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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • ERK1/2 inhibitor 1
    Targetmol
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    ERK1/2 inhibitor 1

    CAS:
    <p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>
    Formula:C29H32ClN5O4
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:550.05

    Ref: TM-T11226

  • PF-05381941
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    PF-05381941

    CAS:
    <p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>
    Formula:C27H26N6O2
    Purity:98.04%
    Color and Shape:Solid
    Molecular weight:466.53

    Ref: TM-T36017

  • MEK-IN-1
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    MEK-IN-1

    CAS:
    <p>MEK-IN-1 is a MEK inhibitor.</p>
    Formula:C24H20N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.44

    Ref: TM-T10675

  • PAF (C16)
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    PAF (C16)

    CAS:
    <p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>
    Formula:C26H54NO7P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:523.68

    Ref: TM-T21547

  • B-Raf IN 13
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    B-Raf IN 13

    CAS:
    <p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>
    Formula:C19H19ClFN3O4S
    Purity:99.41% - >99.99%
    Color and Shape:Soild
    Molecular weight:439.89

    Ref: TM-T67862

  • KRAS G12D inhibitor 10
    Targetmol
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    KRAS G12D inhibitor 10

    CAS:
    <p>KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).</p>
    Formula:C33H41ClN8O2
    Color and Shape:Solid
    Molecular weight:617.18

    Ref: TM-T72345

  • GGTI-286
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    GGTI-286

    CAS:
    <p>GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.</p>
    Formula:C23H31N3O3S
    Color and Shape:Solid
    Molecular weight:429.58

    Ref: TM-T62379

  • MCP110
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    MCP110

    CAS:
    <p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>
    Formula:C33H36N2O3
    Purity:97.23%
    Color and Shape:Oil
    Molecular weight:508.65

    Ref: TM-T24437

  • KYA1797
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    KYA1797

    CAS:
    <p>KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.</p>
    Formula:C17H12N2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.42

    Ref: TM-T27760

  • RSK2-IN-2
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    RSK2-IN-2

    CAS:
    <p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>
    Formula:C16H11N5O
    Color and Shape:Solid
    Molecular weight:289.29

    Ref: TM-T60585

  • GABAB receptor antagonist 1
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    GABAB receptor antagonist 1

    CAS:
    <p>(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective</p>
    Formula:C18H24O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:304.38

    Ref: TM-T11350

  • B-Raf IN 8
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    B-Raf IN 8

    CAS:
    <p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast &amp; prostate cancer with IC50s from 9.78 to 29.85 μM.</p>
    Formula:C18H17N3O2
    Color and Shape:Solid
    Molecular weight:307.35

    Ref: TM-T60727

  • HPK1-IN-24
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    HPK1-IN-24

    CAS:
    <p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>
    Formula:C19H14FN5
    Color and Shape:Solid
    Molecular weight:331.35

    Ref: TM-T60973

  • UC-857993
    Targetmol
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    UC-857993

    CAS:
    <p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>
    Formula:C25H22ClNO2
    Color and Shape:Solid
    Molecular weight:403.9

    Ref: TM-T69195

  • JNK3 inhibitor-2
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    JNK3 inhibitor-2

    CAS:
    <p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (&gt;100 μM); targets DDR1 and EGFR mutations.</p>
    Formula:C20H14N2O2
    Color and Shape:Solid
    Molecular weight:314.34

    Ref: TM-T60805

  • Tpl2 Kinase Inhibitor 1
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    Tpl2 Kinase Inhibitor 1

    CAS:
    <p>Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.</p>
    Formula:C21H14ClFN6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.83

    Ref: TM-T17145

  • SX 011
    Targetmol
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    SX 011

    CAS:
    <p>SX 011 is a p38α inhibitor.</p>
    Formula:C26H27ClFN3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:483.96

    Ref: TM-T23408

  • KRAS inhibitor-7
    Targetmol
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    KRAS inhibitor-7

    CAS:
    <p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>
    Formula:C26H27ClF2N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.98

    Ref: TM-T11774

  • HPK1-IN-25
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    HPK1-IN-25

    CAS:
    <p>HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.</p>
    Formula:C23H25N5O
    Color and Shape:Solid
    Molecular weight:387.48

    Ref: TM-T61733

  • KRAS G12C inhibitor 43
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    KRAS G12C inhibitor 43

    CAS:
    <p>KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50&gt;1μM).</p>
    Formula:C33H35N7O3
    Color and Shape:Solid
    Molecular weight:577.68

    Ref: TM-T64085

  • GGTI-286 hydrochloride
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    GGTI-286 hydrochloride

    CAS:
    <p>GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).</p>
    Formula:C23H32ClN3O3S
    Color and Shape:Solid
    Molecular weight:466.04

    Ref: TM-T62980

  • SMAP-2
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    SMAP-2

    CAS:
    <p>SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.</p>
    Formula:C27H27F3N2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.57

    Ref: TM-T12934

  • HPK1-IN-26
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    HPK1-IN-26

    CAS:
    <p>HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.</p>
    Formula:C19H21N5OS
    Color and Shape:Solid
    Molecular weight:367.47

    Ref: TM-T61437

  • ZINC09659342
    Targetmol
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    ZINC09659342

    CAS:
    <p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>
    Formula:C23H15F3N2O4
    Color and Shape:Solid
    Molecular weight:440.37

    Ref: TM-T62535

  • NSC-658497
    Targetmol
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    NSC-658497

    CAS:
    <p>NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.</p>
    Formula:C20H10N2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.43

    Ref: TM-T24554

  • SR 3576
    Targetmol
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    SR 3576

    CAS:
    <p>JNK3 inhibitor, potent and selective</p>
    Formula:C27H27N5O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:501.53

    Ref: TM-T23392

  • CAY10561
    Targetmol
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    CAY10561

    CAS:
    <p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>
    Formula:C22H17Cl2FN4O2
    Color and Shape:Solid
    Molecular weight:459.3

    Ref: TM-T36672

  • KRAS G12C inhibitor 22
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    KRAS G12C inhibitor 22

    CAS:
    <p>KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.</p>
    Formula:C32H41N7O2
    Color and Shape:Solid
    Molecular weight:555.71

    Ref: TM-T63926

  • Quazinone
    Targetmol
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    Quazinone

    CAS:
    <p>Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.</p>
    Formula:C11H10ClN3O
    Color and Shape:Solid
    Molecular weight:235.67

    Ref: TM-T36547

  • SB-747651A
    Targetmol
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    SB-747651A

    CAS:
    <p>SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.</p>
    Formula:C16H22N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.4

    Ref: TM-T28695

  • EO 1428
    Targetmol
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    EO 1428

    CAS:
    <p>p38α and p38β2 inhibitor</p>
    Formula:C20H16BrClN2O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.71

    Ref: TM-T22765

  • PD 334581
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    PD 334581

    CAS:
    <p>MEK1 inhibitor</p>
    Formula:C20H19F3IN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:545.3

    Ref: TM-T23129

  • p38α inhibitor 2
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    p38α inhibitor 2

    CAS:
    <p>P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.</p>
    Formula:C27H33N5O3
    Color and Shape:Solid
    Molecular weight:475.58

    Ref: TM-T36012

  • pan-KRAS-IN-16
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    pan-KRAS-IN-16

    CAS:
    <p>3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>
    Formula:C24H26N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:390.47

    Ref: TM-T9184

  • B-Raf IN 6
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    B-Raf IN 6

    CAS:
    <p>B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.</p>
    Formula:C24H21F3N6O2S2
    Color and Shape:Solid
    Molecular weight:546.59

    Ref: TM-T63855

  • (R)-CE3F4
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    (R)-CE3F4

    CAS:
    <p>(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),</p>
    Formula:C11H10Br2FNO
    Color and Shape:Solid
    Molecular weight:351.01

    Ref: TM-T12616

  • SR-3737
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    SR-3737

    CAS:
    <p>SR-3737 is potent both JNK3 and p38 inhibitor.</p>
    Formula:C29H25FN4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:512.53

    Ref: TM-T24829

  • TOPK-p38/JNK-IN-1
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    TOPK-p38/JNK-IN-1

    CAS:
    <p>TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO</p>
    Formula:C17H15F3N2O4
    Color and Shape:Solid
    Molecular weight:368.31

    Ref: TM-T61440

  • B-Raf IN 7
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    B-Raf IN 7

    CAS:
    <p>"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."</p>
    Formula:C15H16N6O3
    Color and Shape:Solid
    Molecular weight:328.33

    Ref: TM-T60933

  • KB-5246
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    KB-5246

    CAS:
    <p>KB-5246, displays antibacterial activities.is a tetracyclic quinolone.</p>
    Formula:C18H17ClFN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:425.86

    Ref: TM-T11744

  • KRas G12C inhibitor 4
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    KRas G12C inhibitor 4

    CAS:
    <p>KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.</p>
    Formula:C33H38ClN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:600.15

    Ref: TM-T11779

  • Avutometinib potassium
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    Avutometinib potassium

    CAS:
    <p>Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.</p>
    Formula:C21H17FKN5O5S
    Color and Shape:Solid
    Molecular weight:509.55

    Ref: TM-T68270

  • 3,4-Dephostatin
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    3,4-Dephostatin

    CAS:
    <p>3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.</p>
    Formula:C7H8N2O3
    Color and Shape:Solid
    Molecular weight:168.15

    Ref: TM-T70232

  • ERK5-IN-3
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    ERK5-IN-3

    CAS:
    <p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>
    Formula:C24H23Cl2FN4O2
    Color and Shape:Solid
    Molecular weight:489.37

    Ref: TM-T63268

  • Ras modulator-1
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    Ras modulator-1

    CAS:
    <p>Ras modulator-1 is a modulator of Ras.</p>
    Formula:C29H21N5O4S
    Color and Shape:Solid
    Molecular weight:535.57

    Ref: TM-T72774

  • KRas G12C inhibitor 3
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    KRas G12C inhibitor 3

    CAS:
    <p>KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.</p>
    Formula:C32H36ClN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:586.13

    Ref: TM-T11778

  • MW108
    Targetmol
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    MW108

    CAS:
    <p>MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.</p>
    Formula:C21H19ClN4
    Color and Shape:Solid
    Molecular weight:362.86

    Ref: TM-T24510

  • (S)-CCG-1423
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    (S)-CCG-1423

    <p>(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A &amp; serum response signaling.</p>
    Formula:C18H13ClF6N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.8

    Ref: TM-T23296

  • K-Ras G12C-IN-3
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    K-Ras G12C-IN-3

    CAS:
    <p>K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.</p>
    Formula:C21H19Cl3N2O3
    Color and Shape:Solid
    Molecular weight:453.75

    Ref: TM-T11737

  • ML 3403
    Targetmol
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    ML 3403

    CAS:
    <p>p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β &amp; TNF-α release in PBMC assay; IC50: 0.039μM &amp; 0.16μM.</p>
    Formula:C23H21FN4S
    Color and Shape:Solid
    Molecular weight:404.5

    Ref: TM-T37590