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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1375 products of "Tyrosine Kinase/Adaptors"

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  • FMP-API-1
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    FMP-API-1

    CAS:
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Formula:C13H14N2O2
    Color and Shape:Solid
    Molecular weight:230.262

    Ref: TM-T204439

  • GENZ-882706
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    GENZ-882706

    CAS:
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Formula:C26H25N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:455.51

    Ref: TM-T11390

  • TRK-IN-26
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    TRK-IN-26

    CAS:
    <p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>
    Formula:C30H22F2N6O4
    Color and Shape:Solid
    Molecular weight:568.53

    Ref: TM-T87569

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    EGFR/HER2-IN-7

    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Formula:C19H21N3O2S
    Color and Shape:Solid
    Molecular weight:355.45

    Ref: TM-T61272

  • TrkC-IN-1
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    TrkC-IN-1

    CAS:
    <p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>
    Formula:C28H20BrN5O2
    Color and Shape:Solid
    Molecular weight:538.395

    Ref: TM-T206472

  • FGFR4-IN-4
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    FGFR4-IN-4

    CAS:
    <p>FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.</p>
    Formula:C28H32Cl2N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.5

    Ref: TM-T11280

  • TRK-IN-28
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    TRK-IN-28

    CAS:
    <p>TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].</p>
    Formula:C27H25F2N7
    Color and Shape:Solid
    Molecular weight:485.53

    Ref: TM-T87570

  • DDR1-IN-10
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    DDR1-IN-10

    CAS:
    <p>DDR1-IN-10 (compound 7q) is an inhibitor of DDR1. It is applicable in research related to pancreatic cancer, non-small cell lung cancer, and gastric cancer.</p>
    Formula:C24H25F4N5O2
    Color and Shape:Solid
    Molecular weight:491.481

    Ref: TM-T204839

  • NSC381467
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    NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formula:C20H16O7
    Color and Shape:Solid
    Molecular weight:368.34

    Ref: TM-T61441

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    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Formula:C33H28N6O3S
    Color and Shape:Solid
    Molecular weight:588.68

    Ref: TM-T64170

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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Formula:C14H11BrN4O2S
    Color and Shape:Solid
    Molecular weight:379.23

    Ref: TM-T61596

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    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Formula:C27H31ClN7O3P
    Color and Shape:Solid
    Molecular weight:568.01

    Ref: TM-T64020

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    EGFR-IN-24

    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Formula:C30H35FN6O3
    Color and Shape:Solid
    Molecular weight:546.64

    Ref: TM-T63857

  • TrkA-IN-7
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    TrkA-IN-7

    CAS:
    <p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>
    Formula:C16H13N3O3
    Color and Shape:Solid
    Molecular weight:295.293

    Ref: TM-T204489

  • JBJ-02-112-05
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    JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Formula:C27H20N4O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:464.54

    Ref: TM-T11713

  • Lucitanib dihydrochloride
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    Lucitanib dihydrochloride

    CAS:
    <p>Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient VEGFR1-3, FGFR1-3, and PDGFRalpha/β inhibitor, used in metastatic breast cancer research.</p>
    Formula:C26H27Cl2N3O4
    Color and Shape:Solid
    Molecular weight:516.42

    Ref: TM-T89507

  • PET-cGMP
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    PET-cGMP

    CAS:
    <p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>
    Formula:C18H16N5O7P
    Color and Shape:Solid
    Molecular weight:445.323

    Ref: TM-T204785

  • HER2-IN-6
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    HER2-IN-6

    CAS:
    <p>HER2-IN-6, a potent HER2 inhibitor, may target wild/mutant EGFR and HER2-mediated tumors. (Patent WO2021164697A1, compound 11)</p>
    Formula:C26H32N8O3
    Color and Shape:Solid
    Molecular weight:504.58

    Ref: TM-T63441

  • AMG-25
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    AMG-25

    CAS:
    <p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>
    Formula:C23H17N5O2
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:395.41

    Ref: TM-T22256

  • HER2-IN-8
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Color and Shape:Solid
    Molecular weight:549.53

    Ref: TM-T63881

  • EGFR-IN-159
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    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formula:C21H23N3O5
    Color and Shape:Solid
    Molecular weight:397.424

    Ref: TM-T206989

  • EGFR-IN-38
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Formula:C25H24ClN7O2
    Color and Shape:Solid
    Molecular weight:489.96

    Ref: TM-T63283

  • EGFR-IN-125
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    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Formula:C30H26N8O
    Color and Shape:Solid
    Molecular weight:514.58

    Ref: TM-T204450

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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Formula:C31H30FN7O
    Color and Shape:Solid
    Molecular weight:535.61

    Ref: TM-T63774

  • HER2-IN-7
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    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Formula:C28H26F3N7O3
    Color and Shape:Solid
    Molecular weight:565.55

    Ref: TM-T64003

  • EGFR-IN-34
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    EGFR-IN-34

    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Formula:C26H27ClN6O2
    Color and Shape:Solid
    Molecular weight:490.98

    Ref: TM-T63300

  • Sacibertinib
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    Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Formula:C32H31ClN6O4
    Color and Shape:Solid
    Molecular weight:599.08

    Ref: TM-T64225

  • VEGFR2-IN-1
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    VEGFR2-IN-1

    CAS:
    <p>VEGFR2-IN-1 is a VEGFR2 inhibitor with antitumor activity used in the study of breast cancer.</p>
    Formula:C22H18N6S
    Purity:98.15%
    Color and Shape:Solid
    Molecular weight:398.48

    Ref: TM-T61899

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    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Formula:C16H16N4O2S
    Color and Shape:Solid
    Molecular weight:328.39

    Ref: TM-T60938

  • Tesevatinib tosylate
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Formula:C31H33Cl2FN4O5S
    Color and Shape:Solid
    Molecular weight:663.59

    Ref: TM-T201865

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    DDR1-IN-8

    CAS:
    <p>DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, exhibiting IC50 values of 0.045 μM and 0.126 μM, respectively, and possesses antitumor activity.</p>
    Formula:C23H24F3N5O2
    Molecular weight:459.46

    Ref: TM-T209082

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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Formula:C19H14BrF3N2O
    Color and Shape:Solid
    Molecular weight:423.23

    Ref: TM-T62271

  • BNN-20
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    BNN-20

    CAS:
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Formula:C20H30O2
    Color and Shape:Solid
    Molecular weight:302.45

    Ref: TM-T201864

  • EGFR-IN-135
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    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Formula:C12H14N4OS2
    Color and Shape:Solid
    Molecular weight:294.4

    Ref: TM-T201484

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    c-Fms-IN-15

    CAS:
    <p>c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.</p>
    Formula:C29H28F3N7O2
    Molecular weight:563.57

    Ref: TM-T210059

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    Protein kinase inhibitor 4

    CAS:
    <p>Protein kinase inhibitor 4 (Compound 3) is a chemical that acts as a protein kinase inhibitor, specifically targeting TRK-A with an IC50 of 3.0 nM, and ROS1 with an IC50 of 104 nM.</p>
    Formula:C25H24F2N6O3S
    Molecular weight:526.56

    Ref: TM-T209488

  • BML-265
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    BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Formula:C18H15N3O2
    Color and Shape:Solid
    Molecular weight:305.331

    Ref: TM-T204769

  • EGFR/VEGFR2-IN-2
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    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Formula:C24H15FO3
    Color and Shape:Solid
    Molecular weight:370.37

    Ref: TM-T201505

  • CL-A3-7
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    CL-A3-7

    CAS:
    <p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>
    Formula:C24H22Br2F2N2O3
    Color and Shape:Solid
    Molecular weight:584.25

    Ref: TM-T201641

  • 2-Methyl-3-phenylquinoxaline
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    2-Methyl-3-phenylquinoxaline

    CAS:
    <p>2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).</p>
    Formula:C15H12N2
    Color and Shape:Solid
    Molecular weight:220.27

    Ref: TM-T201514

  • EGFR-IN-130
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    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Formula:C27H25N3O6S
    Color and Shape:Solid
    Molecular weight:519.57

    Ref: TM-T201686

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    HER2-IN-12

    <p>HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.</p>
    Formula:C17H18BrN5O2S
    Color and Shape:Solid
    Molecular weight:436.33

    Ref: TM-T62487

  • FGFR-IN-16
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    FGFR-IN-16

    CAS:
    <p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>
    Formula:C30H27Cl2N7O4
    Color and Shape:Solid
    Molecular weight:620.49

    Ref: TM-T201714

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    EGFR/HER2-IN-4

    <p>EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.</p>
    Color and Shape:Solid

    Ref: TM-T64253

  • G-744
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    G-744

    CAS:
    <p>G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM).</p>
    Formula:C29H29N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:527.64

    Ref: TM-T15365

  • TAS05567
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    TAS05567

    CAS:
    <p>TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM).</p>
    Formula:C21H29N9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:439.51

    Ref: TM-T16995

  • EGFR-IN-126
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    EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Formula:C28H28BrFN4O3
    Color and Shape:Solid
    Molecular weight:567.45

    Ref: TM-T200496

  • EGFR-IN-160
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    EGFR-IN-160

    CAS:
    <p>EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).</p>
    Formula:C15H12N2O4
    Color and Shape:Solid
    Molecular weight:284.27

    Ref: TM-T207600

  • 8-Br-cGMP-AM
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    8-Br-cGMP-AM

    CAS:
    <p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>
    Formula:C13H15BrN5O9P
    Color and Shape:Solid
    Molecular weight:496.16

    Ref: TM-T88538

  • DYRKs-IN-1
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    DYRKs-IN-1

    CAS:
    <p>DYRKs-IN-1 has antitumor activity.</p>
    Formula:C30H30ClN7O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:588.06

    Ref: TM-T11132