PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(158 products)
- ATM/ATR(71 products)
- DNA-PK(51 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(242 products)
- S6 Kinase(9 products)
- gsk-3(112 products)
- mTOR(144 products)
Show 2 more subcategories
Found 1038 products of "PI3K/Akt/mTOR Signaling"
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Duvelisib
CAS:<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Formula:C22H17ClN6OPurity:98.87% - 99.74%Color and Shape:SolidMolecular weight:416.86PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formula:C16H14BrN5O4SPurity:98.52% - >99.99%Color and Shape:SolidMolecular weight:452.28PD153035
CAS:<p>PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,</p>Formula:C16H14BrN3O2Purity:98.47% - 99.29%Color and Shape:SolidMolecular weight:360.21Acalisib
CAS:<p>Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.</p>Formula:C21H16FN7OPurity:98.99% - ≥95%Color and Shape:SolidMolecular weight:401.4Nazartinib
CAS:<p>Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (</p>Formula:C26H31ClN6O2Purity:98.63% - ≥95%Color and Shape:Solid PowderMolecular weight:495.02Vacuolin-1
CAS:<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formula:C26H24IN7OPurity:97.20% - 98.45%Color and Shape:SolidMolecular weight:577.42HG-9-91-01
CAS:<p>HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and</p>Formula:C32H37N7O3Purity:96.86% - 99.71%Color and Shape:SolidMolecular weight:567.68CZC24832
CAS:<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Formula:C15H17FN6O2SPurity:99.08% - 99.12%Color and Shape:SolidMolecular weight:364.4PD-089828
CAS:<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formula:C18H18Cl2N6OPurity:97.39%Color and Shape:SolidMolecular weight:405.28Parsaclisib hydrochloride
CAS:<p>Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.</p>Formula:C20H23Cl2FN6O2Purity:98%Color and Shape:SolidMolecular weight:469.34COH-SR4
CAS:<p>COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.</p>Formula:C13H8Cl4N2OPurity:98.96%Color and Shape:SolidMolecular weight:350.03RLY-2608
CAS:<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Formula:C29H14ClF5N6O2Purity:98.62% - 98.7%Color and Shape:SolidMolecular weight:608.91740 Y-P
CAS:<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>Formula:C141H222N43O39PS3Purity:98.3% - 99.87%Color and Shape:SolidMolecular weight:3270.7Gefitinib hydrochloride
CAS:<p>Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.</p>Formula:C22H25Cl2FN4O3Purity:99.8%Color and Shape:SolidMolecular weight:483.36CHIR 98024
CAS:<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formula:C20H17Cl2N9O2Purity:96.74%Color and Shape:SolidMolecular weight:486.31Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458BMS-690514
CAS:<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formula:C19H24N6O2Purity:99.08%Color and Shape:SolidMolecular weight:368.43Naquotinib mesylate
CAS:<p>Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR</p>Formula:C31H46N8O6SPurity:98%Color and Shape:SolidMolecular weight:658.81Canertinib dihydrochloride
CAS:<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formula:C24H27Cl3FN5O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:558.86Almonertinib hydrochloride
CAS:<p>Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.</p>Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.1Imgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Color and Shape:LiquidMolecular weight:145.0 (kDa)Depatuxizumab
CAS:<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Purity:95%Color and Shape:LiquidElgemtumab
CAS:<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Purity:95%Color and Shape:LiquidZalutumumab
CAS:<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Purity:95%Color and Shape:LiquidIzalontamab
CAS:<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Purity:95%+ - 95%+Color and Shape:LiquidBecotatug
CAS:<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Purity:95% - 95%Color and Shape:LiquidAnbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Color and Shape:LiquidPonezumab
CAS:<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Color and Shape:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Purity:95% - 95%Color and Shape:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Color and Shape:LiquidSerclutamab
CAS:<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Purity:98%Color and Shape:Liquid1-Azakenpaullone
CAS:<p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>Formula:C15H10BrN3OPurity:99.73%Color and Shape:Tan SolidMolecular weight:328.16Icotinib
CAS:<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Formula:C22H21N3O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:391.42IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Color and Shape:SolidMolecular weight:387.39lavendustin A
CAS:<p>lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.</p>Formula:C21H19NO6Purity:98%Color and Shape:Off-White SolidMolecular weight:381.38GSK2292767
CAS:<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Formula:C24H28N6O5SPurity:98%Color and Shape:SolidMolecular weight:512.58ZM323881 hydrochloride
CAS:<p>ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.</p>Formula:C22H19ClFN3O2Purity:99.43%Color and Shape:SolidMolecular weight:411.86CNX-1351
CAS:<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formula:C30H35N7O3SPurity:99.66% - 99.83%Color and Shape:SolidMolecular weight:573.71Icotinib Hydrochloride
CAS:<p>Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.</p>Formula:C22H22ClN3O4Purity:99.89%Color and Shape:SolidMolecular weight:427.88TAK-285
CAS:<p>TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.</p>Formula:C26H25ClF3N5O3Purity:99.73%Color and Shape:SolidMolecular weight:547.96CAL-130
CAS:<p>CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47TCS 2002
CAS:<p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>Formula:C18H14N2O3SColor and Shape:SolidMolecular weight:338.38MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formula:C47H56ClFN8O8Color and Shape:SolidMolecular weight:915.45PI3K/mTOR Inhibitor-9
CAS:<p>PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).</p>Formula:C23H27N7O2Color and Shape:SolidMolecular weight:433.51EGFR-IN-16
CAS:<p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>Formula:C16H11NO3Purity:98%Color and Shape:SolidMolecular weight:265.26NVP-CLR457
CAS:<p>NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.</p>Formula:C18H20F3N7O4Color and Shape:SolidMolecular weight:455.39NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Formula:C18H17NO3Purity:98%Color and Shape:SolidMolecular weight:295.33EGA
CAS:<p>EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.</p>Formula:C16H16BrN3OPurity:98% - 99.6%Color and Shape:SolidMolecular weight:346.22EGFR-IN-67
CAS:<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formula:C18H17N3SColor and Shape:SolidMolecular weight:307.41DS21360717
CAS:<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Formula:C21H23N7OPurity:98%Color and Shape:SolidMolecular weight:389.45DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Formula:C23H26N8O2Color and Shape:SolidMolecular weight:446.5WR23
CAS:<p>WR23 is a piperidinylquinoxaline derivative and a phosphoinositide 3-kinase α (PI3Kα) inhibitor.</p>Formula:C19H18BrN3O3SPurity:98%Color and Shape:SolidMolecular weight:448.33LTURM-36
CAS:<p>LTURM-36 is a novel inhibitor of PI 3-kinase delta.</p>Formula:C22H18N2O3Purity:98%Color and Shape:SolidMolecular weight:358.39ZDWX-25
CAS:<p>ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>Formula:C17H15N3O3Color and Shape:SolidMolecular weight:309.32MIPS-9922
CAS:<p>MIPS-9922: potent PI3Kβ inhibitor; prevents αIIbβ3 activation, platelet adhesion, and ADP-triggered aggregation.</p>Formula:C28H31F2N9O2Purity:98%Color and Shape:SolidMolecular weight:563.6NSC81111
CAS:<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formula:C19H16O4Color and Shape:SolidMolecular weight:308.33Limertinib
CAS:<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Formula:C29H32ClN7O2Purity:97.44%Color and Shape:SolidMolecular weight:546.06GNE-293
CAS:<p>GNE-293 is a potent and selective PI3Kδ inhibitor.</p>Formula:C28H36N8O4SPurity:98%Color and Shape:SolidMolecular weight:580.7PI-540
CAS:<p>PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).</p>Formula:C22H27N5O2SColor and Shape:SolidMolecular weight:425.55DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Formula:C19H19N9OColor and Shape:SolidMolecular weight:389.41PI3K-IN-6
CAS:<p>PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).</p>Formula:C17H14Cl2FN9OPurity:98%Color and Shape:SolidMolecular weight:450.26PI3Kδ/γ-IN-2
CAS:<p>PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy</p>Formula:C25H21ClN8OColor and Shape:SolidMolecular weight:484.94GLPG3970
CAS:<p>GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.</p>Formula:C25H27F3N4O4Purity:99.60% - >99.99%Color and Shape:SolidMolecular weight:504.5EGFR-IN-68
CAS:<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formula:C24H22N2OColor and Shape:SolidMolecular weight:354.44EAI001
CAS:<p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>Formula:C19H15N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:349.41PI3Kγ inhibitor 4
CAS:<p>PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM).</p>Formula:C20H24N4O4SColor and Shape:SolidMolecular weight:416.49Nimotuzumab
CAS:<p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>Purity:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Color and Shape:LiquidMRT80
CAS:<p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>Formula:C15H15N5OPurity:98%Color and Shape:SolidMolecular weight:281.31mTOR inhibitor-2
CAS:<p>mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).</p>Formula:C23H21N7OPurity:98%Color and Shape:SolidMolecular weight:411.46SDZ281-977
CAS:<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Formula:C18H20O5Purity:99.64%Color and Shape:SolidMolecular weight:316.35(E/Z)-CP-724714
CAS:<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Formula:C27H27N5O3Purity:98%Color and Shape:SolidMolecular weight:469.54AG-183
CAS:<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formula:C13H8N4O3Color and Shape:Brown SolidMolecular weight:268.23PI3Kα-IN-13
CAS:<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Formula:C21H19N5O3Purity:98%Color and Shape:SolidMolecular weight:389.41Nemiralisib
CAS:<p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>Formula:C26H28N6OPurity:99.91%Color and Shape:SolidMolecular weight:440.54PI4KIII β inhibitor 3
CAS:<p>PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).</p>Formula:C22H22N8OSPurity:98%Color and Shape:SolidMolecular weight:446.53TGX-155
CAS:<p>TGX-155 is a selective PI3K inhibitor.</p>Formula:C20H19FN2O3Purity:98%Color and Shape:SolidMolecular weight:354.37FT-1518
CAS:<p>FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.</p>Formula:C20H26N8OPurity:98.34% - 98.80%Color and Shape:SolidMolecular weight:394.47Tarlox-TKI
CAS:<p>Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.</p>Formula:C19H18BrClN6OPurity:97.03%Color and Shape:SolidMolecular weight:461.74AZD3458
CAS:<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Formula:C20H23N3O4S2Color and Shape:SolidMolecular weight:433.54RV-1729
CAS:<p>RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.</p>Formula:C39H39ClN8O5Color and Shape:SolidMolecular weight:735.23BKI-1369
CAS:<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51RTC-5
CAS:<p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>Formula:C24H22ClF3N2O3SPurity:98.14%Color and Shape:SolidMolecular weight:510.96CAL-130 Hydrochloride
CAS:<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H23ClN8OColor and Shape:SolidMolecular weight:462.94EGFR-IN-50
CAS:<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formula:C24H26BrN3O4S2Color and Shape:SolidMolecular weight:564.51NSC114126
CAS:<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formula:C22H20O4Color and Shape:SolidMolecular weight:348.39JBJ-04-125-02
CAS:<p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>Formula:C29H26FN5O3SPurity:98%Color and Shape:SolidMolecular weight:543.61PIKfyve-IN-2
CAS:<p>PIKfyve-IN-2 is a potent inhibitor of the PIKfyve kinase, with potential applications in cancer and autoimmune disorder research [1].</p>Formula:C22H22N8OColor and Shape:SolidMolecular weight:414.46BRD3731
CAS:<p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>Formula:C24H31N3OColor and Shape:SolidMolecular weight:377.523F8
CAS:<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formula:C15H14N2O4Purity:98.14% - 98.25%Color and Shape:SolidMolecular weight:286.28Epertinib
CAS:<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Formula:C30H27ClFN5O3Purity:98%Color and Shape:SolidMolecular weight:560.02EGFR-IN-64
CAS:<p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>Formula:C20H21N3O3Color and Shape:SolidMolecular weight:351.4(R)-PS210
CAS:<p>(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).</p>Formula:C19H15F3O5Color and Shape:SolidMolecular weight:380.31GW 583340 dihydrochloride
CAS:<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Formula:C28H27Cl3FN5O3S2Purity:98.80%Color and Shape:SolidMolecular weight:671.03FD2056
CAS:<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formula:C23H17ClN6O2SPurity:98%Color and Shape:SolidMolecular weight:476.94EGFR-IN-89
CAS:<p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>Formula:C26H31FN8O2SPurity:98%Color and Shape:SolidMolecular weight:538.64AMPK activator 12
CAS:<p>AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.</p>Formula:C23H24BrNO2Purity:99.55%Color and Shape:SolidMolecular weight:426.35PI5P4Ks-IN-1
CAS:<p>PI5P4Ks-IN-1 (compound 7) is an active compound which engages PI5P4Kγ[1].</p>Formula:C20H17N3SColor and Shape:SolidMolecular weight:331.43Antiproliferative agent-34
CAS:<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Formula:C27H27N7O5Purity:98%Color and Shape:SolidMolecular weight:529.55PIMPC
CAS:<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formula:C21H19N5OPurity:98%Color and Shape:SolidMolecular weight:357.41PI3Kγ inhibitor 7
CAS:<p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>Formula:C31H25N9O2Purity:98%Color and Shape:SolidMolecular weight:555.59
