S6 Kinase

Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).

MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of …

BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, …

FMK is an irreversible inhibitor of RSK2 kinase.

CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free …

Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the …

MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus …

GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and …

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, …

AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.

Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found …

LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).

AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential …

A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within …

Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.

Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular …

CKI-7 2HCl is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 …

LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 …

Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its …

AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 …

Lenaldekar inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 …

H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: …

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 …

Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related …

CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in …

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is …

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, …

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 …

Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the …

Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant …

LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).

S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.

BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for …

PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with …

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of …