PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(158 products)
- ATM/ATR(71 products)
- DNA-PK(51 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(242 products)
- S6 Kinase(9 products)
- gsk-3(112 products)
- mTOR(144 products)
Show 2 more subcategories
Found 1038 products of "PI3K/Akt/mTOR Signaling"
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PI5P4K-β-IN-1
CAS:<p>PI5P4K-β-IN-1 (compound vs1) is a potent PI5P4K-β inhibitor with an IC50 of 0.80 μM [1].</p>Formula:C23H17Cl2N3O2Color and Shape:SolidMolecular weight:438.31BGB-102
CAS:<p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>Formula:C22H25BrN4O2Purity:99.02%Color and Shape:SolidMolecular weight:457.36Tenalisib R Enantiomer
CAS:<p>Tenalisib R Enantiomer is an R enantiomer of Tenalisib .</p>Formula:C23H18FN5O2Purity:98%Color and Shape:SolidMolecular weight:415.42JND3229
CAS:<p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>Formula:C33H41ClN8O2Purity:98.75%Color and Shape:SolidMolecular weight:617.18mTOR inhibitor-11
CAS:<p>mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.</p>Formula:C21H26N6O2Purity:98%Color and Shape:SolidMolecular weight:394.47DNA-PK-IN-10
CAS:<p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>Formula:C25H28N6O2Purity:98%Color and Shape:SolidMolecular weight:444.53BRD5648
CAS:<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formula:C20H23N3OPurity:99.89%Color and Shape:SolidMolecular weight:321.42GNE-490
CAS:<p>GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.</p>Formula:C18H22N6O2SPurity:99.77%Color and Shape:SolidMolecular weight:386.47TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51LDHA/PDKs-IN-1
CAS:<p>Compound 20e inhibits PDKs (IC50: 0.8 μM) & LDHA (IC50: 0.15 μM), halts A549 cell growth, lowers lactate, boosts oxygen use.</p>Formula:C19H21FN2O4Color and Shape:SolidMolecular weight:360.38(Rac)-BRD0705
CAS:<p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>Formula:C20H23N3OPurity:99.7%Color and Shape:SolidMolecular weight:321.42MS 154
CAS:<p>MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.</p>Formula:C46H54ClFN8O8Color and Shape:SolidMolecular weight:901.42WYE-23
CAS:<p>WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).</p>Formula:C26H32N8O4Color and Shape:SolidMolecular weight:520.58T-00127_HEV1
CAS:<p>T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).</p>Formula:C22H29N5O3Purity:99.89%Color and Shape:SolidMolecular weight:411.5mTOR inhibitor 9d
CAS:<p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>Formula:C21H23N5O3SPurity:99.08%Color and Shape:SoildMolecular weight:425.517β-Hydroxywortmannin
CAS:<p>17β-Hydroxywortmannin is an orally active phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor, exhibiting an IC50 of 0.5 nM and notably suppresses osteoclast resorption at an IC50 of 10 nM. Additionally, it demonstrates antitumor activity.</p>Formula:C23H26O8Color and Shape:SolidMolecular weight:430.45EGFR-IN-74
<p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>Formula:C32H28BrF3N6O4SColor and Shape:SolidMolecular weight:729.57mTOR inhibitor 9b
CAS:<p>mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR</p>Formula:C21H23N5O2SPurity:99.52%Color and Shape:SoildMolecular weight:409.5Dezapelisib
CAS:<p>Dezapelisib, an oral delta PI3K inhibitor, blocks PIP3 production and PI3K/AKT pathway, hindering tumor cell growth and survival.</p>Formula:C20H16FN7OSColor and Shape:SolidMolecular weight:421.45Labuxtinib
CAS:<p>Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].</p>Formula:C20H16FN5O2Purity:99.77%Color and Shape:SolidMolecular weight:377.37SU-11752
CAS:<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Formula:C26H27N3O5SColor and Shape:SolidMolecular weight:493.57PAT-505
CAS:<p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>Formula:C23H18ClF2N3O2SPurity:98.84%Color and Shape:SolidMolecular weight:473.92BMS-599626 Hydrochloride
CAS:<p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>Formula:C27H28ClFN8O3Purity:99.98%Color and Shape:SolidMolecular weight:567.01ZLN024
CAS:<p>ZLN024 is an activator of AMPK allosteric.</p>Formula:C13H13BrN2OSPurity:99.751%Color and Shape:SolidMolecular weight:325.22PI3K/mTOR Inhibitor-1
CAS:<p>PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)</p>Formula:C18H22FN5O3SPurity:98%Color and Shape:SolidMolecular weight:407.46CAL-130 Racemate
CAS:<p>CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47HKI-357
CAS:<p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>Formula:C31H29ClFN5O3Purity:99.91%Color and Shape:SolidMolecular weight:574.05PF-06459988
CAS:<p>PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.</p>Formula:C19H22ClN7O3Purity:98%Color and Shape:SolidMolecular weight:431.88mTOR inhibitor-3
CAS:<p>mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.</p>Formula:C25H30N8O2Purity:99% - 99.64%Color and Shape:SolidMolecular weight:474.56Zandelisib
CAS:<p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>Formula:C31H38F2N8OPurity:99.88%Color and Shape:SolidMolecular weight:576.68Alpelisib hydrochloride
CAS:<p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>Formula:C19H23ClF3N5O2SPurity:98%Color and Shape:SolidMolecular weight:477.93PI3Kδ-IN-1
CAS:<p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>Formula:C22H20F3N7O2Purity:99.85%Color and Shape:SolidMolecular weight:471.44EGFR-IN-29
CAS:<p>EGFR-IN-29 is a potent EGFR inhibitor.</p>Formula:C36H46BrN8O2PColor and Shape:SolidMolecular weight:733.685-Iodo-indirubin-3'-monoxime
CAS:<p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>Formula:C16H10IN3O2Color and Shape:SolidMolecular weight:403.17Ampkinone
CAS:<p>Ampkinone is an indirect AMPK activator.</p>Formula:C31H23NO6Purity:98%Color and Shape:SolidMolecular weight:505.52BPIQ-I
CAS:<p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>Formula:C16H12BrN5Color and Shape:SolidMolecular weight:354.2LDHA/PDKs-IN-2
CAS:<p>Compound 20k is a dual LDHA/PDKs inhibitor; IC50: 0.7/1.6 μM. It boosts O2 use, cuts lactate, and slows A549 cancer cell growth (EC50: 15.7 μM).</p>Formula:C17H20N2O5Color and Shape:SolidMolecular weight:332.35PI3K/mTOR Inhibitor-6
CAS:<p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>Formula:C30H34N10O4Color and Shape:SolidMolecular weight:598.66NVP-QAV-572
CAS:<p>NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).</p>Formula:C17H19F2N7O3S2Purity:98%Color and Shape:SolidMolecular weight:471.5Lifirafenib
CAS:<p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>Formula:C25H17F3N4O3Purity:98% - 98.25%Color and Shape:SolidMolecular weight:478.42SAR502250
CAS:<p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>Formula:C19H18FN5O2Color and Shape:SolidMolecular weight:367.38HER2-IN-5
CAS:<p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>Formula:C27H33N7O3Color and Shape:SolidMolecular weight:503.6CC214-1
CAS:<p>CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.</p>Formula:C20H21N7O2Purity:97.16%Color and Shape:SolidMolecular weight:391.43Antitrypanosomal agent 14
CAS:<p>Antitrypanosomal agent 14 (Compound 1), a potent T.</p>Formula:C14H23N3OSPurity:98%Color and Shape:SolidMolecular weight:281.42A 1070722
CAS:<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formula:C17H13F3N4O2Purity:99.9%Color and Shape:SolidMolecular weight:362.31PT-65
CAS:<p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>Formula:C51H63N13O12SColor and Shape:SolidMolecular weight:1082.19PI5P4Kα-IN-1
CAS:<p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>Formula:C20H17N3O2SPurity:98%Color and Shape:SolidMolecular weight:363.43PI3K/mTOR Inhibitor-5
CAS:<p>PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.</p>Formula:C32H40N10O3Color and Shape:SolidMolecular weight:612.73Nazartinib S-enantiomer
CAS:<p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>Formula:C26H31ClN6O2Purity:98%Color and Shape:SolidMolecular weight:495.02PI3Kγ inhibitor 2
CAS:<p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>Formula:C20H18F3N5O3Purity:98%Color and Shape:SolidMolecular weight:433.38
