MEK
MEK is a dual-specificity kinase that plays a central role in the MAPK/ERK signaling pathway by activating ERK through phosphorylation. MEK signaling is crucial for regulating cell growth, survival, and differentiation. Aberrant MEK activity has been implicated in various cancers and developmental disorders, making it an important therapeutic target. At CymitQuimica, we provide a variety of MEK inhibitors and modulators to support your research in oncology, cell signaling, and therapeutic development.
Found 75 products for "MEK".
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Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formula:C14H23ClN2OPurity:99.83% - 99.92%Color and Shape:SolidMolecular weight:270.798Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurity:99.88% - >99.99%Color and Shape:White SolidMolecular weight:234.34PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purity:99.66%Color and Shape:SolidMolecular weight:476.23Ref: TM-T21980
1mg60.00€5mg131.00€1mL*10mM (DMSO)152.00€10mg178.00€25mg314.00€50mg447.00€100mg622.00€500mg1,224.00€MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Color and Shape:Odour SolidRef: TM-L1400
1mgTo inquire10μL*10mM (DMSO)To inquire20μL*10mM (DMSO)To inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireCobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formula:C21H21F3IN3O2Purity:98%Color and Shape:SolidMolecular weight:531.318MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Color and Shape:SolidMolecular weight:649.4NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formula:C22H18F2N4O5SPurity:98.62% - 98.86%Color and Shape:White SolidMolecular weight:488.46Luvometinib-d
Luvometinib-d is a deuterium-labeled version of Luvometinib, which is a mitogen-activated protein kinase (MEK) inhibitor with antitumor properties.MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formula:C50H65F3IN7O6SPurity:98%Color and Shape:SolidMolecular weight:1076.06U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFormula:C8H10N4S2Purity:98%Color and Shape:SolidMolecular weight:226.32MEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Formula:C13H10FN3O2SColor and Shape:SolidMolecular weight:291.3FDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Color and Shape:LiquidRef: TM-L1610
1mgTo inquire10μL*10mM (DMSO)To inquire20μL*10mM (DMSO)To inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireMidkine Protein, Human, Recombinant (His & Avi), Biotinylated
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asColor and Shape:Lyophilized PowderMolecular weight:16.46 kDa (predicted) same as Tris-Bis PAGE result.Ref: TM-TMPK-00024
5µg94.00€10µg138.00€20µg220.00€50µg434.00€100µg732.00€200µg1,324.00€500µg2,925.00€Anti-Midkine Antibody (5T766)
Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.Color and Shape:Odour LiquidMidkine Protein, Mouse, Recombinant (His)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPurity:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCColor and Shape:Transparent SolutionMolecular weight:14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPurity:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGEColor and Shape:White Lyophilized PowderMolecular weight:16.46 kDa (predicted) same as Tris-Bis PAGE result.RO4987655
CAS:RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).Formula:C20H19F3IN3O5Purity:98.21%Color and Shape:White SolidMolecular weight:565.28CI-1040
CAS:CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).Formula:C17H14ClF2IN2O2Purity:99.64%Color and Shape:White SolidMolecular weight:478.66zapnometinib
CAS:Zapnometinib (ATR-002) is a MEK inhibitor.Formula:C13H7ClF2INO2Purity:99.67%Color and Shape:SolidMolecular weight:409.55Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurity:98.3% - 98.81%Color and Shape:White SolidMolecular weight:471.46Ref: TM-T6971
1mg54.00€2mg78.00€5mg109.00€1mL*10mM (DMSO)112.00€10mg169.00€25mg311.00€50mg500.00€100mg718.00€anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormula:C45H74O18Purity:99.06% - 99.11%Color and Shape:SolidMolecular weight:903.06BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purity:97.84%Color and Shape:SolidMolecular weight:440.54Ref: TM-T21295
2mg33.00€5mg52.00€1mL*10mM (DMSO)55.00€10mg71.00€25mg119.00€50mg198.00€100mg296.00€200mg427.00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purity:98.63% - >99.99%Color and Shape:Green SolidMolecular weight:267.28Ref: TM-T2623
5mg38.00€1mL*10mM (DMSO)39.00€10mg50.00€25mg78.00€50mg101.00€100mg168.00€200mg250.00€500mg421.00€Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C15H15FIN3O3Purity:98.25% - 99.57%Color and Shape:SolidMolecular weight:431.2Ref: TM-T6131
2mg34.00€5mg50.00€1mL*10mM (DMSO)52.00€10mg58.00€25mg96.00€50mg140.00€100mg207.00€200mg270.00€Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Formula:C19H20F3IN2O5SPurity:99.85% - >99.99%Color and Shape:SolidMolecular weight:572.34Ref: TM-T6636
2mg43.00€5mg63.00€1mL*10mM (DMSO)79.00€10mg93.00€25mg147.00€50mg222.00€100mg326.00€200mg485.00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrClFN4O3Purity:98.1% - 99.90%Color and Shape:White SolidMolecular weight:457.68TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C17H15F2IN4O4Purity:98.31% - 99.2%Color and Shape:White SolidMolecular weight:504.23APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Formula:C23H21N3O3Color and Shape:SolidMolecular weight:387.43Trametinib (DMSO solvate)
CAS:Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)Formula:C28H29FIN5O5SPurity:99.71% - 99.92%Color and Shape:SolidMolecular weight:693.53Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purity:98.03% - >99.99%Color and Shape:SolidMolecular weight:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purity:99.73%Color and Shape:SolidMolecular weight:408.87Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purity:99.11% - 99.63%Color and Shape:White SolidMolecular weight:482.19Ref: TM-T6189
5mg49.00€1mL*10mM (DMSO)52.00€10mg71.00€25mg120.00€50mg172.00€100mg259.00€200mg385.00€500mg627.00€1g850.00€GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Formula:C16H14FIN4O3Purity:98.95% - 99.02%Color and Shape:SolidMolecular weight:456.21Ref: TM-T6843
1mg50.00€2mg70.00€5mg113.00€1mL*10mM (DMSO)113.00€10mg177.00€25mg265.00€50mg349.00€100mg580.00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purity:98.72% - 99.91%Color and Shape:SolidMolecular weight:461.23Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formula:C4H3AuNa2O4SPurity:99.66%Color and Shape:SolidMolecular weight:390.07Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Formula:C15H16ClFIN3O3Color and Shape:SolidMolecular weight:467.66SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Formula:C16H12F3N3SPurity:97.98% - >99.99%Color and Shape:SolidMolecular weight:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Formula:C17H13BrClF2IN2O2Purity:99.40%Color and Shape:SolidMolecular weight:557.56Ref: TM-T21635
1mg35.00€2mg49.00€5mg74.00€10mg119.00€25mg259.00€50mg430.00€100mg620.00€200mg888.00€500mg1,333.00€BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purity:97.13% - 97.54%Color and Shape:Yellow SolidMolecular weight:464.56U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Formula:C18H16N6S2·C2H6OPurity:99.72% - 99.88%Color and Shape:SolidMolecular weight:426.6trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurity:97.13% - 98.96%Color and Shape:White SolidMolecular weight:219.24Ref: TM-TMS2181
1mL*10mM (DMSO)33.00€10mg37.00€25mg52.00€50mg66.00€100mg96.00€200mg128.00€500mg205.00€Cobimetinib
CAS:Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C21H21F3IN3O2Purity:98% - 99.96%Color and Shape:White SolidMolecular weight:531.31Ref: TM-T3623
500mgTo inquire1mg38.00€2mg49.00€5mg80.00€10mg90.00€1mL*10mM (DMSO)94.00€25mg170.00€50mg261.00€100mg429.00€U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Formula:C18H16N6S2Purity:99.61%Color and Shape:White SolidMolecular weight:380.49APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Formula:C23H21N3O3·HClPurity:98.64% - 99.55%Color and Shape:SolidMolecular weight:423.89Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Formula:C16H12O7Purity:99.20% - >99.99%Color and Shape:Yellow SolidMolecular weight:316.26Ref: TM-T2836
1mg38.00€2mg49.00€5mg78.00€1mL*10mM (DMSO)81.00€10mg113.00€25mg222.00€50mg371.00€100mg532.00€PD318088
CAS:PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-Formula:C16H13BrF3IN2O4Purity:99.60%Color and Shape:White SolidMolecular weight:561.09Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purity:98% - 99.96%Color and Shape:SolidMolecular weight:615.39GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Formula:C23H20N2O3Purity:99.75%Color and Shape:SolidMolecular weight:372.42
