AMPK
AMPK inhibitors are compounds that target and inhibit AMP-Activated Protein Kinase (AMPK), an enzyme that plays a critical role in cellular energy homeostasis. AMPK is activated in response to low energy levels in cells and helps regulate processes such as glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Inhibiting AMPK is important for studying its role in metabolic diseases, cancer, and aging. At CymitQuimica, we offer a range of AMPK inhibitors to support your research in metabolism, oncology, and age-related diseases.
Found 158 products of "AMPK"
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Gomisin J
CAS:<p>Gomisin J is a natural product and have vasodilatory activity.</p>Formula:C22H28O6Purity:99.59% - 99.60%Color and Shape:SolidMolecular weight:388.45Platycodin D
CAS:<p>Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.</p>Formula:C57H92O28Purity:99.2% - 99.65%Color and Shape:SolidMolecular weight:1225.32IMM-H007
CAS:<p>IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression</p>Formula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45O-304
CAS:<p>O-304 is a pan-activator of AMP-activated protein kinase (AMPK).</p>Formula:C16H11Cl2N3O2SPurity:99.84% - ≥98%Color and Shape:SolidMolecular weight:380.25Vaccarin
CAS:<p>Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.</p>Formula:C32H38O19Purity:99.16% - 99.97%Color and Shape:SolidMolecular weight:726.63Demethyleneberberine
CAS:<p>Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either</p>Formula:C19H18NO4Purity:98.08% - 99.18%Color and Shape:SolidMolecular weight:324.35GSK621
CAS:<p>GSK621 is a specific and potent AMPK activator.</p>Formula:C26H20ClN3O5Purity:97.02% - 97.05%Color and Shape:SolidMolecular weight:489.91Metformin
CAS:<p>Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.</p>Formula:C4H11N5Purity:99.77% - >99.99%Color and Shape:SolidMolecular weight:129.16DASA-58
CAS:<p>DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.</p>Formula:C19H23N3O6S2Purity:96.96% - 99.28%Color and Shape:SolidMolecular weight:453.53Trilobatin
CAS:<p>Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially</p>Formula:C21H24O10Purity:97.16%Color and Shape:SolidMolecular weight:436.41ARN-3236
CAS:<p>ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM</p>Formula:C19H16N2O2SPurity:98.89% - 99.7%Color and Shape:SolidMolecular weight:336.41STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formula:C19H10N2O3Purity:97.14% - 98.8%Color and Shape:SolidMolecular weight:314.29WH-4-025
CAS:<p>WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.</p>Formula:C39H38F3N7O5Purity:99.41%Color and Shape:SolidMolecular weight:741.76AMAROGENTIN
CAS:<p>Amarogentin, extracted from Swertia/Gentiana roots, aids liver cancer prevention/treatment by affecting cell cycle and apoptosis.</p>Formula:C29H30O13Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:586.54EB-3D
CAS:<p>EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.</p>Formula:C30H36Br2N4O2Purity:99.48%Color and Shape:SolidMolecular weight:644.4AMPK activator 2
CAS:<p>AMPK activator 2, a chloroformin derivative, may boost cancer treatment by enhancing AMPK and inhibiting mTOR pathways, and cancer cell growth.</p>Formula:C13H18F3N5Purity:99.86%Color and Shape:SolidMolecular weight:301.31BC1618
CAS:<p>BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.</p>Formula:C24H24F3NO2Purity:99.95%Color and Shape:SolidMolecular weight:415.45Pyraclostrobin
CAS:<p>Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.</p>Formula:C19H18ClN3O4Purity:99.89%Color and Shape:SolidMolecular weight:387.82Buformin
CAS:<p>Buformin, a biguanide oral antidiabetic, inhibits liver glucose production and improves insulin sensitivity.</p>Formula:C6H15N5Color and Shape:SolidMolecular weight:157.22Ginkgolide C
CAS:<p>Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.</p>Formula:C20H24O11Purity:99.71% - 99.98%Color and Shape:White PowderMolecular weight:440.4MK-3903
CAS:<p>MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).</p>Formula:C27H19ClN2O3Purity:98.63% - 99.75%Color and Shape:SolidMolecular weight:454.9IMT1
CAS:<p>IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.</p>Formula:C21H21NO4Purity:98.07% - 98.14%Color and Shape:SolidMolecular weight:351.4Kahweol
CAS:<p>Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB</p>Formula:C20H26O3Purity:99.26% - 99.86%Color and Shape:Off-White To Yellow SolidMolecular weight:314.42Dorsomorphin dihydrochloride
CAS:<p>Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on</p>Formula:C24H25N5O·2HClPurity:97.74% - 99.89%Color and Shape:SolidMolecular weight:472.41COH-SR4
CAS:<p>COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.</p>Formula:C13H8Cl4N2OPurity:98.96%Color and Shape:SolidMolecular weight:350.03Marein
CAS:<p>Marein prevents PC12 cell damage by protecting mitochondria and activating AMPK, potentially countering diabetic encephalopathy.</p>Formula:C21H22O11Purity:99.12% - 99.84%Color and Shape:SolidMolecular weight:450.39Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Dorsomorphin
CAS:<p>Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.</p>Formula:C24H25N5OPurity:98% - 99.06%Color and Shape:SolidMolecular weight:399.49Bempedoic acid
CAS:<p>Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C.</p>Formula:C19H36O5Purity:99.85% - 99.94%Color and Shape:SolidMolecular weight:344.49Mogroside I E1
CAS:<p>Mogroside I E1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener.</p>Formula:C36H62O9Purity:98.62% - 99.71%Color and Shape:SolidMolecular weight:638.87Teneligliptin hydrobromide
CAS:<p>Teneligliptin hydrobromide: potent, novel DPP-4 inhibitor; inhibits human/rat plasma DPP-4 with ~1 nM IC50.</p>Formula:C22H30N6OSBrHPurity:97.83% - 99.92%Color and Shape:SolidMolecular weight:628.86Flurbiprofen Axetil
CAS:<p>Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.</p>Formula:C19H19FO4Purity:97.58% - 98%Color and Shape:SolidMolecular weight:330.35STF-118804
CAS:<p>STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.</p>Formula:C25H23N3O4SPurity:98.66%Color and Shape:SolidMolecular weight:461.53SBI-0206965
CAS:<p>SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.</p>Formula:C21H21BrN4O5Purity:99.13%Color and Shape:SolidMolecular weight:489.32WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Formula:C25H29ClN6O3Purity:99.65% - >99.99%Color and Shape:SolidMolecular weight:496.99GSK-690693
CAS:<p>GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.</p>Formula:C21H27N7O3Purity:98.07% - 99.77%Color and Shape:SolidMolecular weight:425.48RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37Nepodin
CAS:<p>Nepodin exhibits antimalarial, anti-inflammatory, and antidiabetic effects by inhibiting COX and activating AMPK to stimulate GLUT4.</p>Formula:C13H12O3Purity:98.5% - 99.12%Color and Shape:SolidMolecular weight:216.23PKC-iota inhibitor 1
CAS:<p>PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)</p>Formula:C21H22N6OPurity:98.82%Color and Shape:SolidMolecular weight:374.44ON123300
CAS:<p>ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).</p>Formula:C24H27N7OPurity:99.22% - 99.53%Color and Shape:SolidMolecular weight:429.52[6]-Gingerol
CAS:<p>[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for tumors.</p>Formula:C17H26O4Purity:98% - 99.66%Color and Shape:Light Yellow OilinessMolecular weight:294.39Palmitelaidic Acid
CAS:<p>Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.</p>Formula:C16H30O2Purity:99.76%Color and Shape:SolidMolecular weight:254.41YKL-06-061
CAS:<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Formula:C30H37N7O2Purity:99.52% - 99.79%Color and Shape:SolidMolecular weight:527.66Tizoxanide
CAS:<p>Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.</p>Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25Kudinoside D
CAS:<p>Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.</p>Formula:C47H72O17Purity:99.66% - 99.88%Color and Shape:SolidMolecular weight:909.06Annaosanchun
CAS:<p>Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).</p>Formula:C19H32O3Purity:99.58%Color and Shape:SolidMolecular weight:308.46ASP4132
CAS:<p>ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.</p>Formula:C46H51F3N6O8S2Purity:98.34%Color and Shape:SolidMolecular weight:937.06HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formula:C26H28N8OPurity:98.38% - 99.70%Color and Shape:SolidMolecular weight:468.55Buformin hydrochloride
CAS:<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>Formula:C6H16ClN5Purity:97.83%Color and Shape:SolidMolecular weight:193.68PF-06409577
CAS:<p>PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).</p>Formula:C19H16ClNO3Purity:95.17% - 98.21%Color and Shape:SolidMolecular weight:341.79
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