Pim
Pim kinases are a family of serine/threonine kinases that play a key role in cell survival, proliferation, and apoptosis. These kinases are downstream effectors in the JAK/STAT signaling pathway and are involved in various physiological processes, including immune responses and hematopoiesis. Overexpression of Pim kinases has been associated with the development of cancer, making them important targets for therapeutic intervention. At CymitQuimica, we offer a variety of high-quality Pim kinase inhibitors and modulators to support your research in oncology, cell biology, and signal transduction.
Found 32 products of "Pim"
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Uzansertib phosphate
CAS:<p>Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.</p>Formula:C26H29F3N5O7PPurity:99.75% - 99.79%Color and Shape:SolidMolecular weight:611.51Pim-1 kinase inhibitor 8
CAS:<p>Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.</p>Formula:C14H17N3O3Purity:99.81%Color and Shape:SoildMolecular weight:275.3R8-T198wt
CAS:<p>Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.</p>Formula:C111H211N59O26SPurity:98%Color and Shape:SolidMolecular weight:2820.33Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Color and Shape:Odour SolidVB1080
<p>VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.</p>Formula:C27H27N3O3Color and Shape:SolidMolecular weight:441.522Pim-1/2 kinase inhibitor 1
CAS:<p>Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.</p>Formula:C11H9NO3SPurity:99.78%Color and Shape:SolidMolecular weight:235.26HJ-PI01
CAS:<p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>Formula:C14H11NO2Purity:98.92%Color and Shape:SolidMolecular weight:225.24AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48(Z)-SMI-4a
CAS:<p>(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.</p>Formula:C11H6F3NO2SPurity:97.66% - 99.93%Color and Shape:SolidMolecular weight:273.23TCS-PIM-1-4a
CAS:<p>SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).</p>Formula:C11H6F3NO2SPurity:99.89%Color and Shape:SolidMolecular weight:273.23SMI-16a
CAS:<p>SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (</p>Formula:C13H13NO3SPurity:99.99%Color and Shape:SolidMolecular weight:263.31Quercetagetin
CAS:<p>Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.</p>Formula:C15H10O8Purity:99.65% - 99.91%Color and Shape:SolidMolecular weight:318.24Hispidulin
CAS:<p>Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).</p>Formula:C16H12O6Purity:98.53% - 99.87%Color and Shape:SolidMolecular weight:300.26SGI-1776
CAS:<p>SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.</p>Formula:C20H22F3N5OPurity:99.3% - >99.99%Color and Shape:SolidMolecular weight:405.42Pim1/AKK1-IN-1
CAS:<p>Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.</p>Formula:C20H13N5OPurity:97.03% - 98.69%Color and Shape:SolidMolecular weight:339.35TCS PIM-1 1
CAS:<p>TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.</p>Formula:C18H11BrN2O2Purity:97% - 97.98%Color and Shape:SolidMolecular weight:367.2TP-3654
CAS:<p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>Formula:C22H25F3N4OPurity:99.8% - 99.95%Color and Shape:SolidMolecular weight:418.46CX-6258 hydrochloride
CAS:<p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>Formula:C26H24ClN3O3·HClPurity:96.03% - 98.60%Color and Shape:SolidMolecular weight:498.4K00135
CAS:<p>K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.</p>Formula:C18H18N4OPurity:98.16%Color and Shape:SolidMolecular weight:306.36CX-6258
CAS:<p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>Formula:C26H24ClN3O3Purity:97.46%Color and Shape:SolidMolecular weight:461.94
