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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1375 products of "Tyrosine Kinase/Adaptors"

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  • Tyrphostin A25
    Targetmol
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    Tyrphostin A25

    CAS:
    <p>Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.</p>
    Formula:C10H6N2O3
    Purity:98.76%
    Color and Shape:Yellow Green Powder /Off-White Solid
    Molecular weight:202.17

    Ref: TM-T21622

  • PKI-166
    Targetmol
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    PKI-166

    CAS:
    <p>PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth &amp; spread of many human cancers, including pancreatic.</p>
    Formula:C20H18N4O
    Purity:99.2%
    Color and Shape:Solid
    Molecular weight:330.38

    Ref: TM-T16549

  • RET-IN-3
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    RET-IN-3

    CAS:
    <p>RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.</p>
    Formula:C18H21N5O2
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:339.39

    Ref: TM-T9673

  • c-Fms-IN-13
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    c-Fms-IN-13

    CAS:
    <p>c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.</p>
    Formula:C22H26N4O2
    Purity:99.93% - 99.97%
    Color and Shape:Solid
    Molecular weight:378.47

    Ref: TM-T61589

  • EMI1
    Targetmol
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    EMI1

    CAS:
    <p>EMI1 targets mutated EGFR in drug-resistant NSCLC research.</p>
    Formula:C20H18N2O3
    Purity:99.96%
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T61016

  • EGFR-IN-9
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    EGFR-IN-9

    CAS:
    <p>EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).</p>
    Formula:C29H24N4O3
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:476.53

    Ref: TM-T11163

  • CSF1R-IN-3
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    CSF1R-IN-3

    CAS:
    <p>CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.</p>
    Formula:C30H38N8O4
    Purity:97.31%
    Color and Shape:Solid
    Molecular weight:574.67

    Ref: TM-T64066

  • A-935142
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    A-935142

    CAS:
    <p>A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.</p>
    Formula:C18H19F3N2O2
    Purity:98.97% - 99.91%
    Color and Shape:Solid
    Molecular weight:352.35

    Ref: TM-T14077

  • LDN-211904 oxalate
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    LDN-211904 oxalate

    CAS:
    <p>LDN-211904 oxalate (LDN211904 oxalate) is a selective and efficient EphB3 inhibitor with antitumor activity, useful in neurodegenerative disease research.</p>
    Formula:C21H21ClN4O5
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:444.87

    Ref: TM-T21762

  • AXL-IN-15
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    AXL-IN-15

    CAS:
    <p>AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1</p>
    Formula:C26H32F3N9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.59

    Ref: TM-T79045

  • AXL-IN-14
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    AXL-IN-14

    CAS:
    <p>AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.</p>
    Formula:C32H24F2N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:566.55

    Ref: TM-T73310

  • VEGFR-2-IN-37
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    VEGFR-2-IN-37

    CAS:
    <p>VEGFR-2-IN-37 (compound 12), a VEGFR-2 inhibitor, exhibits an inhibition rate of approximately 56.9 μM at a concentration of 200 μM.</p>
    Formula:C18H16N2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.4

    Ref: TM-T80872

  • BT424
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    BT424

    CAS:
    <p>BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].</p>
    Formula:C22H15BCl2N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:421.08

    Ref: TM-T79516

  • Brepocitinib
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    Brepocitinib

    CAS:
    <p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>
    Formula:C18H21F2N7O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:389.4

    Ref: TM-TQ0010

  • Axl/Mer/CSF1R-IN-2
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    Axl/Mer/CSF1R-IN-2

    CAS:
    <p>Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].</p>
    Formula:C24H22F3N5O5
    Color and Shape:Solid
    Molecular weight:517.46

    Ref: TM-T85780

  • Terevalefim
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    Terevalefim

    CAS:
    <p>Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.</p>
    Formula:C9H8N2S
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:176.24

    Ref: TM-T37596

  • Cinsebrutinib
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    Cinsebrutinib

    CAS:
    <p>Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.</p>
    Formula:C22H26FN3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:383.46

    Ref: TM-T79841

  • BMS-599626 Hydrochloride
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    BMS-599626 Hydrochloride

    CAS:
    <p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>
    Formula:C27H28ClFN8O3
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:567.01

    Ref: TM-T5390

  • FGFR3-IN-7
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    FGFR3-IN-7

    CAS:
    <p>FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>
    Formula:C25H24FN9O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:485.52

    Ref: TM-T82404

  • ARRY-382
    Targetmol
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    ARRY-382

    CAS:
    <p>ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.</p>
    Formula:C32H36N8O2
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:564.68

    Ref: TM-T35333

  • Tyrphostin AG1433
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    Tyrphostin AG1433

    CAS:
    <p>Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).</p>
    Formula:C16H14N2O2
    Purity:98.47%
    Color and Shape:Solid
    Molecular weight:266.29

    Ref: TM-T13238

  • Resigratinib
    Targetmol
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    Resigratinib

    CAS:
    <p>Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).</p>
    Formula:C26H27F2N7O3
    Purity:98.58%
    Color and Shape:Solid
    Molecular weight:523.53

    Ref: TM-T79856

  • BGB-102
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    BGB-102

    CAS:
    <p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>
    Formula:C22H25BrN4O2
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:457.36

    Ref: TM-T10531

  • AKB-6899
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    AKB-6899

    CAS:
    <p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>
    Formula:C14H11FN2O4
    Purity:97.87%
    Color and Shape:Solid
    Molecular weight:290.25

    Ref: TM-T29797

  • Lifirafenib
    Targetmol
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Formula:C25H17F3N4O3
    Purity:98% - 98.25%
    Color and Shape:Solid
    Molecular weight:478.42

    Ref: TM-T22272

  • VEGFR-2-IN-9
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    VEGFR-2-IN-9

    CAS:
    <p>VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor (IC50: 7 nM). It can be used to study breast cancer.</p>
    Formula:C23H25N3O3
    Purity:97.19%
    Color and Shape:Solid
    Molecular weight:391.46

    Ref: TM-T10123

  • EGFR mutant-IN-1
    Targetmol
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Formula:C34H39ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.17

    Ref: TM-T11164

  • JND3229
    Targetmol
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    JND3229

    CAS:
    <p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>
    Formula:C33H41ClN8O2
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:617.18

    Ref: TM-T15615

  • EGFR-IN-1
    Targetmol
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    EGFR-IN-1

    CAS:
    <p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>
    Formula:C28H30N6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:514.58

    Ref: TM-T11157

  • PF-06733804
    Targetmol
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    PF-06733804

    CAS:
    <p>PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.</p>
    Formula:C20H19F5N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.38

    Ref: TM-T13207

  • EGFR-IN-36
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    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Formula:C26H25ClN6O2
    Color and Shape:Solid
    Molecular weight:488.97

    Ref: TM-T63265

  • EGFR-IN-71
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    EGFR-IN-71

    CAS:
    <p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>
    Formula:C16H9ClIN3
    Color and Shape:Solid
    Molecular weight:405.62

    Ref: TM-T62009

  • Pirtobrutinib
    Targetmol
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    Pirtobrutinib

    CAS:
    <p>Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.</p>
    Formula:C22H21F4N5O3
    Purity:99.76% - 99.94%
    Color and Shape:Solid
    Molecular weight:479.43

    Ref: TM-T36287

  • VEGFR2-IN-3
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    VEGFR2-IN-3

    CAS:
    <p>VEGFR2-IN-3 (compound 385) is a potent inhibitor of VEGFR2 [1].</p>
    Formula:C26H28ClN5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.98

    Ref: TM-T79009

  • EGFR-IN-74
    Targetmol
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    EGFR-IN-74

    <p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>
    Formula:C32H28BrF3N6O4S
    Color and Shape:Solid
    Molecular weight:729.57

    Ref: TM-T73170

  • TIE-2/VEGFR-2 kinase-IN-5
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    TIE-2/VEGFR-2 kinase-IN-5

    CAS:
    <p>TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.</p>
    Formula:C21H13F6N5O2
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:481.35

    Ref: TM-T79860

  • Simotinib
    Targetmol
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    Simotinib

    CAS:
    <p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>
    Formula:C25H26ClFN4O4
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:500.95

    Ref: TM-T35916

  • EGFR-IN-29
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    EGFR-IN-29

    CAS:
    <p>EGFR-IN-29 is a potent EGFR inhibitor.</p>
    Formula:C36H46BrN8O2P
    Color and Shape:Solid
    Molecular weight:733.68

    Ref: TM-T73106

  • CG 428
    Targetmol
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    CG 428

    CAS:
    <p>CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM.</p>
    Formula:C43H43FN10O6
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:814.86

    Ref: TM-T41224

  • PAT-505
    Targetmol
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    PAT-505

    CAS:
    <p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>
    Formula:C23H18ClF2N3O2S
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:473.92

    Ref: TM-T12372

  • Edralbrutinib
    Targetmol
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    Edralbrutinib

    CAS:
    <p>Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood and</p>
    Formula:C26H21F2N5O3
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:489.47

    Ref: TM-T63272

  • DYRKs-IN-2
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    DYRKs-IN-2

    CAS:
    <p>DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.</p>
    Formula:C32H38ClN9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.16

    Ref: TM-T11133

  • c-met-IN-1
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    c-met-IN-1

    CAS:
    <p>c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.</p>
    Formula:C35H37FN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:640.7

    Ref: TM-T10653

  • HKI-357
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    HKI-357

    CAS:
    <p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>
    Formula:C31H29ClFN5O3
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:574.05

    Ref: TM-T11569

  • BMX-IN-1
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    BMX-IN-1

    CAS:
    <p>BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine</p>
    Formula:C29H24N4O4S
    Purity:98.38%
    Color and Shape:Solid
    Molecular weight:524.59

    Ref: TM-T14692

  • PF-06250112
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    PF-06250112

    CAS:
    <p>PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.</p>
    Formula:C22H20F2N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.43

    Ref: TM-T12673L

  • PF-06459988
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    PF-06459988

    CAS:
    <p>PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.</p>
    Formula:C19H22ClN7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.88

    Ref: TM-T16492

  • EGFR-IN-30
    Targetmol
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    EGFR-IN-30

    CAS:
    <p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, &lt;1 nM WT/mutants) with potential in cancer research.</p>
    Formula:C28H33BrN7O2P
    Color and Shape:Solid
    Molecular weight:610.49

    Ref: TM-T73108

  • HER2-IN-5
    Targetmol
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Formula:C27H33N7O3
    Color and Shape:Solid
    Molecular weight:503.6

    Ref: TM-T63432

  • Nazartinib S-enantiomer
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    Nazartinib S-enantiomer

    CAS:
    <p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>
    Formula:C26H31ClN6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:495.02

    Ref: TM-T11156