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p97

p97

p97 inhibitors are compounds that inhibit p97, also known as Valosin-Containing Protein (VCP), an ATPase involved in various cellular processes, including protein degradation, cell cycle regulation, and DNA repair. p97 is a key player in the ubiquitin-proteasome system and its inhibition is of interest in cancer research, neurodegenerative diseases, and other disorders where protein homeostasis is disrupted. At CymitQuimica, we offer p97 inhibitors to support your research in proteostasis, neurobiology, and cancer therapy.

Found 14 products of "p97"

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  • CymitQuimica logo
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    NSC819701

    <p>NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.</p>
    Formula:C30H32F2N8O3S
    Color and Shape:Solid
    Molecular weight:622.69

    Ref: TM-T89915

  • UP12
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    UP12

    CAS:
    <p>UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>
    Formula:C23H16ClN3O3S
    Color and Shape:Solid
    Molecular weight:449.91

    Ref: TM-T203349

  • UP158
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    UP158

    CAS:
    <p>UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>
    Formula:C17H17ClN4O2
    Color and Shape:Solid
    Molecular weight:344.8

    Ref: TM-T203467

  • UP163
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    UP163

    CAS:
    <p>UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.</p>
    Formula:C20H15ClN2O5S
    Color and Shape:Solid
    Molecular weight:430.86

    Ref: TM-T203431

  • MSC1094308
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    MSC1094308

    CAS:
    <p>MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.</p>
    Formula:C29H29F3N2
    Color and Shape:Solid
    Molecular weight:462.55

    Ref: TM-T12114

  • CB-5083
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    CB-5083

    CAS:
    <p>CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).</p>
    Formula:C24H23N5O2
    Purity:95.95% - 99.92%
    Color and Shape:Solid
    Molecular weight:413.47

    Ref: TM-T6796

  • ML240
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    ML240

    CAS:
    <p>ML240 is a selective, ATP-competitive p97 inhibitor.</p>
    Formula:C23H20N6O
    Purity:99.73% - >99.99%
    Color and Shape:Solid
    Molecular weight:396.44

    Ref: TM-T3535

  • ML241 hydrochloride
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    ML241 hydrochloride

    CAS:
    <p>ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-</p>
    Formula:C23H25ClN4O
    Purity:99.91% - 99.96%
    Color and Shape:Solid
    Molecular weight:408.92

    Ref: TM-T4684

  • ML241
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    ML241

    CAS:
    <p>ML241 is a potent and selective inhibitors of p97 ATPase.</p>
    Formula:C23H24N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T3164

  • DBEQ
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    DBEQ

    CAS:
    <p>DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.</p>
    Formula:C22H20N4
    Purity:98.93% - ≥95%
    Color and Shape:Solid
    Molecular weight:340.42

    Ref: TM-T1969

  • NMS-873
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    NMS-873

    CAS:
    <p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>
    Formula:C27H28N4O3S2
    Purity:99.05% - 99.85%
    Color and Shape:Solid
    Molecular weight:520.67

    Ref: TM-T1853

  • NPD8733
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    NPD8733

    CAS:
    <p>NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.</p>
    Formula:C18H15NO4
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:309.32

    Ref: TM-T9008

  • CB-5339
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    CB-5339

    CAS:
    <p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 &lt;30 nM [1].</p>
    Formula:C24H24N6O
    Purity:97.66%
    Color and Shape:Soild
    Molecular weight:412.49

    Ref: TM-T60193

  • UPCDC30766
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    UPCDC30766

    CAS:
    <p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>
    Formula:C30H32F2N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:594.68

    Ref: TM-T79255