Tyrosine Kinase/Adaptors
Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.
Subcategories of "Tyrosine Kinase/Adaptors"
- ALK(112 products)
- CSF-1R(42 products)
- EGFR(572 products)
- Ephrin Receptor(23 products)
- FLT(92 products)
- Fibroblast Growth Factor Receptor (FGFR)(170 products)
- HER(5 products)
- Hck(3 products)
- IGF-1R(86 products)
- PDGFR(126 products)
- PYK2(7 products)
- Src(78 products)
- TAM Receptor(32 products)
- Tie-2(20 products)
- Trk receptor(59 products)
- Tyrosine Kinases(27 products)
- VEGFR(268 products)
- c-Fms(108 products)
- c-Kit(101 products)
- c-Met/HGFR(128 products)
- c-RET(51 products)
Show 13 more subcategories
Found 1375 products of "Tyrosine Kinase/Adaptors"
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KLTWQELYQLKYKGI
CAS:<p>KLTWQELYQLKYKGI (QK) is a VEGF-mimicking peptide that competes with VEGF by binding to its receptors.</p>Formula:C92H143N21O23Purity:98%Color and Shape:SolidMolecular weight:1911.25FGFR1 inhibitor 7
<p>FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrum</p>Formula:C25H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:429.85EP26
<p>EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.</p>Formula:C42H42ClFN4O5Molecular weight:736.28278PF-04217903 phenolsulfonate
CAS:<p>PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).</p>Formula:C25H22N8O5SPurity:98%Color and Shape:SolidMolecular weight:546.56PD-360324
<p>PD-360324 is a human monoclonal antibody (mAb) that targets CSF1/M-CSF. It can be utilized in research related to skin lupus, pulmonary sarcoidosis, and rheumatoid arthritis.</p>Color and Shape:Odour LiquidBMS-599626
CAS:<p>BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.</p>Formula:C27H27FN8O3Purity:98.73%Color and Shape:SolidMolecular weight:530.55DS06652923
<p>DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.</p>Color and Shape:Odour SolidEGFR-IN-116
<p>EGFR-IN-116 (compound 14D) is an antineoplastic agent. It exhibits an IC50 value of 0.103 μM for EGFR, 0.069 μM for VEGFR-2, and 19.74 μM for Topo II.</p>Formula:C26H22N6O2SMolecular weight:482.1525PCI-33380
CAS:<p>PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.</p>Formula:C46H52BF2N11O3Purity:98%Color and Shape:SolidMolecular weight:855.8VEGFR-2-IN-55
<p>VEGFR-2-IN-55 (Compound 30) is an effective VEGFR-2 kinase inhibitor with an IC50 of 1.24 nM and exhibits anti-tumor activity.</p>Color and Shape:Odour SolidDSPE-PEG5000-GE11
<p>DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.</p>Color and Shape:Odour SolidSJF 1521
CAS:<p>SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.</p>Formula:C57H61ClFN7O9SPurity:99.20%Color and Shape:SolidMolecular weight:1074.65EGFR-IN-15
CAS:<p>EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.</p>Formula:C24H25BrN6O2Color and Shape:SolidMolecular weight:509.408Motesanib Diphosphate
CAS:<p>Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic</p>Formula:C22H23N5O·2H3PO4Purity:99.69%Color and Shape:SolidMolecular weight:569.44EGFR-IN-128
<p>EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.</p>Formula:C27H20N4OColor and Shape:SolidMolecular weight:416.47Depatuxizumab MMAF
<p>Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.</p>Color and Shape:LiquidMolecular weight:148.24 kDaPROTAC EGFR degrader 11
CAS:<p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>Formula:C49H64ClFN10O7SColor and Shape:SolidMolecular weight:991.61Anti-ERBB3/HER3 (29Z6)
<p>Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor targeting human ERBB3/HER3.</p>Color and Shape:Odour LiquidSU 5616
CAS:<p>SU 5616 (WAY-608241) regulates abnormal cell proliferation and modulates tyrosine kinase signaling.</p>Formula:C13H8ClNOSPurity:98.84%Color and Shape:SoildMolecular weight:261.73BMS-777607
CAS:<p>BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.</p>Formula:C25H19ClF2N4O4Purity:98.16% - 98.56%Color and Shape:SolidMolecular weight:512.89Cetuximab (PBS)
<p>Cetuximab (PBS) is a human IgG1 monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR), with a dissociation constant (Kd) of 0.201 nM for EGFR as measured by the SPR method. It exhibits potent antitumor activity.</p>Color and Shape:Odour LiquidARRY-380 (analog )
CAS:<p>ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.</p>Formula:C29H27N7O4SPurity:99.82%Color and Shape:SolidMolecular weight:569.63Matuzumab
CAS:<p>Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.</p>Purity:95%Color and Shape:LiquidMolecular weight:145.9 kDaZM 449829
CAS:<p>ZM 449829: Selective JAK3 inhibitor, binds to ATP site. pIC50: 6.8 for JAK3, others < 5.0.</p>Formula:C13H10OPurity:98%Color and Shape:SolidMolecular weight:182.222Lyso-Monosialoganglioside GM3
CAS:<p>Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.</p>Formula:C41H74N2O20Color and Shape:SolidMolecular weight:915.028Vislarafusp alfa
<p>Vislarafusp alfa is a humanized IgG1κ antibody that targets EGFR/CD47, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Color and Shape:Odour LiquidEGFR-IN-81
<p>EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69</p>Formula:C28H24F3N5O4Purity:98%Color and Shape:SolidMolecular weight:551.52T-1-MCPAB
<p>T-1-MCPAB, a VEGFR-2 inhibitor with an IC50 of 0.135 µM, effectively suppresses MCF7 cell migration and has applications in cancer research [1].</p>Purity:98%Color and Shape:Odour SolidNSC 12
CAS:<p>NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.</p>Formula:C24H34F6O3Purity:99.51%Color and Shape:SolidMolecular weight:484.52AG-1296
CAS:Formula:C16H14N2O2Purity:>98.0%(GC)Color and Shape:White to Orange to Green powder to crystalMolecular weight:266.30SB-505124
CAS:Formula:C20H21N3O2Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalineMolecular weight:335.41Bosutinib
CAS:Formula:C26H29Cl2N5O3Purity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:530.45SYN1143
CAS:<p>SYN1143 (AMG-1) strongly inhibits RON & c-Met with IC50s: 9 & 4 nmol/L.</p>Formula:C31H29FN4O5Purity:99.69%Color and Shape:SolidMolecular weight:556.58PP 1
CAS:Formula:C16H19N5Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:281.36BAY-826
CAS:<p>BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.</p>Formula:C26H19F5N6OSPurity:98% - 99.28%Color and Shape:SolidMolecular weight:558.53Cediranib
CAS:Formula:C25H27FN4O3Purity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:450.51CL-387785
CAS:Formula:C18H13BrN4OPurity:>98.0%(GC)Color and Shape:White to Light yellow powder to crystalMolecular weight:381.23Linifanib
CAS:Formula:C21H18FN5OPurity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:375.41Sunitinib Malate
CAS:Formula:C22H27FN4O2·C4H6O5Purity:>98.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:532.57SB-525334
CAS:Formula:C21H21N5Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:343.43Nintedanib
CAS:Formula:C31H33N5O4Purity:>95.0%(T)(HPLC)Color and Shape:White to Yellow to Yellow green powder to crystalMolecular weight:539.64Motesanib
CAS:Formula:C22H23N5OPurity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:373.46Imatinib Mesylate
CAS:Formula:C29H31N7O·CH4O3SPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:589.72PLX647
CAS:<p>PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).</p>Formula:C21H17F3N4Purity:99.38%Color and Shape:SolidMolecular weight:382.38Pazopanib
CAS:Formula:C21H23N7O2SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:437.52Vandetanib
CAS:Formula:C22H24BrFN4O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:475.36Canertinib
CAS:Formula:C24H25ClFN5O3Purity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:485.94PF-04217903 methanesulfonate
CAS:<p>PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).</p>Formula:C20H20N8O4SPurity:98%Color and Shape:SolidMolecular weight:468.49GDC-0834
CAS:<p>GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and</p>Formula:C33H36N6O3SColor and Shape:SolidMolecular weight:596.74MNS
CAS:Formula:C9H7NO4Purity:>98.0%(GC)Color and Shape:Light yellow to Yellow to Green powder to crystalMolecular weight:193.16
