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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1375 products of "Tyrosine Kinase/Adaptors"

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  • AZ8010
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    AZ8010

    CAS:
    <p>AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.</p>
    Formula:C27H34N4O3
    Color and Shape:Solid
    Molecular weight:462.58

    Ref: TM-T89951

  • Andamertinib
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Formula:C31H36N8O3
    Color and Shape:Solid
    Molecular weight:568.669

    Ref: TM-T206579

  • KRC-00715
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    KRC-00715

    CAS:
    <p>KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.</p>
    Formula:C25H25F3N8O3
    Color and Shape:Solid
    Molecular weight:542.51

    Ref: TM-T200380

  • ROS1-IN-2
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    ROS1-IN-2

    CAS:
    <p>ROS1-IN-2 (Compound 3), a ROS1 inhibitor, is utilized in cancer research.</p>
    Formula:C29H37ClN5O2P
    Color and Shape:Solid
    Molecular weight:554.06

    Ref: TM-T89912

  • SST0116CL1
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    SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Formula:C22H31ClN4O6
    Color and Shape:Solid
    Molecular weight:482.96

    Ref: TM-T200022

  • ONO-7579
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    ONO-7579

    CAS:
    <p>ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.</p>
    Formula:C24H18ClF3N6O4S
    Color and Shape:Solid
    Molecular weight:578.95

    Ref: TM-T200301

  • MerTK/Axl-IN-1
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    MerTK/Axl-IN-1

    CAS:
    <p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>
    Formula:C40H47FN6O4
    Color and Shape:Solid
    Molecular weight:694.84

    Ref: TM-T200517

  • HS-345
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    HS-345

    CAS:
    <p>HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.</p>
    Formula:C19H18N6O2S
    Color and Shape:Solid
    Molecular weight:394.45

    Ref: TM-T200230

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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Formula:C26H28ClN3O4
    Color and Shape:Solid
    Molecular weight:481.97

    Ref: TM-T63189

  • Neptinib
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    Neptinib

    CAS:
    <p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>
    Formula:C22H23ClFN5O2
    Color and Shape:Solid
    Molecular weight:443.90

    Ref: TM-T89923

  • Tarloxotinib bromide
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    Tarloxotinib bromide

    CAS:
    <p>Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.</p>
    Formula:C24H24Br2ClN9O3
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:681.77

    Ref: TM-T13088

  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formula:C27H25ClN2O4
    Color and Shape:Solid
    Molecular weight:476.951

    Ref: TM-T204772

  • NMS-P626
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    NMS-P626

    CAS:
    <p>NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.</p>
    Formula:C28H35F2N7O4S
    Color and Shape:Solid
    Molecular weight:603.68

    Ref: TM-T200149

  • DYR530
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    DYR530

    CAS:
    <p>DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.</p>
    Formula:C23H24FN7
    Color and Shape:Solid
    Molecular weight:417.48

    Ref: TM-T201243

  • Enrupatinib
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    Enrupatinib

    CAS:
    <p>Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.</p>
    Formula:C27H26N6O3
    Color and Shape:Solid
    Molecular weight:482.53

    Ref: TM-T201165

  • DDR1/2 inhibitor-3
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    DDR1/2 inhibitor-3

    CAS:
    <p>DDR1/2 inhibitor-3 (5n) is an inhibitor of DDR1/2, with IC50 values of 9.4 nM and 20.4 nM, respectively. It is applicable in anti-inflammatory research.</p>
    Formula:C31H31F3N6O
    Color and Shape:Solid
    Molecular weight:560.613

    Ref: TM-T204457

  • c-Met-IN-26
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    c-Met-IN-26

    CAS:
    <p>c-Met-IN-26 (compound 1-170) is an effective inhibitor of c-Met, exhibiting an IC50 of 1.6 nM.</p>
    Formula:C24H19F2N9
    Color and Shape:Solid
    Molecular weight:471.46

    Ref: TM-T201085

  • Fanregratinib
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    Fanregratinib

    CAS:
    <p>Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.</p>
    Formula:C27H33ClN6O2
    Color and Shape:Solid
    Molecular weight:509.04

    Ref: TM-T201139

  • WS-11
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    WS-11

    CAS:
    <p>WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.</p>
    Formula:C26H22FN9O2
    Color and Shape:Solid
    Molecular weight:511.51

    Ref: TM-T201126

  • MerTK-IN-1
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    MerTK-IN-1

    CAS:
    <p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>
    Formula:C23H26N8O4
    Color and Shape:Solid
    Molecular weight:478.50

    Ref: TM-T200963

  • BPI-15086
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    BPI-15086

    CAS:
    <p>BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.</p>
    Formula:C29H33ClN8O4
    Color and Shape:Solid
    Molecular weight:593.08

    Ref: TM-T200004

  • Dyrk1A-IN-11
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    Dyrk1A-IN-11

    CAS:
    <p>Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.</p>
    Formula:C23H23F5N8O
    Color and Shape:Solid
    Molecular weight:522.47

    Ref: TM-T201128

  • BTK-IN-38
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    BTK-IN-38

    CAS:
    <p>BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.</p>
    Formula:C27H26F2N4O2
    Color and Shape:Solid
    Molecular weight:476.52

    Ref: TM-T201231

  • c-Kit-IN-8
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    c-Kit-IN-8

    CAS:
    <p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>
    Formula:C24H26FN5O4
    Color and Shape:Solid
    Molecular weight:467.49

    Ref: TM-T200947

  • ES-072
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    ES-072

    CAS:
    <p>ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.</p>
    Formula:C25H27F3N8O2
    Color and Shape:Solid
    Molecular weight:528.53

    Ref: TM-T200087

  • c-Met-IN-2
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    c-Met-IN-2

    CAS:
    <p>c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.</p>
    Formula:C24H21FN10O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.49

    Ref: TM-T10654

  • JBJ-09-063
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    JBJ-09-063

    CAS:
    <p>JBJ-09-063: EGFR inhibitor, IC50s 0.147-0.396 nM for various mutants; hinders EGFR/Akt/ERK1/2 phosphorylation; targets TKI-sensitive/resistant lung cancer.</p>
    Formula:C31H29FN4O3S
    Color and Shape:Solid
    Molecular weight:556.65

    Ref: TM-T63939

  • ITK inhibitor 2
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    ITK inhibitor 2

    CAS:
    <p>ITK inhibitor 2 (compound 4) is a potent and selective ITK inhibitor with an IC50= 2 nM.</p>
    Formula:C25H33N5O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:435.56

    Ref: TM-T11690

  • BTK-IN-16
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    BTK-IN-16

    CAS:
    <p>BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.</p>
    Formula:C15H14N4O2
    Purity:99.04%
    Color and Shape:Soild
    Molecular weight:282.3

    Ref: TM-T60542

  • D-69491 hydrochloride
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    D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Formula:C25H26Cl2FN7O3
    Color and Shape:Solid
    Molecular weight:562.42

    Ref: TM-T201568

  • Pred17
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    Pred17

    <p>Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.</p>
    Formula:C27H22BN3O
    Color and Shape:Solid
    Molecular weight:415.29

    Ref: TM-T201786

  • CGP062464
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    CGP062464

    CAS:
    <p>CGP062464 is an inhibitor of the tyrosine kinase c-Src, with an IC50 of less than 50 nM. It is utilized in research related to osteoporosis and tumor-induced hypercalcemia.</p>
    Formula:C18H14N4
    Color and Shape:Solid
    Molecular weight:286.331

    Ref: TM-T205732

  • EGFR-IN-133
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    EGFR-IN-133

    CAS:
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Formula:C27H29F2N7O3
    Color and Shape:Solid
    Molecular weight:537.56

    Ref: TM-T201790

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formula:C16H15N3OS
    Color and Shape:Solid
    Molecular weight:297.375

    Ref: TM-T205658

  • EGFR-IN-132
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    EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Formula:C27H31N7O3
    Color and Shape:Solid
    Molecular weight:501.58

    Ref: TM-T201638

  • NS-062
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    NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Formula:C28H30Cl2F2N6O4
    Color and Shape:Solid
    Molecular weight:623.48

    Ref: TM-T201773

  • FGFR-IN-15
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    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Formula:C22H23N5O5S
    Color and Shape:Solid
    Molecular weight:469.51

    Ref: TM-T201821

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    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Color and Shape:Solid

    Ref: TM-T64254

  • EGFR-IN-35
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    EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Formula:C25H24ClN7O2
    Color and Shape:Solid
    Molecular weight:489.96

    Ref: TM-T63282

  • LSD1/EGFR-IN-1
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formula:C21H20ClN3O4
    Color and Shape:Solid
    Molecular weight:413.854

    Ref: TM-T204471

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    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Color and Shape:Solid

    Ref: TM-T64255

  • EG31
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    EG31

    CAS:
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Formula:C30H13Br2N3O6
    Color and Shape:Solid
    Molecular weight:671.25

    Ref: TM-T207269

  • UniPR500
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    UniPR500

    CAS:
    <p>UniPR500, a derivative of UniPR129, is a competitive antagonist for the EphA2 receptor, with a Ki of 0.78 μM. It reduces the binding of biotinylated Ephrin-A1 to EphA2 in a dose-dependent manner, exhibiting an IC50 value of 1.1 μM.</p>
    Formula:C36H51N3O4
    Color and Shape:Solid
    Molecular weight:589.808

    Ref: TM-T204989

  • EGFR-IN-147
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    EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Formula:C13H13N5O
    Color and Shape:Solid
    Molecular weight:255.275

    Ref: TM-T204935

  • HER2-IN-21
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    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formula:C20H18N4O3S
    Color and Shape:Solid
    Molecular weight:394.447

    Ref: TM-T205331

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Formula:C10H8N2O
    Color and Shape:Solid
    Molecular weight:172.183

    Ref: TM-T204167

  • TYRA-300
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    TYRA-300

    CAS:
    <p>TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.</p>
    Formula:C25H24Cl2N6O3S
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:559.47

    Ref: TM-T88841

  • TrkA-IN-9
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    TrkA-IN-9

    CAS:
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Formula:C31H32N4O4
    Color and Shape:Solid
    Molecular weight:524.61

    Ref: TM-T206381

  • Pimicotinib hydrochloride
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    Pimicotinib hydrochloride

    CAS:
    <p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>
    Formula:C22H25ClN6O3
    Color and Shape:Solid
    Molecular weight:456.925

    Ref: TM-T204920

  • EGFR-IN-23
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    EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Formula:C36H44BrN10O3P
    Color and Shape:Solid
    Molecular weight:775.68

    Ref: TM-T73104