PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(158 products)
- ATM/ATR(71 products)
- DNA-PK(51 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(242 products)
- S6 Kinase(9 products)
- gsk-3(112 products)
- mTOR(144 products)
Show 2 more subcategories
Found 1038 products of "PI3K/Akt/mTOR Signaling"
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EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
<p>The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.</p>Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted)EGFR Protein, Human, Recombinant (His & Avi)
<p>EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Color and Shape:Lyophilized PowderMolecular weight:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
<p>EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Color and Shape:Lyophilized PowderMolecular weight:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.Kinetin triphosphate tetrasodium
<p>Kinetin triphosphate tetrasodium is salt form of Kinetin triphosphate KTP, an ATP analog that enhances activity of Parkinson's disease-associated mutant PINK1.</p>Formula:C15H16N5Na4O14P3Purity:96.80%Color and Shape:SoildMolecular weight:675.19Brivanib
CAS:<p>Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against</p>Formula:C19H19FN4O3Purity:98.87%Color and Shape:SolidMolecular weight:370.38EGFR vIII Protein, Human, Recombinant (hFc)
<p>EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.</p>Color and Shape:Lyophilized PowderMolecular weight:90-120 KDa (reducing condition)PI3K-IN-30
CAS:<p>PI3K-IN-30 (compound 6d) 是一种 PI3K 的有效抑制剂，能够作用于 PI3Kα (IC50: 5.1 nM)、PI3Kβ (IC50: 136 nM)、PI3Kγ (IC50: 30.7 nM) 和 PI3Kδ (IC50: 8.9 nM)。</p>Formula:C20H25F2N7O3Color and Shape:SolidMolecular weight:449.45AV-412 free base
CAS:<p>AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).</p>Formula:C27H28ClFN6OColor and Shape:SolidMolecular weight:507Mavelertinib
CAS:<p>Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.</p>Formula:C18H22FN9O2Purity:99.89%Color and Shape:SolidMolecular weight:415.42Osimertinib dimesylate
CAS:<p>Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).</p>Formula:C30H41N7O8S2Purity:98%Color and Shape:SolidMolecular weight:691.82Neratinib maleate
CAS:<p>Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.</p>Formula:C34H33ClN6O7Purity:99.64%Color and Shape:SolidMolecular weight:673.11Rociletinib hydrobromide
CAS:<p>Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).</p>Formula:C27H29BrF3N7O3Purity:98%Color and Shape:SolidMolecular weight:636.46Rilematovir
CAS:<p>Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.</p>Formula:C21H20ClF3N4O3SPurity:99.82%Color and Shape:SolidMolecular weight:500.92Ceftriaxone Sodium
CAS:<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formula:C18H17N8NaO7S3Color and Shape:SolidMolecular weight:576.562AMA-37
CAS:<p>AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.</p>Formula:C17H17NO3Purity:98%Color and Shape:SolidMolecular weight:283.32Tyrphostin 8
CAS:<p>Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein</p>Formula:C10H6N2OPurity:99.86%Color and Shape:SolidMolecular weight:170.17Anti-EGFR Monoclonal Antibody-Biotin
<p>Antibody Type: Rabbit Monoclonal<br><br>Application: FCM<br><br>Reactivity: Human</p>Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaAnti-EGFR Monoclonal Antibody
<p>Antibody Type: Rabbit Monoclonal<br><br>Application: FCM<br><br>Reactivity: Human</p>Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaSulforaphene
CAS:<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Formula:C6H9NOS2Purity:97.55% - 99.19%Color and Shape:Slightly Yellowish LiquidMolecular weight:175.27TX1-85-1
CAS:<p>TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.</p>Formula:C32H36N8O3Purity:98.12% - 98.12%Color and Shape:SolidMolecular weight:580.68Tyrphostin B44, (+) enantiomer
CAS:<p>Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)</p>Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33GSK2334470
CAS:<p>GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.</p>Formula:C25H34N8OPurity:99.57% - 99.87%Color and Shape:SolidMolecular weight:462.59GNE-317
CAS:<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Formula:C19H22N6O3SPurity:98.42% - 99.54%Color and Shape:SolidMolecular weight:414.48Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Formula:C23H27N5O5SPurity:97.69% - 99.25%Color and Shape:SolidMolecular weight:485.56RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37Olafertinib
CAS:<p>Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.</p>Formula:C29H28F2N6O2Purity:98.62% - 99.706%Color and Shape:SolidMolecular weight:530.57TGX-221
CAS:<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formula:C21H24N4O2Purity:99.68% - >99.99%Color and Shape:SolidMolecular weight:364.44AG-1557 hydrochloride (189290-58-2(free base))
<p>AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formula:C16H15ClIN3O2Purity:98.64%Color and Shape:SolidMolecular weight:443.66PD-161570
CAS:<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formula:C26H35Cl2N7OPurity:99.92%Color and Shape:SolidMolecular weight:532.51IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formula:C22H20FN3O2Purity:99.42% - >99.99%Color and Shape:SolidMolecular weight:377.41Trastuzumab
CAS:<p>Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.</p>Purity:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Color and Shape:LiquidMolecular weight:Approximately 145.53 kDaAR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formula:C12H12N4O4SPurity:>99.99% - ≥95%Color and Shape:SolidMolecular weight:308.31AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Formula:C22H24N4O4Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:408.45Saracatinib
CAS:<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Formula:C27H32ClN5O5Purity:98% - 99.63%Color and Shape:SolidMolecular weight:542.03BI-4020
CAS:<p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>Formula:C30H38N8O2Purity:97.21% - >99.99%Color and Shape:SolidMolecular weight:542.68AEE788
CAS:<p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>Formula:C27H32N6Purity:98% - >99.99%Color and Shape:SolidMolecular weight:440.58(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formula:C29H35ClFN7O3Purity:99.64%Color and Shape:SolidMolecular weight:584.08KU-0063794
CAS:<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Formula:C25H31N5O4Purity:98.21% - >99.99%Color and Shape:SolidMolecular weight:465.54GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29Butein
CAS:<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Formula:C15H12O5Purity:98.76% - >99.99%Color and Shape:SolidMolecular weight:272.25YKL-05-099
CAS:<p>YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 and SIK3.Cost-effective and quality-assured.</p>Formula:C32H34ClN7O3Purity:99.57% - 99.66%Color and Shape:SolidMolecular weight:600.11WS6
CAS:<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formula:C29H31F3N6O3Purity:97.65% - 99.95%Color and Shape:SolidMolecular weight:568.59Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Formula:C23H20FN7OPurity:97.96%Color and Shape:SolidMolecular weight:429.45PKI-166 hydrochloride
CAS:<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Formula:C20H19ClN4OColor and Shape:SolidMolecular weight:366.85UCB9608
CAS:<p>UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.</p>Formula:C20H26N8O2Purity:97.53% - 99.59%Color and Shape:SolidMolecular weight:410.47OSI-027
CAS:<p>OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.</p>Formula:C21H22N6O3Purity:97.42%Color and Shape:SolidMolecular weight:406.44NRC-2694
CAS:<p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>Formula:C24H26N4O3Purity:99.90%Color and Shape:SolidMolecular weight:418.49Tuxobertinib
CAS:<p>Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.</p>Formula:C29H29ClN6O4Purity:99.22%Color and Shape:SolidMolecular weight:561.03GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formula:C18H22N8O2Purity:99.72% - 99.87%Color and Shape:SolidMolecular weight:382.42Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formula:C30H24N8O2Purity:99.04% - 99.28%Color and Shape:SolidMolecular weight:528.56YKL-06-061
CAS:<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Formula:C30H37N7O2Purity:99.52% - 99.79%Color and Shape:SolidMolecular weight:527.66CL-387785
CAS:<p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>Formula:C18H13BrN4OPurity:99.56% - 99.62%Color and Shape:SolidMolecular weight:381.23WS3
CAS:<p>WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formula:C28H30F3N7O3Purity:97.93% - 99.94%Color and Shape:SolidMolecular weight:569.58NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formula:C20H14F3N3SPurity:99.84% - 99.9%Color and Shape:SolidMolecular weight:385.41TAS0728
CAS:<p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>Formula:C26H32N8O3Purity:97.78%Color and Shape:SolidMolecular weight:504.58Mutant EGFR inhibitor
CAS:<p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>Formula:C27H30ClN7O2Purity:98% - 99.75%Color and Shape:SolidMolecular weight:520.03BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formula:C28H25F3N6O2Purity:95.74% - 99.51%Color and Shape:SolidMolecular weight:534.53GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purity:98.06%Color and Shape:SolidMolecular weight:360.19RG13022
CAS:<p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>Formula:C16H14N2O2Purity:98.38%Color and Shape:SolidMolecular weight:266.29Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formula:C25H24N4O2Purity:98.19% - 98.75%Color and Shape:Orange SolidMolecular weight:412.48NU 7026
CAS:<p>NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition</p>Formula:C17H15NO3Purity:99.51% - >99.99%Color and Shape:SolidMolecular weight:281.31KI8751
CAS:<p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>Formula:C24H18F3N3O4Purity:99.22% - 99.9%Color and Shape:SolidMolecular weight:469.41JCN037
CAS:<p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>Formula:C16H11BrFN3O2Purity:99.5%Color and Shape:SolidMolecular weight:376.18PF-6274484
CAS:<p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>Formula:C18H14ClFN4O2Purity:97.71%Color and Shape:SolidMolecular weight:372.78ARN-3236
CAS:<p>ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM</p>Formula:C19H16N2O2SPurity:98.89% - 99.7%Color and Shape:SolidMolecular weight:336.41Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Formula:C28H31F3N8O2Purity:99.87%Color and Shape:SolidMolecular weight:568.59MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Formula:C18H16N2O2Purity:99.66%Color and Shape:SolidMolecular weight:292.33ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formula:C19H21F2N7O2Purity:98.29% - 99.95%Color and Shape:White PowderMolecular weight:417.41Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Formula:C30H29ClN6O3Purity:96.17% - 99.85%Color and Shape:SolidMolecular weight:557.04AZD8931 diFuMaric acid
CAS:<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Formula:C31H33ClFN5O11Purity:99.92%Color and Shape:SolidMolecular weight:706.1KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurity:97.14% - 98.99%Color and Shape:Tan SolidMolecular weight:327.18Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46Poziotinib hydrochloride
CAS:<p>Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.</p>Formula:C23H22Cl3FN4O3Purity:99.69% - 99.81%Color and Shape:SolidMolecular weight:527.8AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Formula:C16H12N2O3Purity:98.69%Color and Shape:SolidMolecular weight:280.28Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purity:98.3% - 99.33%Color and Shape:SolidMolecular weight:607.62Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formula:C29H32N6O8Color and Shape:SolidMolecular weight:592.6Idelalisib
CAS:<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.42HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formula:C29H34ClN7OPurity:99.75% - >99.99%Color and Shape:SolidMolecular weight:532.08AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formula:C22H28FN9O3SPurity:≥98%Color and Shape:SolidMolecular weight:517.58TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formula:C10H10N2O2SPurity:97.13% - 99.61%Color and Shape:White SolidMolecular weight:222.26HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formula:C26H28N8OPurity:98.38% - 99.70%Color and Shape:SolidMolecular weight:468.55AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formula:C16H18N2OPurity:98.12%Color and Shape:SolidMolecular weight:254.33Tyrphostin AG30
CAS:<p>Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.</p>Formula:C10H7NO4Purity:99.02%Color and Shape:SolidMolecular weight:205.17ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Formula:C19H16BrFN6O2Purity:99.12%Color and Shape:SolidMolecular weight:459.27PP2
CAS:<p>PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.</p>Formula:C15H16ClN5Purity:98% - 98.21%Color and Shape:White SolidMolecular weight:301.77PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Formula:C11H9N5Purity:98.61%Color and Shape:Whit To Off-White SolidMolecular weight:211.22PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44CC-115 hydrochloride
CAS:<p>CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.</p>Formula:C16H17ClN8OColor and Shape:SolidMolecular weight:372.82WYE-687 dihydrochloride
CAS:<p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>Formula:C28H34Cl2N8O3Color and Shape:SolidMolecular weight:601.53Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formula:C29H31Cl2FN4OColor and Shape:SolidMolecular weight:541.494-Chloro-2'-bromoacetophenone
CAS:<p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>Formula:C8H6BrClOPurity:98.34% - 99.41%Color and Shape:White To Beige SolidMolecular weight:233.49WHI-P180
CAS:<p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>Formula:C16H15N3O3Purity:99.21%Color and Shape:SolidMolecular weight:297.31KU-57788
CAS:<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Formula:C25H19NO3SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:413.49AMG319
CAS:<p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.</p>Formula:C21H16FN7Purity:98.9% - 99.24%Color and Shape:Crystalline SolidMolecular weight:385.4SU5204
CAS:<p>SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and</p>Formula:C17H15NO2Purity:99.46%Color and Shape:SolidMolecular weight:265.31PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS:<p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>Formula:C18H21Cl3N4OPurity:99.5%Color and Shape:SolidMolecular weight:415.75WHI-P154
CAS:<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formula:C16H14BrN3O3Purity:98% - 99.67%Color and Shape:SolidMolecular weight:376.2Olmutinib
CAS:<p>Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor</p>Formula:C26H26N6O2SPurity:99.14%Color and Shape:SolidMolecular weight:486.59
