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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • pan-KRAS-IN-2
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    pan-KRAS-IN-2

    CAS:
    <p>Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D</p>
    Formula:C34H34F2N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:584.66

    Ref: TM-T79800

  • SB-682330A
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    SB-682330A

    CAS:
    <p>SB-682330A is a Raf kinase inhibitor.</p>
    Formula:C28H27N3O3
    Color and Shape:Solid
    Molecular weight:453.53

    Ref: TM-T62781

  • TC13172
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    TC13172

    CAS:
    <p>TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.</p>
    Formula:C17H16N4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:388.4

    Ref: TM-T17010

  • KRAS degrader-1
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    KRAS degrader-1

    CAS:
    <p>KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].</p>
    Formula:C55H57Br2ClFIN8O7
    Color and Shape:Solid
    Molecular weight:1283.25

    Ref: TM-T79147

  • Cobimetinib racemate
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    Cobimetinib racemate

    CAS:
    <p>Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated</p>
    Formula:C21H21F3IN3O2
    Purity:98.00% - 99.71%
    Color and Shape:Solid
    Molecular weight:531.31

    Ref: TM-T22677

  • Kras binder 12
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    Kras binder 12

    CAS:
    <p>Kras binder 12 can be used in studies about Ras.</p>
    Formula:C29H47N9O6
    Color and Shape:Soild
    Molecular weight:617.74

    Ref: TM-T77808

  • ARQ-736
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    ARQ-736

    CAS:
    <p>ARQ 736 effectively targets and inhibits BRAF, crucial in MAPK pathway, beneficial for treating melanomas and certain colon cancers.</p>
    Formula:C25H25N8Na2O8PS
    Color and Shape:Solid
    Molecular weight:674.54

    Ref: TM-T71184

  • Ilaprazole sodium hydrate
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    Ilaprazole sodium hydrate

    CAS:
    <p>Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.</p>
    Formula:C19H21N4NaO4S
    Purity:99.2%
    Color and Shape:Solid
    Molecular weight:424.45

    Ref: TM-T78218

  • KRAS G12C inhibitor 17
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    KRAS G12C inhibitor 17

    CAS:
    <p>KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.</p>
    Formula:C24H20ClF2N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:471.88

    Ref: TM-T11771

  • ARS-1323-alkyne
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    ARS-1323-alkyne

    CAS:
    <p>ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.</p>
    Formula:C28H27ClF2N6O3
    Purity:98.00% - 99%
    Color and Shape:Solid
    Molecular weight:569

    Ref: TM-T10374

  • ERK1/2 inhibitor 5
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    ERK1/2 inhibitor 5

    CAS:
    <p>ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.</p>
    Formula:C28H32ClFN6O5
    Color and Shape:Solid
    Molecular weight:587.04

    Ref: TM-T64155

  • ARS-1323
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    ARS-1323

    CAS:
    <p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>
    Formula:C21H17ClF2N4O2
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:430.84

    Ref: TM-T10375

  • KRAS G12C inhibitor 32
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    KRAS G12C inhibitor 32

    CAS:
    <p>KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].</p>
    Formula:C29H30Cl3FN6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:635.94

    Ref: TM-T72335

  • TH-Z827
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    TH-Z827

    CAS:
    <p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>
    Formula:C30H38N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.66

    Ref: TM-T79092

  • HPK1-IN-9
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    HPK1-IN-9

    CAS:
    <p>HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)</p>
    Formula:C30H33N7O2
    Color and Shape:Solid
    Molecular weight:523.63

    Ref: TM-T63670

  • CHI-000-667
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    CHI-000-667

    CAS:
    <p>CHI-000-667 can be used in studies about Ras.</p>
    Formula:C21H16ClNO4S
    Color and Shape:Solid
    Molecular weight:413.87

    Ref: TM-T77807

  • KRAS G12C inhibitor 28
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    KRAS G12C inhibitor 28

    CAS:
    <p>KRAS G12C Inhibitor 28 is a compound that effectively inhibits the KRAS G12C mutation, exhibiting potent antitumor effects with an inhibitory concentration (</p>
    Formula:C33H36F2N5O4P
    Color and Shape:Solid
    Molecular weight:635.64

    Ref: TM-T72334

  • K-Ras G12C-IN-2
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    K-Ras G12C-IN-2

    CAS:
    <p>K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.</p>
    Formula:C21H27ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:418.92

    Ref: TM-T11736

  • SHP2-IN-22
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    SHP2-IN-22

    CAS:
    <p>SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-</p>
    Formula:C23H22Cl2N8O
    Color and Shape:Solid
    Molecular weight:497.38

    Ref: TM-T78896

  • KRAS G12C inhibitor 40
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    KRAS G12C inhibitor 40

    CAS:
    <p>KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).</p>
    Formula:C34H36ClFN10O2
    Color and Shape:Solid
    Molecular weight:671.17

    Ref: TM-T72343