IDO
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan, leading to the production of kynurenine and other metabolites. IDO plays a role in immune tolerance and is often upregulated in cancer and chronic inflammatory conditions. Inhibitors of IDO are being explored as potential immunotherapeutic agents in cancer and autoimmune diseases. At CymitQuimica, we provide IDO inhibitors to support your research in immunology, oncology, and metabolic regulation.
Found 82 products of "IDO"
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LY3381916
CAS:<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>Formula:C23H25FN2O3Purity:99.3%Color and Shape:SolidMolecular weight:396.45IDO-IN-13
CAS:<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>Formula:C26H17F3N4OPurity:99.29%Color and Shape:SolidMolecular weight:458.43GNF-PF-3777
CAS:<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Formula:C15H7N3O4Purity:97.88%Color and Shape:SolidMolecular weight:293.23IDO1-IN-11
CAS:<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Formula:C22H17ClFN3O3Color and Shape:SolidMolecular weight:425.84IDO1-IN-23
<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>Purity:98%Color and Shape:Odour SolidNLG802
CAS:<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Formula:C20H30ClN3O3Purity:99.61%Color and Shape:SolidMolecular weight:395.92human TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Formula:C30H36N4O5Color and Shape:SolidMolecular weight:532.631XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Color and Shape:Odour SolidIDO1/TDO-IN-7
<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>Color and Shape:Odour SolidCAY10581
CAS:<p>CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50</p>Formula:C22H21NO4Color and Shape:SolidMolecular weight:363.41IDO1-IN-24
<p>IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.</p>Formula:C18H22N2O4Molecular weight:330.15796NU223612
CAS:<p>"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."</p>Formula:C49H55FN6O9Color and Shape:SolidMolecular weight:890.99IDO1/TDO-IN-8
<p>IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.</p>Formula:C17H14N2SColor and Shape:SolidMolecular weight:278.37IDO1-IN-12
CAS:<p>IDO1-IN-12 is a potent and orally available IDO1 inhibitor.</p>Formula:C21H19F3N2O2Color and Shape:SolidMolecular weight:388.39PROTAC IDO1 Degrader-1
CAS:<p>First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.</p>Formula:C40H53BrFN9O13Color and Shape:SolidMolecular weight:966.816NU227326
CAS:<p>NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).</p>Formula:C53H61FN8O7Color and Shape:SolidMolecular weight:941.099TDO-IN-2
<p>TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.</p>Formula:C20H15N3O3Color and Shape:SolidMolecular weight:345.11134IDO1-IN-7
CAS:<p>IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.</p>Formula:C22H19ClFN3O3Color and Shape:SolidMolecular weight:427.86IDO-IN-15
CAS:<p>IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).</p>Formula:C29H39N5O4Color and Shape:SolidMolecular weight:521.662BMT-297376
CAS:<p>BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.</p>Formula:C23H29F2N3O3Color and Shape:SolidMolecular weight:433.5IDO1 Protein, Human, Recombinant
<p>IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.</p>Color and Shape:Lyophilized PowderMolecular weight:45.2 kDa (predicted); 46 kDa (reducing conditions)(S)-IDO1-IN-5
CAS:<p>(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 μΜ).</p>Formula:C23H25FN2O3Color and Shape:SolidMolecular weight:396.45IDO1 Protein, Mouse, Recombinant (His)
<p>IDO Protein, Mouse, Recombinant (His) is expressed in E.</p>Purity:≥ 90 % as determined by SDS-PAGE. - ≥ 90 % as determined by SDS-PAGE.Color and Shape:Lyophilized PowderMolecular weight:46.47 kDa (predicted)Anti-IDO1 Antibody (9Y885)
<p>Anti-IDO1 Antibody (9Y885) is an antibody targeting IDO1. Anti-IDO1 Antibody (9Y885) can be used in ELISA, IHC.</p>Color and Shape:Odour LiquidIDO1 Protein, Human, Recombinant (His)
<p>IDO Protein, Human, Recombinant (His) is expressed in E.</p>Color and Shape:Lyophilized PowderMolecular weight:46 kDa (predicted); 44 kDa (reducing conditions)(Rac)-IDO1-IN-5
CAS:<p>(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.</p>Formula:C23H25FN2O3Color and Shape:SolidMolecular weight:396.45IDO1/TDO-IN-4
CAS:<p>IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.</p>Formula:C14H10N4Purity:98.88%Color and Shape:SolidMolecular weight:234.26(S)-Indoximod
CAS:<p>(S)-Indoximod (L-Abrine) is an indoleamine-2,3-dioxygenase (IDO) inhibitor for cancer research.</p>Formula:C12H14N2O2Purity:95.39%Color and Shape:SolidMolecular weight:218.25Navoximod
CAS:<p>Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).</p>Formula:C18H21FN2O2Purity:99.37%Color and Shape:SolidMolecular weight:316.37BMS-986242
CAS:<p>BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.</p>Formula:C24H24ClFN2OPurity:98.9%Color and Shape:SolidMolecular weight:410.91IDO5L
CAS:<p>IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).</p>Formula:C9H7ClFN5O2Purity:99.49% - 99.75%Color and Shape:SolidMolecular weight:271.64PCC0208009
CAS:<p>PCC0208009 (IDO-IN-2) is an IDO inhibitor.</p>Formula:C29H35N7OPurity:99.89%Color and Shape:SolidMolecular weight:497.63Epacadostat
CAS:<p>Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.</p>Formula:C11H13BrFN7O4SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:438.23IDO1-IN-1
CAS:<p>IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.</p>Formula:C7H7N3SPurity:99.36%Color and Shape:Slightly Yellow To Beige-Green Crystalline PowderMolecular weight:165.22Linrodostat mesylate
CAS:<p>Linrodostat (BMS-986205) is an oral IDO1 inhibitor that boosts immune response and has anti-cancer properties.</p>Formula:C25H28ClFN2O4SPurity:98%Color and Shape:SolidMolecular weight:507.02Indoximod
CAS:<p>Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.</p>Formula:C12H14N2O2Purity:97.82% - 99.55%Color and Shape:SolidMolecular weight:218.253-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formula:C7H6N4Purity:99.16% - >99.99%Color and Shape:SolidMolecular weight:146.15PF-06840003
CAS:<p>PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.</p>Formula:C12H9FN2O2Purity:99.10%Color and Shape:SolidMolecular weight:232.21Necrostatin 2 racemate
CAS:<p>Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.</p>Formula:C13H12ClN3O2Purity:98% - 99.5%Color and Shape:SolidMolecular weight:277.71IDO-IN-1
CAS:<p>IDO-IN-1: potent IDO inhibitor, IC50 of 59 nM (enzyme), 12 nM (HeLa cells).</p>Formula:C9H7BrFN5O2Purity:99.91%Color and Shape:SolidMolecular weight:316.09Linrodostat
CAS:<p>Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.</p>Formula:C24H24ClFN2OPurity:99.54% - 99.71%Color and Shape:SolidMolecular weight:410.91IDO-IN-7
CAS:<p>IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.</p>Formula:C18H22N2OPurity:99.32% - 99.9%Color and Shape:SolidMolecular weight:282.38IDO1-IN-21
CAS:<p>IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].</p>Formula:C21H19F2N3O6SPurity:98%Color and Shape:SolidMolecular weight:479.45IDO-IN-5
CAS:<p>IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).</p>Formula:C18H21FN2O2Purity:98%Color and Shape:SolidMolecular weight:316.37IDO1/TDO-IN-3
CAS:<p>IDO1/TDO-IN-3 inhibits IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM) with strong anti-tumor activity and low toxicity.</p>Formula:C16H6ClF2N3O2Color and Shape:SolidMolecular weight:345.69IDO-IN-11
CAS:<p>IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).</p>Formula:C19H23BrFN7O4SPurity:98%Color and Shape:SolidMolecular weight:544.4IACS-8968 R-enantiomer
CAS:<p>IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).</p>Formula:C17H18F3N5O2Purity:98%Color and Shape:SolidMolecular weight:381.35IDO-IN-4
CAS:<p>IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.</p>Formula:C26H35N3O3Color and Shape:SolidMolecular weight:437.57IDO-IN-6
CAS:<p>IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Formula:C18H21FN2O2Purity:98%Color and Shape:SolidMolecular weight:316.37IDO1-IN-18
CAS:<p>IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has potential for cancer disease research.</p>Formula:C23H18F4N2O3Color and Shape:SolidMolecular weight:446.39MMG-0358
CAS:<p>MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.</p>Formula:C8H6ClN3OColor and Shape:SolidMolecular weight:195.61IDO-IN-16
CAS:<p>IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).</p>Formula:C22H21F3N4OColor and Shape:SolidMolecular weight:414.42IDO/TDO-IN-1
CAS:<p>IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).</p>Formula:C25H24FN5Purity:98%Color and Shape:SolidMolecular weight:413.49IDO1/TDO-IN-2
CAS:<p>IDO1/TDO-IN-2: IDO1/TDO inhibitor; IC50s: IDO1, 0.1μM; TDO, 0.07μM; potential for cancer research.</p>Formula:C16H9N3O2Color and Shape:SolidMolecular weight:275.26IDO1-IN-16
CAS:<p>IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM).</p>Formula:C25H35BrFN5O2Color and Shape:SolidMolecular weight:536.48IDO1-IN-15
CAS:<p>IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.</p>Formula:C13H14BrFN6O3Color and Shape:SolidMolecular weight:401.19DP00477
CAS:<p>DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM.</p>Formula:C17H11ClF3N3OSColor and Shape:SolidMolecular weight:397.8IDO1-IN-17
CAS:<p>IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .</p>Formula:C28H32BrClFN5O2Color and Shape:SolidMolecular weight:604.94IDO-IN-14
CAS:<p>IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).</p>Formula:C23H23ClN4O2Color and Shape:SolidMolecular weight:422.91Roxyl-9
CAS:<p>Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].</p>Formula:C18H13N3O2Color and Shape:SolidMolecular weight:303.31IDO-IN-12
CAS:<p>IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).</p>Formula:C13H11BrFN5O3SPurity:99.727%Color and Shape:SolidMolecular weight:416.23IACS-8968 S-enantiomer
CAS:<p>IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).</p>Formula:C17H18F3N5O2Purity:98%Color and Shape:SolidMolecular weight:381.35IACS-8968
CAS:<p>IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).</p>Formula:C17H18F3N5O2Purity:98%Color and Shape:SolidMolecular weight:381.35IDO-IN-8
CAS:<p>IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).</p>Formula:C18H21FN2O2Purity:98%Color and Shape:SolidMolecular weight:316.37IDO1-IN-2
CAS:<p>IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.</p>Formula:C15H17FN6O4Purity:98%Color and Shape:SolidMolecular weight:364.33IDO-IN-3
CAS:<p>IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).</p>Formula:C11H12BrFN6O2Color and Shape:SolidMolecular weight:359.15TDO-IN-1
CAS:<p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>Formula:C16H13F3N4O2Purity:99.86%Color and Shape:SolidMolecular weight:350.3(R)-IDO/TDO-IN-1
CAS:<p>(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].</p>Formula:C25H24FN5Color and Shape:SolidMolecular weight:413.49IDO-IN-9
CAS:<p>IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).</p>Formula:C13H13BrFN7O3SPurity:98%Color and Shape:SolidMolecular weight:446.25NUCC-0223619
CAS:<p>NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.</p>Formula:C24H24ClFN2O2Color and Shape:SolidMolecular weight:426.91IDO1/TDO-IN-6
CAS:<p>IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.</p>Formula:C20H17NO5Purity:98%Color and Shape:SolidMolecular weight:351.35IDO1/2-IN-1
CAS:<p>First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).</p>Formula:C16H18BrFN8O4Color and Shape:SolidMolecular weight:485.271-Isopropyltryptophan
CAS:<p>1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].</p>Formula:C14H18N2O2Purity:98%Color and Shape:SolidMolecular weight:246.3IDO1/2-IN-1 hydrochloride
CAS:<p>IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.</p>Formula:C16H19BrClFN8O4Color and Shape:SolidMolecular weight:521.73IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.88VS-15
CAS:<p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>Formula:C29H27N5O3Color and Shape:SolidMolecular weight:493.56IDO1-IN-14
<p>IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.</p>Formula:C18H12Cl2FN3O2Color and Shape:SolidMolecular weight:392.21IDO1-IN-25
CAS:<p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>Formula:C14H8Cl3NO2SColor and Shape:SolidMolecular weight:360.64IDO1-IN-13
<p>IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.</p>Formula:C20H16BrN5O2SColor and Shape:SolidMolecular weight:470.34IDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Formula:C29H34FN3O2Color and Shape:SolidMolecular weight:475.598IDO2-IN-1
CAS:<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Formula:C21H21BrN10O3Color and Shape:SolidMolecular weight:541.364-Phenyl-1H-1,2,3-triazole
CAS:<p>4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].</p>Formula:C8H7N3Purity:98%Color and Shape:SolidMolecular weight:145.16
