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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • Alpelisib hydrochloride
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    Alpelisib hydrochloride

    CAS:
    <p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>
    Formula:C19H23ClF3N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:477.93

    Ref: TM-T14191

  • PI3Kδ-IN-1
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    PI3Kδ-IN-1

    CAS:
    <p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>
    Formula:C22H20F3N7O2
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:471.44

    Ref: TM-T12462

  • EGFR-IN-29
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    EGFR-IN-29

    CAS:
    <p>EGFR-IN-29 is a potent EGFR inhibitor.</p>
    Formula:C36H46BrN8O2P
    Color and Shape:Solid
    Molecular weight:733.68

    Ref: TM-T73106

  • 5-Iodo-indirubin-3'-monoxime
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    5-Iodo-indirubin-3'-monoxime

    CAS:
    <p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>
    Formula:C16H10IN3O2
    Color and Shape:Solid
    Molecular weight:403.17

    Ref: TM-T10172

  • Ampkinone
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    Ampkinone

    CAS:
    <p>Ampkinone is an indirect AMPK activator.</p>
    Formula:C31H23NO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:505.52

    Ref: TM-T10312

  • BPIQ-I
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    BPIQ-I

    CAS:
    <p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>
    Formula:C16H12BrN5
    Color and Shape:Solid
    Molecular weight:354.2

    Ref: TM-T70227

  • LDHA/PDKs-IN-2
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    LDHA/PDKs-IN-2

    CAS:
    <p>Compound 20k is a dual LDHA/PDKs inhibitor; IC50: 0.7/1.6 μM. It boosts O2 use, cuts lactate, and slows A549 cancer cell growth (EC50: 15.7 μM).</p>
    Formula:C17H20N2O5
    Color and Shape:Solid
    Molecular weight:332.35

    Ref: TM-T60995

  • PI3K/mTOR Inhibitor-6
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    PI3K/mTOR Inhibitor-6

    CAS:
    <p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>
    Formula:C30H34N10O4
    Color and Shape:Solid
    Molecular weight:598.66

    Ref: TM-T64219

  • NVP-QAV-572
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    NVP-QAV-572

    CAS:
    <p>NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).</p>
    Formula:C17H19F2N7O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:471.5

    Ref: TM-T12275

  • Lifirafenib
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Formula:C25H17F3N4O3
    Purity:98% - 98.25%
    Color and Shape:Solid
    Molecular weight:478.42

    Ref: TM-T22272

  • SAR502250
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    SAR502250

    CAS:
    <p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>
    Formula:C19H18FN5O2
    Color and Shape:Solid
    Molecular weight:367.38

    Ref: TM-T35560

  • HER2-IN-5
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Formula:C27H33N7O3
    Color and Shape:Solid
    Molecular weight:503.6

    Ref: TM-T63432

  • CC214-1
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    CC214-1

    CAS:
    <p>CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.</p>
    Formula:C20H21N7O2
    Purity:97.16%
    Color and Shape:Solid
    Molecular weight:391.43

    Ref: TM-T9314

  • Antitrypanosomal agent 14
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    Antitrypanosomal agent 14

    CAS:
    <p>Antitrypanosomal agent 14 (Compound 1), a potent T.</p>
    Formula:C14H23N3OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.42

    Ref: TM-T79254

  • A 1070722
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    A 1070722

    CAS:
    <p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>
    Formula:C17H13F3N4O2
    Purity:99.9%
    Color and Shape:Solid
    Molecular weight:362.31

    Ref: TM-T10202

  • PT-65
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    PT-65

    CAS:
    <p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>
    Formula:C51H63N13O12S
    Color and Shape:Solid
    Molecular weight:1082.19

    Ref: TM-T84913

  • PI5P4Kα-IN-1
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    PI5P4Kα-IN-1

    CAS:
    <p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>
    Formula:C20H17N3O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:363.43

    Ref: TM-T78178

  • PI3K/mTOR Inhibitor-5
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    PI3K/mTOR Inhibitor-5

    CAS:
    <p>PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.</p>
    Formula:C32H40N10O3
    Color and Shape:Solid
    Molecular weight:612.73

    Ref: TM-T72408

  • Nazartinib S-enantiomer
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    Nazartinib S-enantiomer

    CAS:
    <p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>
    Formula:C26H31ClN6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:495.02

    Ref: TM-T11156

  • PI3Kγ inhibitor 2
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    PI3Kγ inhibitor 2

    CAS:
    <p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>
    Formula:C20H18F3N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.38

    Ref: TM-T12465