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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • Tyrphostin B44, (+) enantiomer
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    Tyrphostin B44, (+) enantiomer

    CAS:
    <p>Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)</p>
    Formula:C18H16N2O3
    Purity:97.18%
    Color and Shape:Solid
    Molecular weight:308.33

    Ref: TM-T22450

  • CC-115 hydrochloride
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    CC-115 hydrochloride

    CAS:
    <p>CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.</p>
    Formula:C16H17ClN8O
    Color and Shape:Solid
    Molecular weight:372.82

    Ref: TM-T61505

  • GSK2334470
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    GSK2334470

    CAS:
    <p>GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.</p>
    Formula:C25H34N8O
    Purity:99.57% - 99.87%
    Color and Shape:Solid
    Molecular weight:462.59

    Ref: TM-T2348

  • GNE-317
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    GNE-317

    CAS:
    <p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>
    Formula:C19H22N6O3S
    Purity:98.42% - 99.54%
    Color and Shape:Solid
    Molecular weight:414.48

    Ref: TM-T6845

  • Autogramin-1
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    Autogramin-1

    CAS:
    <p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>
    Formula:C23H27N5O5S
    Purity:97.69% - 99.25%
    Color and Shape:Solid
    Molecular weight:485.56

    Ref: TM-T10413

  • RSVA405
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    RSVA405

    CAS:
    <p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>
    Formula:C17H20N4O2
    Purity:99.30%
    Color and Shape:Solid
    Molecular weight:312.37

    Ref: TM-T8476

  • TGX-221
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    TGX-221

    CAS:
    <p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>
    Formula:C21H24N4O2
    Purity:99.68% - >99.99%
    Color and Shape:Solid
    Molecular weight:364.44

    Ref: TM-T2661

  • AG-1557 hydrochloride (189290-58-2(free base))
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    AG-1557 hydrochloride (189290-58-2(free base))

    <p>AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>
    Formula:C16H15ClIN3O2
    Purity:98.64%
    Color and Shape:Solid
    Molecular weight:443.66

    Ref: TM-T4694

  • IM-12
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    IM-12

    CAS:
    <p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>
    Formula:C22H20FN3O2
    Purity:99.42% - >99.99%
    Color and Shape:Solid
    Molecular weight:377.41

    Ref: TM-T2261

  • Trastuzumab
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    Trastuzumab

    CAS:
    <p>Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.</p>
    Purity:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%
    Color and Shape:Liquid
    Molecular weight:Approximately 145.53 kDa

    Ref: TM-T9912

  • MOTS-c(Human) Acetate(1627580-64-6 free)
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    MOTS-c(Human) Acetate(1627580-64-6 free)

    <p>MOTS-c(Human) Acetate is a mitochondrial-derived peptide.</p>
    Formula:C103H156N28O24S2
    Purity:100%
    Color and Shape:Solid
    Molecular weight:2234.64

    Ref: TM-TP2312

  • AZD 6482
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    AZD 6482

    CAS:
    <p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values ​​of 0.69nM and 10nM.Cost-effective and quality-assured.</p>
    Formula:C22H24N4O4
    Purity:99.79% - 99.95%
    Color and Shape:Solid
    Molecular weight:408.45

    Ref: TM-T6087

  • BI-4020
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    BI-4020

    CAS:
    <p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>
    Formula:C30H38N8O2
    Purity:97.21% - >99.99%
    Color and Shape:Solid
    Molecular weight:542.68

    Ref: TM-T10534

  • AEE788
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    AEE788

    CAS:
    <p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>
    Formula:C27H32N6
    Purity:98% - >99.99%
    Color and Shape:Solid
    Molecular weight:440.58

    Ref: TM-T2116

  • VS-5584
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    VS-5584

    CAS:
    <p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>
    Formula:C17H22N8O
    Purity:97.82% - 99.54%
    Color and Shape:Solid
    Molecular weight:354.41

    Ref: TM-T6103

  • (S)-Sunvozertinib
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    (S)-Sunvozertinib

    CAS:
    <p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>
    Formula:C29H35ClFN7O3
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:584.08

    Ref: TM-T9304

  • KU-0063794
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    KU-0063794

    CAS:
    <p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>
    Formula:C25H31N5O4
    Purity:98.21% - >99.99%
    Color and Shape:Solid
    Molecular weight:465.54

    Ref: TM-T2475

  • GS87
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    GS87

    CAS:
    <p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>
    Formula:C16H11N5O2S
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:337.36

    Ref: TM-T8605

  • Voxtalisib
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    Voxtalisib

    CAS:
    <p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>
    Formula:C13H14N6O
    Purity:98.21% - 99.69%
    Color and Shape:Solid
    Molecular weight:270.29

    Ref: TM-T7014

  • GNF4877
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    GNF4877

    CAS:
    <p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>
    Formula:C25H27FN6O4
    Purity:98.68% - 99.40%
    Color and Shape:Solid
    Molecular weight:494.52

    Ref: TM-T11447