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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • KRAS G12C inhibitor 45
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    KRAS G12C inhibitor 45

    CAS:
    <p>KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .</p>
    Formula:C32H33F2N5O5S
    Color and Shape:Solid
    Molecular weight:637.7

    Ref: TM-T72336

  • JNK3 inhibitor-4
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    JNK3 inhibitor-4

    CAS:
    <p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>
    Formula:C28H27N7O
    Color and Shape:Solid
    Molecular weight:477.56

    Ref: TM-T72715

  • HPK1-IN-17
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    HPK1-IN-17

    CAS:
    <p>HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.</p>
    Formula:C26H28N6O
    Color and Shape:Solid
    Molecular weight:440.54

    Ref: TM-T62547

  • KRAS inhibitor-17
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    KRAS inhibitor-17

    CAS:
    <p>KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.</p>
    Formula:C21H18Cl2FN3O2S
    Color and Shape:Solid
    Molecular weight:466.36

    Ref: TM-T62981

  • BRAF V600E/CRAF-IN-2
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    BRAF V600E/CRAF-IN-2

    CAS:
    <p>Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.</p>
    Formula:C30H30F3N5O2
    Color and Shape:Solid
    Molecular weight:549.59

    Ref: TM-T63882

  • KRAS4b-PDEδ stabilizer C19
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    KRAS4b-PDEδ stabilizer C19

    CAS:
    <p>KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via</p>
    Formula:C18H20Cl2N2O3
    Color and Shape:Solid
    Molecular weight:383.27

    Ref: TM-T32419

  • SCH 51344
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    SCH 51344

    CAS:
    <p>SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].</p>
    Formula:C16H20N4O3
    Color and Shape:Solid
    Molecular weight:316.36

    Ref: TM-T21676

  • LX-3
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    LX-3

    CAS:
    <p>LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.</p>
    Formula:C20H13BrN4OS
    Color and Shape:Solid
    Molecular weight:437.31

    Ref: TM-T69321

  • KRAS G12C inhibitor 47
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    KRAS G12C inhibitor 47

    CAS:
    <p>KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.</p>
    Formula:C30H28ClFN4O3
    Color and Shape:Solid
    Molecular weight:547.02

    Ref: TM-T63863

  • SOS1-IN-3
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    SOS1-IN-3

    CAS:
    <p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>
    Formula:C21H21F3N4O
    Color and Shape:Solid
    Molecular weight:402.41

    Ref: TM-T61963

  • SOS1 activator 1
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    SOS1 activator 1

    CAS:
    <p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>
    Formula:C26H32ClFN6
    Color and Shape:Solid
    Molecular weight:483.02

    Ref: TM-T63201

  • 6-T-GDP
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    6-T-GDP

    CAS:
    <p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>
    Formula:C10H15N5O10P2S
    Color and Shape:Solid
    Molecular weight:459.27

    Ref: TM-T88704

  • GDC-0879
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    GDC-0879

    CAS:
    <p>GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.</p>
    Formula:C19H18N4O2
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T6320

  • Tpl2-IN-I
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    Tpl2-IN-I

    CAS:
    <p>Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.</p>
    Formula:C21H14ClFN6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.83

    Ref: TM-T26284

  • NSC1011
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    NSC1011

    CAS:
    <p>NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).</p>
    Formula:C23H18N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:370.4

    Ref: TM-T28201

  • AZD6703 free base
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    AZD6703 free base

    CAS:
    <p>AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).</p>
    Formula:C24H27N5O2
    Color and Shape:Solid
    Molecular weight:417.5

    Ref: TM-T26721

  • Kobe2601
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    Kobe2601

    CAS:
    <p>Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.</p>
    Formula:C13H10FN5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:351.31

    Ref: TM-T24267

  • GSK329
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    GSK329

    CAS:
    <p>GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.</p>
    Formula:C19H14Cl2F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:472.25

    Ref: TM-T24109

  • HCI-2184
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    HCI-2184

    CAS:
    <p>HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.</p>
    Formula:C23H28ClN7O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:502.03

    Ref: TM-T24130

  • GSK649A
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    GSK649A

    CAS:
    <p>GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.</p>
    Formula:C15H12ClFN6OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.81

    Ref: TM-T27486

  • CP-281384
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    CP-281384

    CAS:
    <p>CP-281384 is a potent, p38alpha-selective inhibitor.</p>
    Formula:C18H14F2N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:340.33

    Ref: TM-T27062

  • RBC6
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    RBC6

    CAS:
    <p>RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.</p>
    Formula:C16H14Cl2N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:365.21

    Ref: TM-T24707

  • CP-944629
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    CP-944629

    CAS:
    <p>CP-944629 is a novel, potent, and selective inhibitor of p38alpha.</p>
    Formula:C19H15F3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.34

    Ref: TM-T27067

  • BNC-1
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    BNC-1

    CAS:
    <p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>
    Formula:C16H14N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:282.29

    Ref: TM-T26879

  • BSJ-04-122
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    BSJ-04-122

    CAS:
    <p>BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM &amp; 181 nM, used in cancer research.</p>
    Formula:C15H12ClN5O
    Purity:97.61%
    Color and Shape:Solid
    Molecular weight:313.74

    Ref: TM-T73182

  • CK1-IN-2
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    CK1-IN-2

    CAS:
    <p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>
    Formula:C17H12FN3O2
    Purity:99.31%
    Color and Shape:Solid
    Molecular weight:309.29

    Ref: TM-T79145

  • SR-3306
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    SR-3306

    CAS:
    <p>SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values ​​of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.</p>
    Formula:C28H26N8O
    Purity:99.38% - 99.71%
    Color and Shape:Solid
    Molecular weight:490.56

    Ref: TM-T16927

  • GNE-1858
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    GNE-1858

    CAS:
    <p>GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).</p>
    Formula:C21H26F2N8
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:428.48

    Ref: TM-T11438

  • J30-8
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    J30-8

    CAS:
    <p>J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>
    Formula:C17H9ClFN3O2S
    Purity:99.90%
    Color and Shape:Solid
    Molecular weight:373.79

    Ref: TM-T11702

  • TAK1/MAP4K2 inhibitor 1
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    TAK1/MAP4K2 inhibitor 1

    CAS:
    <p>TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.</p>
    Formula:C29H31F3N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:552.59

    Ref: TM-T10444

  • RMM-46
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    RMM-46

    CAS:
    <p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>
    Formula:C24H26N4O5
    Purity:98.89%
    Color and Shape:Solid
    Molecular weight:450.49

    Ref: TM-T26103

  • LY-2584702 hydrochloride
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    LY-2584702 hydrochloride

    CAS:
    <p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>
    Formula:C21H20ClF4N7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.88

    Ref: TM-T11900

  • MEK inhibitor
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    MEK inhibitor

    CAS:
    <p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>
    Formula:C26H26N4O2
    Purity:97.48%
    Color and Shape:Solid
    Molecular weight:426.51

    Ref: TM-T11993

  • NSC-70220
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    NSC-70220

    CAS:
    <p>SOS1-IN-1 is an inhibitor of SOS1.</p>
    Formula:C22H15NO2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:325.36

    Ref: TM-T12978

  • MNK1/2-IN-5
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    MNK1/2-IN-5

    CAS:
    <p>MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.</p>
    Formula:C17H16N4O2
    Purity:98.04%
    Color and Shape:Solid
    Molecular weight:308.33

    Ref: TM-T60733

  • MEK-IN-4
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    MEK-IN-4

    CAS:
    <p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>
    Formula:C21H18N4OS
    Purity:98.35% - 99.16%
    Color and Shape:Solid
    Molecular weight:374.46

    Ref: TM-T28012

  • Nek2-IN-5
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    Nek2-IN-5

    CAS:
    <p>Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).</p>
    Formula:C15H12N6O
    Purity:98.11%
    Color and Shape:Solid
    Molecular weight:292.3

    Ref: TM-T28141

  • mSIRK
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    mSIRK

    CAS:
    <p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>
    Formula:C93H150N20O25
    Purity:99.26%
    Color and Shape:Solid
    Molecular weight:1948.31

    Ref: TM-T80548

  • UR13870
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    UR13870

    CAS:
    <p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>
    Formula:C24H16F2N4
    Purity:99.18% - >99.99%
    Color and Shape:Solid
    Molecular weight:398.41

    Ref: TM-T29071

  • ZINC12409120
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    ZINC12409120

    CAS:
    <p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>
    Formula:C20H16N4O2
    Purity:99.71% - 99.95%
    Color and Shape:Solid
    Molecular weight:344.37

    Ref: TM-T61122

  • p38α inhibitor 4
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    p38α inhibitor 4

    CAS:
    <p>p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.</p>
    Formula:C14H7F6N3O
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:347.215

    Ref: TM-T78652

  • NMDAR/TRPM4-IN-2
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    NMDAR/TRPM4-IN-2

    CAS:
    <p>Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.</p>
    Formula:C11H19BrCl2N2
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:330.092

    Ref: TM-T72662

  • (E)-GABAB receptor antagonist 1
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    (E)-GABAB receptor antagonist 1

    CAS:
    <p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>
    Formula:C18H24O4
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:304.38

    Ref: TM-T11137

  • RMC-0331
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    RMC-0331

    CAS:
    <p>RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.</p>
    Formula:C22H25ClF3N5O3
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:499.91

    Ref: TM-T38170

  • EO-1606
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    EO-1606

    CAS:
    <p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>
    Formula:C21H17ClFNO
    Purity:98.28% - 98.84%
    Color and Shape:Solid
    Molecular weight:353.82

    Ref: TM-T31645

  • p38 MAPK Inhibitor
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    p38 MAPK Inhibitor

    CAS:
    <p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>
    Formula:C20H13ClFN3O
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:365.79

    Ref: TM-T36010

  • DS12881479
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    DS12881479

    CAS:
    <p>DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].</p>
    Formula:C16H19N3OS
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:301.41

    Ref: TM-T60681

  • MKK7-COV-9
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    MKK7-COV-9

    CAS:
    <p>MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.</p>
    Formula:C18H16N4O2
    Purity:99.07% - 99.73%
    Color and Shape:Solid
    Molecular weight:320.35

    Ref: TM-T60857

  • BI-2852
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    BI-2852

    CAS:
    <p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>
    Formula:C31H28N6O2
    Purity:98.98%
    Color and Shape:Solid
    Molecular weight:516.59

    Ref: TM-T10533

  • AKP-001
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    AKP-001

    CAS:
    <p>AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.</p>
    Formula:C21H13ClF2N4O2
    Purity:99.50% - 99.92%
    Color and Shape:Solid
    Molecular weight:426.8

    Ref: TM-T25015