GRK
G protein-coupled receptor kinases (GRKs) are a family of enzymes that phosphorylate activated GPCRs, leading to receptor desensitization and regulation of receptor signaling. GRKs play critical roles in controlling the intensity and duration of GPCR signaling, making them important in the regulation of various physiological processes, including cardiovascular function, immune response, and neurotransmission. GRK inhibitors and activators are studied for their potential therapeutic applications in heart failure, cancer, and neurological disorders. At CymitQuimica, we provide a range of high-quality GRK modulators to support your research in signal transduction, receptor regulation, and therapeutic development.
Found 31 products of "GRK"
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CMPD101
CAS:<p>CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).</p>Formula:C24H21F3N6OPurity:99.01% - 99.04%Color and Shape:SolidMolecular weight:466.46Corazonin
CAS:<p>Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.</p>Formula:C62H83N17O19Color and Shape:SolidMolecular weight:1370.42CCG258208 hydrochloride
<p>GRKs-IN-1 HCl (14as) strongly inhibits GRK2 (IC50=130nM) & GRK5 (IC50=7.1μM), is a paroxetine derivative with 100x cardiac boost.</p>Color and Shape:SolidGRL018-21
<p>GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].</p>Color and Shape:Odour SolidGSK270822A
CAS:<p>GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.</p>Formula:C24H20N4O2Purity:98.64% - 99.78%Color and Shape:SolidMolecular weight:396.44GRK-IN-1
CAS:<p>4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.</p>Formula:C6H10Br3N3Color and Shape:SolidMolecular weight:363.879Endothelin-3, human, mouse, rabbit, rat
CAS:<p>Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.</p>Formula:C121H168N26O33S4Purity:98%Color and Shape:SolidMolecular weight:2643.04GRK2i
CAS:<p>GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.</p>Formula:C153H256N50O41SPurity:98%Color and Shape:SolidMolecular weight:3484.08GRK2-IN-1 hydrochloride (2055990-90-2 free base)
<p>GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>Formula:C24H26ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:488.94GRL093-22
<p>GRL093-22 is an effective and selective inhibitor of G protein-coupled receptor kinases (GRK), with IC50 values of 60 nM for GRK5 and 40 nM for GRK6. It shows potential for research in heart failure and multiple myeloma.</p>Formula:C33H29FN6O3Color and Shape:SolidMolecular weight:576.62GSK180736A
CAS:<p>GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).</p>Formula:C19H16FN5O2Purity:98.38% - 98.98%Color and Shape:SolidMolecular weight:365.36CCG215022
CAS:<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Formula:C26H22FN7O3Purity:97.63% - 99.69%Color and Shape:SolidMolecular weight:499.51-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:<p>1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.</p>Formula:C13H13NO5Purity:99.55%Color and Shape:SolidMolecular weight:263.25Takeda103A
CAS:<p>Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.</p>Formula:C24H23F2N7OPurity:97.17%Color and Shape:SolidMolecular weight:463.48GRK6-IN-2
CAS:<p>GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.</p>Formula:C21H21FN6Purity:98.94%Color and Shape:SolidMolecular weight:376.43KR-39038
CAS:<p>KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.</p>Formula:C24H32ClFN6OColor and Shape:SolidMolecular weight:475.00GRK5-IN-3
CAS:<p>GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).</p>Formula:C23H21N7O3Color and Shape:SolidMolecular weight:443.46GSK317354A
CAS:<p>GSK317354A is a GRK2 inhibitor.</p>Formula:C25H18F4N6OColor and Shape:SolidMolecular weight:494.44CCG-271423
CAS:<p>CCG-271423: potent GRK5 inhibitor (IC50: 0.0021 μM), less on GRK2 (IC50: 44 μM); lowers Ca2+ events and heart cell contractility.</p>Formula:C28H26N4O3Color and Shape:SolidMolecular weight:466.53GRK5-IN-4
CAS:<p>GRK5-IN-4: potent, selective covalent inhibitor of GRK5 (IC50=1.1 μM), 90x more specific than GRK2, useful for heart failure research.</p>Formula:C26H25N7O3Color and Shape:SolidMolecular weight:483.52
![1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8913.webp&w=3840&q=75)
