GRK
G protein-coupled receptor kinases (GRKs) are a family of enzymes that phosphorylate activated GPCRs, leading to receptor desensitization and regulation of receptor signaling. GRKs play critical roles in controlling the intensity and duration of GPCR signaling, making them important in the regulation of various physiological processes, including cardiovascular function, immune response, and neurotransmission. GRK inhibitors and activators are studied for their potential therapeutic applications in heart failure, cancer, and neurological disorders. At CymitQuimica, we provide a range of high-quality GRK modulators to support your research in signal transduction, receptor regulation, and therapeutic development.
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GSK270822A
CAS:864082-23-5
GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, …
Formula:
C24H20N4O2
Purity:
98.13% - 98.77%
Color and Shape:
Liquid
Molecular weight:
396.44
Ref: TM-T27467
| 1mg | 142.00 € | ||
| 5mg | 335.00 € | ||
| 10mg | 445.00 € | ||
| 25mg | 674.00 € | ||
| 50mg | 904.00 € | ||
| 100mg | 1,210.00 € | ||
| 200mg | 1,613.00 € | ||
| 1mL*10mM (DMSO) | 344.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
GRK2-IN-1 hydrochloride (2055990-90-2 free base)
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 …
Formula:
C24H26ClFN4O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
488.94
Ref: TM-T13714L
| 1mg | 106.00 € | ||
| 2mg | 169.00 € | ||
| 5mg | 294.00 € | ||
| 10mg | 459.00 € | ||
| 25mg | 824.00 € | ||
| 50mg | 1,372.00 € | ||
| 100mg | 1,870.00 € | ||
| 200mg | To inquire | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 316.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
GRK6-IN-2
CAS:2677786-27-3
GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 …
Formula:
C21H21FN6
Purity:
98.94%
Color and Shape:
Liquid
Molecular weight:
376.43
Ref: TM-T61556
| 2mg | 61.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 301.00 € | ||
| 50mg | 462.00 € | ||
| 100mg | 694.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Takeda103A
CAS:865609-72-9
Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.
Formula:
C24H23F2N7O
Purity:
97.17%
Color and Shape:
Solid
Molecular weight:
463.48
Ref: TM-T24850
| 1mg | 82.00 € | ||
| 2mg | 102.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 249.00 € | ||
| 25mg | 409.00 € | ||
| 50mg | 543.00 € | ||
| 100mg | 759.00 € | ||
| 200mg | 999.00 € | ||
| 1mL*10mM (DMSO) | 180.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
![1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID](https://static.cymitquimica.com/products/TM/thumb/T8913.jpg)
1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:260555-42-8
1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.
Formula:
C13H13NO5
Purity:
99.78%
Color and Shape:
Solid
Molecular weight:
263.25
Ref: TM-T8913
| 5mg | 35.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 110.00 € | ||
| 100mg | 164.00 € | ||
| 200mg | 238.00 € | ||
| 1mL*10mM (DMSO) | 44.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
CCG215022
CAS:1813527-81-9
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 …
Formula:
C26H22FN7O3
Purity:
97.46% - 99.69%
Color and Shape:
Solid
Molecular weight:
499.5
Ref: TM-T3498
| 1mg | 94.00 € | ||
| 2mg | 138.00 € | ||
| 5mg | 231.00 € | ||
| 10mg | 369.00 € | ||
| 25mg | 616.00 € | ||
| 50mg | 877.00 € | ||
| 100mg | 1,196.00 € | ||
| 500mg | 2,385.00 € | ||
| 1mL*10mM (DMSO) | 257.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
GRK5-IN-2
CAS:1642839-27-7
GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.
Formula:
C20H20N4O4
Purity:
99.61%
Color and Shape:
Solid
Molecular weight:
380.4
Ref: TM-T9609
| 2mg | 35.00 € | ||
| 5mg | 49.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 141.00 € | ||
| 50mg | 218.00 € | ||
| 100mg | 323.00 € | ||
| 200mg | 451.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Friday 10 Jan 2025
GSK299115A
CAS:864082-35-9
GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for …
Formula:
C20H16Cl2N4O2
Purity:
98.99%
Color and Shape:
Solid
Molecular weight:
415.27
Ref: TM-T27471
| 1mg | 319.00 € | ||
| 5mg | 772.00 € | ||
| 10mg | 1,072.00 € | ||
| 25mg | 1,594.00 € | ||
| 50mg | 2,144.00 € | ||
| 100mg | 2,817.00 € | ||
| 1mL*10mM (DMSO) | 944.00 € |
Estimated delivery in United States, on Friday 21 Feb 2025
GRK6-IN-1
CAS:2677786-61-5
GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing …
Formula:
C22H23ClN6O2
Purity:
99.37%
Color and Shape:
Liquid
Molecular weight:
438.91
Ref: TM-T62518
| 1mg | 56.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 423.00 € | ||
| 50mg | 730.00 € | ||
| 100mg | 1,187.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Friday 21 Feb 2025
CCG258208
CAS:2055990-90-2
GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: …
Formula:
C24H25FN4O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
452.48
Ref: TM-T13714
| 25mg | 2,245.00 € | ||
| 50mg | 2,974.00 € | ||
| 100mg | 4,021.00 € |
Estimated delivery in United States, on Friday 4 Apr 2025
