2
    Color and Shape:Solid
    Molecular weight:703.464

    Ref: TM-T206560

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    NF-κB-IN-6

    <p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>
    Formula:C14H20N2O3
    Color and Shape:Solid
    Molecular weight:264.32

    Ref: TM-T60433

  • IRAK4 ligand-13
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    IRAK4 ligand-13

    CAS:
    <p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>
    Formula:C23H26N10
    Color and Shape:Solid
    Molecular weight:442.52

    Ref: TM-T206695

  • BAA473
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    BAA473

    <p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>
    Formula:C36H62O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:574.87

    Ref: TM-T10447

  • Fexlamose
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    Fexlamose

    CAS:
    <p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>
    Formula:C12H22O9S2
    Color and Shape:Solid
    Molecular weight:374.428

    Ref: TM-T206116

  • Hypoxystat
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    Hypoxystat

    CAS:
    <p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>
    Formula:C21H21NO5
    Color and Shape:Solid
    Molecular weight:367.395

    Ref: TM-T205665

  • IACS-8779
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    IACS-8779

    CAS:
    <p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>
    Formula:C21H25N9O10P2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:689.55

    Ref: TM-T11595

  • STING agonist-42
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    STING agonist-42

    CAS:
    <p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>
    Formula:C17H8F2LiN5O3
    Color and Shape:Solid
    Molecular weight:375.22

    Ref: TM-T207376

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    NLRP3-IN-4

    <p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>
    Formula:C22H22N2O5
    Color and Shape:Solid
    Molecular weight:394.42

    Ref: TM-T61826

  • Balsalazide disodium
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    Balsalazide disodium

    CAS:
    <p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>
    Formula:C17H13N3Na2O6
    Color and Shape:Solid
    Molecular weight:401.281

    Ref: TM-T204584

  • TE-11
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    TE-11

    CAS:
    <p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>
    Formula:C16H13NO
    Color and Shape:Solid
    Molecular weight:235.28

    Ref: TM-T207303

  • ALR-27
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    ALR-27

    CAS:
    <p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (&gt;80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>
    Formula:C19H22O3
    Color and Shape:Solid
    Molecular weight:298.38

    Ref: TM-T85637

  • Itaconic acid prodrug-1
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    Itaconic acid prodrug-1

    CAS:
    <p>Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.</p>
    Formula:C15H22O10
    Color and Shape:Solid
    Molecular weight:362.329

    Ref: TM-T204591

  • K-14585
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    K-14585

    CAS:
    <p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>
    Formula:C51H56Cl2N8O4
    Color and Shape:Solid
    Molecular weight:915.95

    Ref: TM-T27708

  • AS2690168 (free base)
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    AS2690168 (free base)

    CAS:
    <p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>
    Formula:C17H13F3N4O
    Color and Shape:Solid
    Molecular weight:346.306

    Ref: TM-T204137