MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
NUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Color and Shape:Odour SolidTUS-007
CAS:<p>TUS-007, a non-proteasome inhibiting CANDDY, is an oral KRAS G12D/V degrader for cell-free chemical knockdown and tumor suppression.</p>Formula:C44H54Cl2N8O5Color and Shape:SolidMolecular weight:845.86RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formula:C30H55BrN2O3Color and Shape:SolidMolecular weight:571.685PROTAC KRAS G12C degrader-1
<p>PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells</p>Formula:C50H54ClFN8O6Purity:98%Color and Shape:SolidMolecular weight:917.47SOS1-IN-17
<p>SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.</p>Formula:C29H34F3N5O2Color and Shape:SolidMolecular weight:541.61KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Formula:C33H39ClF2N6O3Color and Shape:SolidMolecular weight:641.15G12Si-5
CAS:<p>G12Si-5: covalent K-RasG12S inhibitor, Ki 26 μM, targets S-IIP domain, hinders oncogenic signaling, lowers ERK phosphorylation in mutant cells.</p>Formula:C31H29ClFN5O3Color and Shape:SolidMolecular weight:574.05HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formula:C26H27N7O2Color and Shape:SolidMolecular weight:469.54YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Purity:98%Color and Shape:Odour SolidPROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Formula:C46H55F2N9O9SColor and Shape:SolidMolecular weight:948.05PROTAC MEK1 Degrader-1
CAS:<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Formula:C53H66FIN8O11S2Purity:98%Color and Shape:SolidMolecular weight:1201.17KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formula:C32H37ClN8O2Color and Shape:SolidMolecular weight:601.15KRpep-2d
CAS:<p>KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.</p>Formula:C109H183N43O25S2Color and Shape:SolidMolecular weight:2560.02(+)-Oxanthromicin
CAS:<p>(+)-Oxanthromicin, an enantiomer of the rare Streptomyces metabolite (−)-oxanthromicin, demonstrates inhibitory activity against K-Ras plasma membrane localization in MDCK cells, exhibiting an IC50 value of 62.5 μM.</p>Formula:C36H30O12Color and Shape:SolidMolecular weight:654.624BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Formula:C47H62N8O4SColor and Shape:SolidMolecular weight:835.11Debromohymenialdisine
CAS:<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Formula:C11H11N5O2Color and Shape:SolidMolecular weight:245.242D-JNKI-1
CAS:<p>D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.</p>Formula:C164H286N66O40Purity:98%Color and Shape:SolidMolecular weight:3822.44KRAS inhibitor-24
CAS:<p>KRAS inhibitor-24 (compound 115c), a pyrido-pyridine class KRAS inhibitor, exhibits potent activity against KRas G12V, KRas WT, and KRas G12R, with IC50 values all below 100 nM.</p>Formula:C33H39ClF2N6O3Color and Shape:SolidMolecular weight:641.15p38 MAP Kinase Inhibitor Ⅵ
CAS:<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Formula:C16H13FN2OS2Purity:98.53%Color and Shape:SolidMolecular weight:332.42G12 TFA
<p>G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.</p>Formula:C54H96F3N15O17Molecular weight:1283.70607
