AMPK
AMPK inhibitors are compounds that target and inhibit AMP-Activated Protein Kinase (AMPK), an enzyme that plays a critical role in cellular energy homeostasis. AMPK is activated in response to low energy levels in cells and helps regulate processes such as glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Inhibiting AMPK is important for studying its role in metabolic diseases, cancer, and aging. At CymitQuimica, we offer a range of AMPK inhibitors to support your research in metabolism, oncology, and age-related diseases.
Found 158 products of "AMPK"
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7-Methoxyisoflavone
CAS:<p>7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).</p>Formula:C16H12O3Purity:99.93% - 99.94%Color and Shape:SolidMolecular weight:252.26Methyl cinnamate
CAS:<p>Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.</p>Formula:C10H10O2Purity:99.88%Color and Shape:Colorless To Pale Yellow Solid CrystallineMolecular weight:162.19Cimiracemoside C
CAS:<p>Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.</p>Formula:C35H56O9Purity:99.95%Color and Shape:SolidMolecular weight:620.81Karanjin
CAS:<p>Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.</p>Formula:C18H12O4Purity:99.01%Color and Shape:SolidMolecular weight:292.298-Chloroadenosine
CAS:<p>8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.</p>Formula:C10H12ClN5O4Purity:98.75% - 99.84%Color and Shape:SolidMolecular weight:301.69EX229
CAS:<p>EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.</p>Formula:C24H18ClN3O3Purity:99.20% - 99.36%Color and Shape:SolidMolecular weight:431.87A-769662
CAS:<p>A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).</p>Formula:C20H12N2O3SPurity:97.52% - 99.58%Color and Shape:SolidMolecular weight:360.39RGX-202
CAS:<p>RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.</p>Formula:C4H9N3O2Purity:99.67% - 99.8%Color and Shape:SolidMolecular weight:131.13Chromium(III) acetate
CAS:<p>Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.</p>Formula:C2H3O2CrPurity:99.9%Color and Shape:Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InMolecular weight:76.37Doxorubicin
CAS:<p>Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.</p>Formula:C27H29NO11Purity:99.31%Color and Shape:Red Crystalline Solid SolidMolecular weight:543.52Asteltoxin
CAS:<p>Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.</p>Formula:C23H30O7Color and Shape:SolidMolecular weight:418.486AD1058
CAS:<p>AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.</p>Formula:C19H20N6O3SPurity:98.24%Color and Shape:SolidMolecular weight:412.47TMPA
CAS:<p>TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.</p>Formula:C21H32O6Purity:99.21%Color and Shape:SolidMolecular weight:380.48PF-739
CAS:<p>PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.</p>Formula:C23H23ClN2O5Purity:98%Color and Shape:SolidMolecular weight:442.89AMPK activator 9
CAS:<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Formula:C31H28F4N4O4Color and Shape:SolidMolecular weight:596.57ML753286
CAS:<p>ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.</p>Formula:C20H25N3O3Purity:98%Color and Shape:SolidMolecular weight:355.43XMD-17-51
CAS:<p>XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.</p>Formula:C21H24N8OPurity:99.04%Color and Shape:SoildMolecular weight:404.47AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Formula:C25H21ClN2O6Color and Shape:SolidMolecular weight:480.9AMDE-1
CAS:<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Formula:C18H8ClF6N3Purity:90%Color and Shape:SolidMolecular weight:415.72AMPK activator 6
CAS:<p>AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.</p>Formula:C25H28O5Color and Shape:SolidMolecular weight:408.49AMPK activator 12
CAS:<p>AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.</p>Formula:C23H24BrNO2Purity:99.55%Color and Shape:SolidMolecular weight:426.35OSU-53
CAS:<p>OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.</p>Formula:C25H24F3N3O6S2Color and Shape:SolidMolecular weight:583.6AMPK activator
CAS:<p>AMPK activator</p>Formula:C22H21FO4Purity:98%Color and Shape:SolidMolecular weight:368.4AMPK activator 1
CAS:<p>AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).</p>Formula:C32H33F3N4O3Purity:98%Color and Shape:SolidMolecular weight:578.62HL271
CAS:<p>HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.</p>Formula:C13H17ClF3N5OPurity:98%Color and Shape:SolidMolecular weight:351.76MARK-IN-4
CAS:<p>MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.</p>Formula:C21H23N7OSColor and Shape:SolidMolecular weight:421.52IND 1316
CAS:<p>IND 1316 is an activator of AMP-activated protein kinase (AMPK).</p>Formula:C22H17NO3Color and Shape:SolidMolecular weight:343.38AMPK activator 4
CAS:<p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>Formula:C24H21ClN2O3Purity:99.46% - 99.65%Color and Shape:SolidMolecular weight:420.89ULK1-IN-2
CAS:<p>ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.</p>Formula:C19H16BrFN4O6Purity:99.25% - 99.25%Color and Shape:SolidMolecular weight:495.26YM-53601 free base
CAS:<p>YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.</p>Formula:C21H21FN2OPurity:98%Color and Shape:SolidMolecular weight:336.4AMPK activator 11
CAS:<p>AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-</p>Formula:C25H20N4O2Purity:98%Color and Shape:SolidMolecular weight:408.45LRRK2/NUAK1/TYK2-IN-1
CAS:<p>LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.</p>Formula:C20H11F3N6Color and Shape:SolidMolecular weight:392.34Galegine hydrochloride
CAS:<p>Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.</p>Formula:C6H14ClN3Color and Shape:SolidMolecular weight:163.65GL-V9
CAS:<p>GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.</p>Formula:C24H27NO5Color and Shape:SolidMolecular weight:409.47SMTIN-T140
CAS:<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Formula:C36H34BrClFN5OPPurity:98%Color and Shape:SolidMolecular weight:718.02DK419
CAS:<p>DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.</p>Formula:C16H8ClF6N3OPurity:99.63%Color and Shape:SolidMolecular weight:407.7YLF-466D
CAS:<p>YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.</p>Formula:C29H20ClNO3Purity:97.74%Color and Shape:SolidMolecular weight:465.93PF-249
CAS:<p>PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.</p>Formula:C17H16ClN3O3Purity:97.01%Color and Shape:SolidMolecular weight:345.78Butylate
CAS:<p>Butylate is a herbicide of thiocarbamate.</p>Formula:C11H23NOSColor and Shape:Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoistureMolecular weight:217.37MRT199665
CAS:<p>MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.</p>Formula:C28H31N5O2Color and Shape:SolidMolecular weight:469.58Ampkinone
CAS:<p>Ampkinone is an indirect AMPK activator.</p>Formula:C31H23NO6Purity:98%Color and Shape:SolidMolecular weight:505.52MARK-IN-1
CAS:<p>MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).</p>Formula:C22H23F2N7OSPurity:98%Color and Shape:SolidMolecular weight:471.53MARK-IN-2
CAS:<p>MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).</p>Formula:C18H18ClF2N5OSPurity:98%Color and Shape:SolidMolecular weight:425.8810Z-Hymenialdisine
CAS:<p>Pan kinase inhibitor</p>Formula:C11H10BrN5O2Purity:98%Color and Shape:Light Yellow SolidMolecular weight:324.13PF-06679142
CAS:<p>PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.</p>Formula:C20H17F2NO3Purity:98%Color and Shape:SolidMolecular weight:357.35MK-0626
CAS:<p>MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.</p>Formula:C22H24F2N6O2Purity:99.47% - >99.99%Color and Shape:SolidMolecular weight:442.46AMPK-α1β1γ1 activator 1
CAS:<p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>Formula:C25H24ClNO9Purity:98%Color and Shape:SolidMolecular weight:517.91ZLN024
CAS:<p>ZLN024 is an activator of AMPK allosteric.</p>Formula:C13H13BrN2OSPurity:99.751%Color and Shape:SolidMolecular weight:325.22AMPK activator 7
CAS:<p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>Formula:C23H22F3N3O5Color and Shape:SolidMolecular weight:477.43AMPK-IN-1
CAS:<p>AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.</p>Formula:C24H18ClN3O3Color and Shape:SolidMolecular weight:431.87Demethyleneberberine chloride
CAS:<p>Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-</p>Formula:C19H18ClNO4Purity:98%Color and Shape:SolidMolecular weight:359.8HDAC11-IN-2
CAS:<p>HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.</p>Formula:C25H35N3O3Color and Shape:SolidMolecular weight:425.564Equisetin
CAS:<p>Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.</p>Formula:C22H31NO4Purity:98%Color and Shape:SolidMolecular weight:373.49EGFR-IN-146
CAS:<p>EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.</p>Formula:C20H16N4Color and Shape:SolidMolecular weight:312.368NPC26
CAS:<p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>Formula:C19H23N3O5S2Color and Shape:SolidMolecular weight:437.533Aldometanib
CAS:<p>Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.</p>Formula:C27H43Cl2IN2Purity:99.32% - 99.55%Color and Shape:SolidMolecular weight:593.46XMD-17-51 Trifluoroacetate
CAS:<p>XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.</p>Formula:C23H25F3N8O3Purity:99.65%Color and Shape:SolidMolecular weight:518.49AMPK activator C2
CAS:<p>AMPK activator C2 is an AMPK allosteric activator.</p>Formula:C7H6NO6PPurity:98%Color and Shape:SolidMolecular weight:231.1
