Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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LU 2443
CAS:<p>LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.</p>Formula:C9H8N2S2Color and Shape:SolidMolecular weight:208.3LXRα agonist 1
CAS:<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Formula:C28H27N3O2Color and Shape:SolidMolecular weight:437.533Imipramine Blue chloride
<p>Imipramine Blue chloride is an effective anti-invasive agent capable of inhibiting glioma invasion. It suppresses the production of reactive oxygen species (reactive oxygen species) mediated by NADPH oxidase.</p>Formula:C40H51ClN4Color and Shape:SolidMolecular weight:623.317PPD-Q
CAS:<p>7PPD-Q is a substituted p-phenylenediamine antioxidant derivative. It exhibits toxicity towards the bacterium V. fischeri (EC50= 14.9 mg/L).</p>Formula:C19H24N2O2Color and Shape:SolidMolecular weight:312.41Diacylglycerol acyltransferase inhibitor-1
CAS:<p>Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.</p>Formula:C21H23N5O2Purity:98%Color and Shape:SolidMolecular weight:377.44α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Formula:C25H28N4O3S2Color and Shape:SolidMolecular weight:496.64Emopamil
CAS:<p>Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.</p>Formula:C23H30N2Color and Shape:SolidMolecular weight:334.5KY-455
CAS:<p>KY-455 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. It demonstrates inhibition of ACAT in rabbit intestines, liver, macrophages, and adrenal glands with IC50 values of 0.4, 0.9, 2.9, and 4.1 μmol/L, respectively.</p>Formula:C20H32N2OColor and Shape:SolidMolecular weight:316.487-hydroxychlorpromazine
CAS:<p>7-Hydroxychlorpromazine, an active metabolite of Chlorpromazine, can reversibly counteract the suppression of regionally dense dopaminergic neurons induced by Amphetamine.</p>Formula:C17H19ClN2OSColor and Shape:SolidMolecular weight:334.86CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Formula:C27H27F9N2O4Color and Shape:SolidMolecular weight:614.5α-Amylase/α-Glucosidase-IN-7
CAS:<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Formula:C15H9Cl2FN2OSColor and Shape:SolidMolecular weight:355.21MAGL-IN-19
CAS:<p>MAGL-IN-19 (compound 7o) is a highly effective and selective inhibitor of MAGL.</p>Formula:C21H26F3N3O3Color and Shape:SolidMolecular weight:425.45FTI 276 TFA
CAS:<p>FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).</p>Formula:C23H28F3N3O5S2Color and Shape:SolidMolecular weight:547.61hCAII-IN-4
CAS:<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Formula:C31H23NO9Color and Shape:SolidMolecular weight:553.52Retezorogant
CAS:<p>Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.</p>Formula:C23H33ClN2O3Color and Shape:SolidMolecular weight:420.97Carbonic anhydrase inhibitor 17
CAS:<p>Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.</p>Formula:C18H15ClN4O3S2Molecular weight:434.92α-Amylase-IN-10
CAS:<p>α-Amylase-IN-10 (Compound 15n) is an inhibitor of α-Amylase, with an IC50 of 5.00 µM. This compound is applicable for research in type 2 diabetes.</p>Formula:C21H15ClN2O4SColor and Shape:SolidMolecular weight:426.873Turoctocog alfa
CAS:<p>Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.</p>Color and Shape:SolidPDE4-IN-14
CAS:<p>PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including</p>Formula:C19H20F2N4O3SColor and Shape:SolidMolecular weight:422.45trans-Doxercalciferol
CAS:<p>trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.</p>Formula:C28H44O2Purity:98%Color and Shape:SolidMolecular weight:412.65IDO1-IN-13
<p>IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.</p>Formula:C20H16BrN5O2SColor and Shape:SolidMolecular weight:470.34Fusarisetin A
CAS:<p>Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .</p>Formula:C22H31NO5Color and Shape:SolidMolecular weight:389.49(Rac)-OSMI-1
<p>(Rac)-OSMI-1, a racemate, inhibits OGT (IC50: 2.7 μM) affecting O-GlcNAcylation without changing surface glycans.</p>Formula:C28H25N3O6S2Color and Shape:SolidMolecular weight:563.64Thioquinapiperifil dihydrochloride
CAS:<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Formula:C24H29ClN6OSPurity:98.73%Color and Shape:SolidMolecular weight:485.05hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Formula:C17H21N3O3SColor and Shape:SolidMolecular weight:347.43Lipoxin A5
CAS:<p>LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.</p>Formula:C20H30O5Color and Shape:SolidMolecular weight:350.45RORγ-IN-2
CAS:<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Formula:C28H32F3N5O4S2Color and Shape:SolidMolecular weight:623.71GSK 366
CAS:<p>GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).</p>Formula:C17H16ClN3O4Purity:98%Color and Shape:SolidMolecular weight:361.78Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Formula:C27H31F3N4O5SColor and Shape:SolidMolecular weight:580.627-Hydroxyrisperidone
CAS:<p>7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.</p>Formula:C23H27FN4O3Color and Shape:SolidMolecular weight:426.484APOL1-IN-3
CAS:<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Formula:C16H19F3N4O2SColor and Shape:SolidMolecular weight:388.41DX-9065A HCl hydrate
CAS:<p>DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.</p>Formula:C26H39ClN4O8Purity:98%Color and Shape:SolidMolecular weight:571.06HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Formula:C16H12N2O3Color and Shape:SolidMolecular weight:280.282R,4S-Sacubitril
CAS:<p>2R,4S-Sacubitril (Sacubitril Enantiomer) is the impurity of Sacubitril which is a neprilysin inhibitor.</p>Formula:C24H28NO51CaPurity:98%Color and Shape:SolidMolecular weight:430.49NNC 55-0396
CAS:<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Formula:C30H40Cl2FN3O2Purity:99.00%Color and Shape:SolidMolecular weight:564.56Complex III-IN-1
<p>Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.</p>Formula:C14H20ClNO2S2Color and Shape:SolidMolecular weight:333.9Cilazaprilat
CAS:<p>Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.</p>Formula:C20H27N3O5Color and Shape:SolidMolecular weight:389.45PDE5-IN-8
CAS:<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formula:C22H20ClN3O2Color and Shape:SolidMolecular weight:393.87GSK864
CAS:<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Formula:C30H31FN6O4Purity:97.07%Color and Shape:SolidMolecular weight:558.6FXIa-IN-6
CAS:<p>FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.</p>Formula:C31H29ClF2N4O4Color and Shape:SolidMolecular weight:595.04CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Formula:C26H22BrN5O2Purity:99.04%Color and Shape:SolidMolecular weight:516.39Vimirogant hydrochloride
<p>Vimirogant (VTP-43742) HCl: Oral, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM), >1000x selectivity over RORα/β, targets Th17, not Th1/2/Treg.</p>Formula:C27H36ClF3N4O3SColor and Shape:SolidMolecular weight:588.21487Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Formula:C26H22F3N7OSColor and Shape:SolidMolecular weight:537.56AZD 4407
CAS:<p>AZD 4407 is a potent inhibitor of 5-lipoxygenase.</p>Formula:C19H21NO3S2Purity:98%Color and Shape:SolidMolecular weight:375.5Glucosylceramide synthase-IN-4
CAS:<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Formula:C22H18F5N3O3Color and Shape:SolidMolecular weight:467.39Carbonic anhydrase inhibitor 10
<p>CA inhibitor 10 targets MCF-7 cells, IC50: 11.9 μM; potent h CA IX inhibitor, Ki: 6.2 nM. Anti-cancer research.</p>Formula:C14H17N5O3SColor and Shape:SolidMolecular weight:335.38Tabimorelin hemifumarate
CAS:<p>orally active ghrelin receptor (GHS-R1a) agonist</p>Formula:C32H40N403C4H404Purity:98%Color and Shape:SolidMolecular weight:586.72Rostratin B
CAS:<p>Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.</p>Formula:C18H20N2O6S2Color and Shape:SolidMolecular weight:424.49Inosine 5′-diphosphate sodium
CAS:<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Formula:C10H13N4Na3O12P2Color and Shape:SolidMolecular weight:512.15
