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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1375 products of "Tyrosine Kinase/Adaptors"

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  • FMP-API-1
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    FMP-API-1

    CAS:
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Formula:C13H14N2O2
    Color and Shape:Solid
    Molecular weight:230.262

    Ref: TM-T204439

  • GENZ-882706
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    GENZ-882706

    CAS:
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Formula:C26H25N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:455.51

    Ref: TM-T11390

  • TRK-IN-26
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    TRK-IN-26

    CAS:
    <p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>
    Formula:C30H22F2N6O4
    Color and Shape:Solid
    Molecular weight:568.53

    Ref: TM-T87569

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    EGFR/HER2-IN-7

    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Formula:C19H21N3O2S
    Color and Shape:Solid
    Molecular weight:355.45

    Ref: TM-T61272

  • TrkC-IN-1
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    TrkC-IN-1

    CAS:
    <p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>
    Formula:C28H20BrN5O2
    Color and Shape:Solid
    Molecular weight:538.395

    Ref: TM-T206472

  • FGFR4-IN-4
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    FGFR4-IN-4

    CAS:
    <p>FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.</p>
    Formula:C28H32Cl2N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.5

    Ref: TM-T11280

  • TRK-IN-28
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    TRK-IN-28

    CAS:
    <p>TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].</p>
    Formula:C27H25F2N7
    Color and Shape:Solid
    Molecular weight:485.53

    Ref: TM-T87570

  • DDR1-IN-10
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    DDR1-IN-10

    CAS:
    <p>DDR1-IN-10 (compound 7q) is an inhibitor of DDR1. It is applicable in research related to pancreatic cancer, non-small cell lung cancer, and gastric cancer.</p>
    Formula:C24H25F4N5O2
    Color and Shape:Solid
    Molecular weight:491.481

    Ref: TM-T204839

  • NSC381467
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    NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formula:C20H16O7
    Color and Shape:Solid
    Molecular weight:368.34

    Ref: TM-T61441

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    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Formula:C33H28N6O3S
    Color and Shape:Solid
    Molecular weight:588.68

    Ref: TM-T64170

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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Formula:C14H11BrN4O2S
    Color and Shape:Solid
    Molecular weight:379.23

    Ref: TM-T61596

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    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Formula:C27H31ClN7O3P
    Color and Shape:Solid
    Molecular weight:568.01

    Ref: TM-T64020

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    EGFR-IN-24

    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Formula:C30H35FN6O3
    Color and Shape:Solid
    Molecular weight:546.64

    Ref: TM-T63857

  • TrkA-IN-7
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    TrkA-IN-7

    CAS:
    <p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>
    Formula:C16H13N3O3
    Color and Shape:Solid
    Molecular weight:295.293

    Ref: TM-T204489

  • JBJ-02-112-05
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    JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Formula:C27H20N4O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:464.54

    Ref: TM-T11713

  • Lucitanib dihydrochloride
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    Lucitanib dihydrochloride

    CAS:
    <p>Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient VEGFR1-3, FGFR1-3, and PDGFRalpha/β inhibitor, used in metastatic breast cancer research.</p>
    Formula:C26H27Cl2N3O4
    Color and Shape:Solid
    Molecular weight:516.42

    Ref: TM-T89507

  • PET-cGMP
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    PET-cGMP

    CAS:
    <p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>
    Formula:C18H16N5O7P
    Color and Shape:Solid
    Molecular weight:445.323

    Ref: TM-T204785

  • HER2-IN-6
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    HER2-IN-6

    CAS:
    <p>HER2-IN-6, a potent HER2 inhibitor, may target wild/mutant EGFR and HER2-mediated tumors. (Patent WO2021164697A1, compound 11)</p>
    Formula:C26H32N8O3
    Color and Shape:Solid
    Molecular weight:504.58

    Ref: TM-T63441

  • AMG-25
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    AMG-25

    CAS:
    <p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>
    Formula:C23H17N5O2
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:395.41

    Ref: TM-T22256

  • HER2-IN-8
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Color and Shape:Solid
    Molecular weight:549.53

    Ref: TM-T63881