Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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Yck2-IN-1
CAS:<p>Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.</p>Formula:C19H11FN4Color and Shape:SolidMolecular weight:314.316LDHA-IN-5
CAS:<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Formula:C27H22FN7O6S3Color and Shape:SolidMolecular weight:655.7BMS-185354
CAS:<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Formula:C26H27NO3Color and Shape:SolidMolecular weight:401.497NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Formula:C18H25N3OS2Color and Shape:SolidMolecular weight:363.54Lp-PLA2-IN-6
CAS:<p>Lp-PLA2-IN-6: Potent tetracyclic inhibitor of rhLp-PLA2, with pIC50 of 10.0, and potential in neurodegenerative research.</p>Formula:C25H21F5N4O3Color and Shape:SolidMolecular weight:520.45NSC 828467
<p>NSC 828467 is one of the top five CA-IX inhibitors with significant in vitro anticancer activity (IC50: 27.2 nM).</p>Formula:C21H19N9O2SColor and Shape:SolidMolecular weight:461.5GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Formula:C26H30N2O7Color and Shape:SolidMolecular weight:469.01E234G HYPE-IN-1
CAS:<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Formula:C14H9N5O2Color and Shape:SolidMolecular weight:279.252-Amino-5-methyl-5-hexenoic acid
CAS:<p>2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.</p>Formula:C7H13NO2Color and Shape:SolidMolecular weight:143.184Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Formula:C26H22F3N7OSColor and Shape:SolidMolecular weight:537.56RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Formula:C29H35F3N2O3Color and Shape:SolidMolecular weight:516.6Glucosylceramide synthase-IN-4
CAS:<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Formula:C22H18F5N3O3Color and Shape:SolidMolecular weight:467.39(E)-10-Hydroxynortriptyline maleate
CAS:<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.455IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.88AD012
<p>AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.</p>Formula:C25H32N2O6Color and Shape:SolidMolecular weight:456.53Rosiptor acetate
CAS:<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Formula:C22H39NO4Purity:98%Color and Shape:Solid PowderMolecular weight:381.55BLT-4
CAS:<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Formula:C18H16N2O2Color and Shape:SolidMolecular weight:292.332α-Amylase-IN-10
CAS:<p>α-Amylase-IN-10 (Compound 15n) is an inhibitor of α-Amylase, with an IC50 of 5.00 µM. This compound is applicable for research in type 2 diabetes.</p>Formula:C21H15ClN2O4SColor and Shape:SolidMolecular weight:426.873Calcipotriol Impurity C
CAS:<p>Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.</p>Formula:C27H40O3Purity:98%Color and Shape:SolidMolecular weight:412.614LXRβ agonist-3
CAS:<p>LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).</p>Formula:C30H33N3O6SColor and Shape:SolidMolecular weight:563.66SGK1-IN-3
<p>SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.</p>Formula:C23H20Cl2N6O3SColor and Shape:SolidMolecular weight:531.41LXRα agonist 1
CAS:<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Formula:C28H27N3O2Color and Shape:SolidMolecular weight:437.533α-Amylase/α-Glucosidase-IN-7
CAS:<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Formula:C15H9Cl2FN2OSColor and Shape:SolidMolecular weight:355.21ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Formula:C20H34O5Color and Shape:SolidMolecular weight:354.48DS44470011
CAS:<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formula:C21H19N3O4Color and Shape:SolidMolecular weight:377.39Enpp-1-IN-7
<p>Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)</p>Formula:C18H19N7O4SColor and Shape:SolidMolecular weight:429.45Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Formula:C24H20ClN3O3SColor and Shape:SolidMolecular weight:465.95TMX-4116
CAS:<p>TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.</p>Formula:C17H19N5O4SColor and Shape:SolidMolecular weight:389.43Vimirogant
CAS:<p>Vimirogant is a RORγ inhibitor (Ki: <100 nM).</p>Formula:C27H35F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:552.65Enpp-1-IN-11
<p>Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.</p>Formula:C15H15N5O3SColor and Shape:SolidMolecular weight:345.38PKM2-IN-9
CAS:<p>PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.</p>Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.457RORγt inverse agonist 29
<p>RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.</p>Formula:C25H24N2O5SColor and Shape:SolidMolecular weight:464.53Mucidin
CAS:<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Formula:C16H18O3Molecular weight:258.31Mitapivat hydrochloride
CAS:<p>Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.</p>Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014hCA VB-IN-1
<p>hCA VB-IN-1 (compound 15) is a potent and selective inhibitor of hCA VB (carbonic anhydrase) with a KI of 515.7 nM [1].</p>Formula:C9H13N3O4SColor and Shape:SolidMolecular weight:259.28FABP1-IN-1
CAS:<p>FABP1-IN-1 (44) is a selective FABP1 inhibitor with an IC50 value of 4.46 μM. It is applicable in research related to alcoholic fatty liver disease.</p>Formula:C30H25NO5Molecular weight:479.52ROR1-IN-1
CAS:<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Formula:C33H27N5O3Molecular weight:541.60BMS-986339
CAS:<p>BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.</p>Formula:C35H41F4N3O4Color and Shape:SolidMolecular weight:643.71hCAII-IN-5
CAS:<p>hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1].</p>Formula:C29H18N2O7Color and Shape:SolidMolecular weight:506.46Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Formula:C28H30N4O2Color and Shape:SolidMolecular weight:454.56Nomelidine
CAS:<p>Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.</p>Formula:C15H15BrN2Purity:98%Color and Shape:SolidMolecular weight:303.20sEH inhibitor-2
<p>SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.</p>Formula:C23H18N4O3Color and Shape:SolidMolecular weight:398.41Carbonic anhydrase inhibitor 10
<p>CA inhibitor 10 targets MCF-7 cells, IC50: 11.9 μM; potent h CA IX inhibitor, Ki: 6.2 nM. Anti-cancer research.</p>Formula:C14H17N5O3SColor and Shape:SolidMolecular weight:335.38BRD7539
CAS:<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Formula:C23H22FN3O2Purity:98%Color and Shape:SolidMolecular weight:391.44PNPLA3 modifier 1
CAS:<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>Formula:C16H19ClF2N2O4SColor and Shape:SolidMolecular weight:408.85Deamino-NAD sodium
CAS:<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Formula:C21H25N6NaO15P2Color and Shape:SolidMolecular weight:686.39α-Glucosidase-IN-14
<p>α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase (IC50: 5.22 μM).</p>Formula:C24H27N5O4S2Color and Shape:SolidMolecular weight:513.63Pyrocatechol sulfate
CAS:<p>Pyrocatechol sulfate, a phenolic metabolite found in human plasma, is associated with the intake of specific foods such as berries and the state of the gut microbiome. It serves as a potential urinary biomarker for kidney function, dialysis clearance rates, whole grain consumption, and regular coffee intake. Additionally, in conjunction with other phenolic sulfates, pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiac cells.</p>Formula:C6H6O5SColor and Shape:SolidMolecular weight:190.17D-2-Phosphoglyceric acid
CAS:<p>D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.</p>Formula:C3H7O7PColor and Shape:SolidMolecular weight:186.06Lp-PLA2-IN-5
CAS:<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Formula:C23H18F5N3O4Color and Shape:SolidMolecular weight:495.4
