PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 242 products of "PI3K"
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Copanlisib dihydrochloride
CAS:<p>Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.</p>Formula:C23H30Cl2N8O4Purity:99.05% - 99.16%Color and Shape:SolidMolecular weight:553.44PI4KIIIbeta-IN-9
CAS:<p>PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .</p>Formula:C23H25N3O5S2Purity:97.18%Color and Shape:SolidMolecular weight:487.59Pictilisib dimethanesulfonate
CAS:<p>Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and</p>Formula:C25H35N7O9S4Purity:99.63%Color and Shape:SolidMolecular weight:705.85Thioridazine hydrochloride
CAS:<p>Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4</p>Formula:C21H27ClN2S2Purity:99.55% - 99.957%Color and Shape:White To Off-White SolidMolecular weight:407.04Sophocarpine monohydrate
CAS:<p>Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formula:C15H22N2OPurity:99.55%Color and Shape:SolidMolecular weight:246.35IPI-3063
CAS:<p>IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).</p>Formula:C25H25N7O2Purity:98.00%Color and Shape:SolidMolecular weight:455.51Safingol hydrochloride
CAS:<p>Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.</p>Formula:C18H40ClNO2Purity:99.39% - 99.71%Color and Shape:SoildMolecular weight:337.969Parsaclisib
CAS:<p>Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)</p>Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.88Inavolisib
CAS:<p>Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.</p>Formula:C18H19F2N5O4Purity:97.36% - 99.87%Color and Shape:SolidMolecular weight:407.37Tenalisib
CAS:<p>Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)</p>Formula:C23H18FN5O2Purity:99.71%Color and Shape:SolidMolecular weight:415.42CGS 15943
CAS:<p>CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.</p>Formula:C13H8ClN5OPurity:97.4%Color and Shape:SolidMolecular weight:285.69P110δ-IN-1
CAS:<p>P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).</p>Formula:C31H40N8O3SPurity:99.75%Color and Shape:SolidMolecular weight:604.77NSC781406
CAS:<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formula:C29H27F2N5O5S2Purity:99.58%Color and Shape:SolidMolecular weight:627.68PI4KIIIbeta-IN-10
CAS:<p>PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).</p>Formula:C22H25N3O5S2Purity:99.76%Color and Shape:SolidMolecular weight:475.58Recilisib
CAS:<p>Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.</p>Formula:C16H13ClO4SPurity:98.85% - 98.96%Color and Shape:SolidMolecular weight:336.79FD274
CAS:<p>FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,</p>Formula:C22H14ClFN6O2SPurity:98%Color and Shape:SoildMolecular weight:480.9Duvelisib (R enantiomer) hydrochloride
<p>Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.</p>Formula:C22H18Cl2N6OPurity:99.88% - >99.99%Color and Shape:SoildMolecular weight:453.32PI3K-IN-46
CAS:<p>PI3K-IN-46 is a specific inhibitor of PI3Kγ.</p>Formula:C13H9N3OSPurity:97.51%Color and Shape:SoildMolecular weight:255.3(3S)-GSK-F1
CAS:<p>(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.</p>Formula:C27H18F5N5O4SPurity:99.04%Color and Shape:SoildMolecular weight:603.52PI3Kδ-IN-12
<p>PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4</p>Formula:C20H15Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:444.27IHMT-PI3K-315
<p>IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.</p>Formula:C22H20F2N6O4Color and Shape:SolidMolecular weight:470.43IHMT-PI3Kδ-372 S-isomer
CAS:<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Formula:C26H23F2N7O2Purity:99.97%Color and Shape:SoildMolecular weight:503.5PI3Kγ ligand 1
CAS:<p>PI3Kγ ligand 1 serves as a PROTAC target protein ligand (Ligand for Target Protein for PROTAC).</p>Formula:C26H29N5O3SColor and Shape:SolidMolecular weight:491.61PITCOIN4
<p>PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivity</p>Purity:98%Color and Shape:Odour SolidPI3K-IN-41
<p>PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV light</p>Formula:C45H39F2N5O12SPurity:98%Color and Shape:SolidMolecular weight:911.88mTOR inhibitor 9f
CAS:<p>mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.</p>Formula:C25H23N5O2SPurity:99.18%Color and Shape:SoildMolecular weight:457.55mTOR inhibitor 9e
CAS:<p>mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.</p>Formula:C22H23N5O2SPurity:98.84%Color and Shape:SoildMolecular weight:421.52mTOR inhibitor 13
CAS:<p>Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).</p>Formula:C24H22N6O2SPurity:99.75%Color and Shape:SolidMolecular weight:458.54mTOR inhibitor 9c
CAS:<p>mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.</p>Formula:C21H22FN5O2SPurity:99.23%Color and Shape:SoildMolecular weight:427.5Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Color and Shape:Odour SolidSTX-478
CAS:<p>STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumor</p>Formula:C16H12F5N5O2Purity:98.31% - 99.78%Color and Shape:SolidMolecular weight:401.29PI3Kδ-IN-18
<p>Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].</p>Purity:98%Color and Shape:Odour SolidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Color and Shape:LiquidPI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Color and Shape:Odour SolidGSK251
CAS:<p>GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.</p>Formula:C29H37FN6O4SPurity:99.8%Color and Shape:SolidMolecular weight:584.71PI3Kδ-IN-14
<p>PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of</p>Formula:C26H20ClFN8OPurity:98%Color and Shape:SolidMolecular weight:514.94DA-143
<p>DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.</p>Color and Shape:Odour SolidBAY1082439
CAS:<p>BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].</p>Formula:C25H30N6O5Purity:100%Color and Shape:SolidMolecular weight:494.54D-106669
CAS:<p>D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.</p>Formula:C17H18N6OColor and Shape:SolidMolecular weight:322.36PI5P4Ks-IN-2
CAS:<p>PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.</p>Formula:C22H23N5Purity:98.36% - 99.02%Color and Shape:SoildMolecular weight:357.45PI3Kα-IN-12
<p>PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values</p>Formula:C28H36F2N10O5S3Color and Shape:SolidMolecular weight:726.84PI3Kα-IN-25
<p>PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.</p>Formula:C21H19ClN4O4Color and Shape:SolidMolecular weight:426.853ARUK2001607
CAS:<p>ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.</p>Formula:C14H13N3O2S2Purity:99.75%Color and Shape:SoildMolecular weight:319.40WYE-687
CAS:<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formula:C28H32N8O3Purity:99.93%Color and Shape:SolidMolecular weight:528.61PI3K-IN-57
<p>PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.</p>Color and Shape:Odour SolidPI3K-IN-47
<p>PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)</p>Formula:C50H46F4N8O8S2Purity:98%Color and Shape:SolidMolecular weight:1027.07IHMT-PI3K-455
<p>IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for</p>Formula:C26H21F2N7O3Purity:98%Color and Shape:SolidMolecular weight:517.49Umbralisib R-enantiomer
CAS:<p>Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.</p>Formula:C31H24F3N5O3Purity:97.34%Color and Shape:SolidMolecular weight:571.55GSK2292767 FA
<p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>Formula:C25H30N6O7SPurity:99.52%Color and Shape:SoildMolecular weight:558.61PROTAC PI3K/110β degrader-1
CAS:<p>PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.</p>Formula:C51H65N9O9SColor and Shape:SolidMolecular weight:980.18PF-06843195
CAS:<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Formula:C20H25F3N8O4Purity:98.01%Color and Shape:SolidMolecular weight:498.46AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Formula:C14H8FNO4SPurity:99.06% - 99.09%Color and Shape:SolidMolecular weight:305.28PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formula:C22H27N5O4Purity:96.27% - ≥95%Color and Shape:SolidMolecular weight:425.48Oroxin B
CAS:<p>Oroxin B (Hypocretin-2) has antioxidant activity.</p>Formula:C27H30O15Purity:98.22% - 99.81%Color and Shape:SolidMolecular weight:594.52GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formula:C18H22N8O2Purity:99.72% - 99.87%Color and Shape:SolidMolecular weight:382.42PIK-294
CAS:<p>PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).</p>Formula:C28H23N7O2Purity:97.22% - >99.99%Color and Shape:SolidMolecular weight:489.53PF-4989216
CAS:<p>PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.</p>Formula:C18H13FN6OSPurity:99.85%Color and Shape:SolidMolecular weight:380.41-Deoxynojirimycin
CAS:<p>1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.</p>Formula:C6H13NO4Purity:99.65% - 99.98%Color and Shape:White-Beige Solid CrystallineMolecular weight:163.17MTX-211
CAS:<p>MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.</p>Formula:C20H14Cl2FN5O2SPurity:97.6% - >99.99%Color and Shape:SolidMolecular weight:478.33Esculetin
CAS:<p>Esculetin: a coumarin from plants with anti-edema, anti-inflammatory, anti-tumor properties; inhibits LOs.</p>Formula:C9H6O4Purity:98.03% - 99.76%Color and Shape:Yellow Crystalline PowderMolecular weight:178.14Alpelisib
CAS:<p>Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.</p>Formula:C19H22F3N5O2SPurity:98% - 99.73%Color and Shape:SolidMolecular weight:441.47GSK1059615
CAS:<p>GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.</p>Formula:C18H11N3O2SPurity:99.3% - ≥95%Color and Shape:SolidMolecular weight:333.36Wortmannin
CAS:<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Formula:C23H24O8Purity:95.84% - 99.76%Color and Shape:White SolidMolecular weight:428.433-Methyladenine
CAS:<p>3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).</p>Formula:C6H7N5Purity:98.02% - 99.65%Color and Shape:SolidMolecular weight:149.15PI-103
CAS:<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formula:C19H16N4O3Purity:97.79% - 99.3%Color and Shape:SolidMolecular weight:348.36Erucic acid
CAS:<p>Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).</p>Formula:C22H42O2Purity:99.64%Color and Shape:Needles From Alcohol Liquid OthersolidMolecular weight:338.57Brevianamide F
CAS:<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Formula:C16H17N3O2Purity:97.30% - 98.82%Color and Shape:SolidMolecular weight:283.33PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44LY294002
CAS:<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Formula:C19H17NO3Purity:98% - 99.96%Color and Shape:Pale Yellow SolidMolecular weight:307.34Dihydrocapsaicin
CAS:<p>Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.</p>Formula:C18H29NO3Purity:99.61% - ≥95%Color and Shape:White CrystalMolecular weight:307.43Copanlisib
CAS:<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Formula:C23H28N8O4Purity:99% - 99.88%Color and Shape:SolidMolecular weight:480.52Bimiralisib
CAS:<p>Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.</p>Formula:C17H20F3N7O2Purity:97.58% - 98.92%Color and Shape:SolidMolecular weight:411.38Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Formula:C15H15N7OPurity:99.19% - >99.99%Color and Shape:SolidMolecular weight:309.33Idelalisib
CAS:<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.42Hederacolchiside A1
CAS:<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Formula:C47H76O16Purity:98.76% - 99.92%Color and Shape:SolidMolecular weight:897.1ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formula:C19H21F2N7O2Purity:98.29% - 99.95%Color and Shape:White PowderMolecular weight:417.41Omipalisib
CAS:<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formula:C25H17F2N5O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:505.5Rigosertib
CAS:<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Formula:C21H25NO8SPurity:99.53%Color and Shape:SolidMolecular weight:451.49YS-49
CAS:<p>YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).</p>Formula:C20H20BrNO2Purity:99.65%Color and Shape:SolidMolecular weight:386.28Periplocin
CAS:<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82TGX-221
CAS:<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formula:C21H24N4O2Purity:99.68% - >99.99%Color and Shape:SolidMolecular weight:364.44LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formula:C22H19ClN2O6SPurity:99.45%Color and Shape:SolidMolecular weight:474.91BQR-695
CAS:<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Formula:C19H20N4O3Purity:98.91% - 99.69%Color and Shape:SolidMolecular weight:352.39PI-3065
CAS:<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Formula:C27H31FN6OSPurity:99.84% - ≥95%Color and Shape:SolidMolecular weight:506.64Fimepinostat
CAS:<p>Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.</p>Formula:C23H24N8O4SPurity:98.27% - 99.87%Color and Shape:SolidMolecular weight:508.55TASP0415914
CAS:<p>TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T</p>Formula:C13H17N5O3SPurity:98.14%Color and Shape:SolidMolecular weight:323.37Flavanomarein
CAS:<p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>Formula:C21H22O11Purity:98.63% - 99.54%Color and Shape:SolidMolecular weight:450.39Taurolithocholic acid sodium salt
CAS:<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formula:C26H44NNaO5SPurity:99.79% - 99.93%Color and Shape:SolidMolecular weight:505.69Desmethylglycitein
CAS:<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Formula:C15H10O5Purity:97.93%Color and Shape:SolidMolecular weight:270.24AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.41-Deoxynojirimycin hydrochloride
CAS:<p>1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.</p>Formula:C6H14ClNO4Purity:99.88%Color and Shape:SolidMolecular weight:199.63NIBR-17
CAS:<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.4Glaucocalyxin A
CAS:<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Formula:C20H28O4Purity:99.55% - 99.80%Color and Shape:SolidMolecular weight:332.43PIK-75 hydrochloride
CAS:<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74Apitolisib
CAS:<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Formula:C23H30N8O3SPurity:98.28% - 99.64%Color and Shape:SolidMolecular weight:498.6Flupentixol dihydrochloride
CAS:<p>Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.</p>Formula:C23H27Cl2F3N2OSPurity:98.76% - >99.99%Color and Shape:White Or Off-White SolidMolecular weight:507.43VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formula:C17H22N8OPurity:97.82% - 99.54%Color and Shape:SolidMolecular weight:354.41ETP-46321
CAS:<p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>Formula:C20H27N9O3SPurity:99.8%Color and Shape:SolidMolecular weight:473.55Autophinib
CAS:<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Formula:C14H11ClN6O3Purity:99.25% - 99.41%Color and Shape:SolidMolecular weight:346.73Taselisib
CAS:<p>Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.</p>Formula:C24H28N8O2Purity:99.62% - 99.79%Color and Shape:SolidMolecular weight:460.53IITZ-01
CAS:<p>IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)</p>Formula:C26H23FN8OPurity:99.31%Color and Shape:SolidMolecular weight:482.51Lupiwighteone
CAS:<p>Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.</p>Formula:C20H18O5Purity:98.92%Color and Shape:SolidMolecular weight:338.35Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formula:C28H25F3N6O2Purity:95.74% - 99.51%Color and Shape:SolidMolecular weight:534.53NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formula:C20H14F3N3SPurity:99.84% - 99.9%Color and Shape:SolidMolecular weight:385.41GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44Rigosertib sodium
CAS:<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Formula:C21H24NNaO8SPurity:98% - 99.37%Color and Shape:SolidMolecular weight:473.47SKI V
CAS:<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Formula:C15H10O4Purity:98.78%Color and Shape:SolidMolecular weight:254.24Quercetin
CAS:<p>Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.</p>Formula:C15H10O7Purity:96.29% - 98.05%Color and Shape:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Molecular weight:302.24MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Formula:C18H16N2O2Purity:99.66%Color and Shape:SolidMolecular weight:292.33(+)-Nortrachelogenin
CAS:<p>(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.</p>Formula:C20H22O7Purity:99.88%Color and Shape:SolidMolecular weight:374.38Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formula:C23H26N4O3Purity:98.41% - 99.69%Color and Shape:SolidMolecular weight:406.48Heterophyllin B
CAS:<p>Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.</p>Formula:C40H58N8O8Purity:99.12% - 99.85%Color and Shape:SolidMolecular weight:778.94AMG319
CAS:<p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.</p>Formula:C21H16FN7Purity:98.9% - 99.24%Color and Shape:Crystalline SolidMolecular weight:385.4P7C3-A20
CAS:<p>P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.</p>Formula:C22H19Br2FN2OPurity:96.83% - ≥98%Color and Shape:SolidMolecular weight:506.21Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29Umbralisib
CAS:<p>Umbralisib (TGR 1202) is a PI3Kδ inhibitor.</p>Formula:C31H24F3N5O3Purity:99.56% - 99.56%Color and Shape:White SolidMolecular weight:571.55AZD-8835
CAS:<p>AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).</p>Formula:C22H31N9O3Purity:98.22% - 99.88%Color and Shape:SolidMolecular weight:469.54AS-604850
CAS:<p>AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.</p>Formula:C11H5F2NO4SPurity:99.65%Color and Shape:SolidMolecular weight:285.22PIK-93
CAS:<p>PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.</p>Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88CH5132799
CAS:<p>CH5132799 has been used in trials studying the treatment of Solid Tumors.</p>Formula:C15H19N7O3SPurity:99.41% - 99.87%Color and Shape:SolidMolecular weight:377.42Seletalisib
CAS:<p>Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).</p>Formula:C23H14ClF3N6OPurity:99.81%Color and Shape:SolidMolecular weight:482.85α-Linolenic acid
CAS:<p>α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.</p>Formula:C18H30O2Purity:97.05% - 99.81%Color and Shape:Physical Description Clear Colorless Liquid (Ntp 1992)Molecular weight:278.43GSK2636771
CAS:<p>GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and</p>Formula:C22H22F3N3O3Purity:98.58% - ≥95%Color and Shape:SolidMolecular weight:433.42Vps34-IN-1
CAS:<p>Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.</p>Formula:C21H24ClN7OPurity:97.04%Color and Shape:SolidMolecular weight:425.91SAR405
CAS:<p>SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.</p>Formula:C19H21ClF3N5O2Purity:99.42% - 99.79%Color and Shape:SolidMolecular weight:443.85PIK-90
CAS:<p>PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .</p>Formula:C18H17N5O3Purity:98.25% - ≥95%Color and Shape:SolidMolecular weight:351.36A66
CAS:<p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>Formula:C17H23N5O2S2Purity:99.51% - ≥95%Color and Shape:SolidMolecular weight:393.53Linperlisib
CAS:<p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>Formula:C28H37FN6O5SPurity:99.01%Color and Shape:SolidMolecular weight:588.69Vps34-IN-4
CAS:<p>VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)</p>Formula:C21H25N7OPurity:98.6%Color and Shape:SolidMolecular weight:391.47CAY10505
CAS:<p>CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).</p>Formula:C14H8FNO3SPurity:99.69% - 99.74%Color and Shape:SolidMolecular weight:289.28GDC-0326
CAS:<p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>Formula:C19H22N6O3Purity:99.35% - >99.99%Color and Shape:SolidMolecular weight:382.42AZD8186
CAS:<p>AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).</p>Formula:C24H25F2N3O4Purity:99.89% - 99.91%Color and Shape:SolidMolecular weight:457.47Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Formula:C23H20FN7OPurity:97.96%Color and Shape:SolidMolecular weight:429.45Pilaralisib analogue
CAS:<p>Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.</p>Formula:C21H16N6O2S2Purity:99.3% - 99.72%Color and Shape:SolidMolecular weight:448.52AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Formula:C22H24N4O4Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:408.45PIK-293
CAS:<p>PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.</p>Formula:C22H19N7OPurity:99.88%Color and Shape:SolidMolecular weight:397.43ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Formula:C16H17N5O2Purity:99.14%Color and Shape:SolidMolecular weight:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54Pectolinarin
CAS:<p>Pectolinarin is a Cirsium isolate with anti-inflammatory activity.</p>Formula:C29H34O15Purity:98% - 99.79%Color and Shape:SolidMolecular weight:622.57GNE-317
CAS:<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Formula:C19H22N6O3SPurity:98.42% - 99.54%Color and Shape:SolidMolecular weight:414.48Pictilisib
CAS:<p>Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).</p>Formula:C23H27N7O3S2Purity:98.69% - 99.97%Color and Shape:SolidMolecular weight:513.64Sincalide
CAS:<p>Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.</p>Formula:C49H62N10O16S3Purity:98.32%Color and Shape:SolidMolecular weight:1143.27IC-87114
CAS:<p>IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).</p>Formula:C22H19N7OPurity:99.30% - >99.99%Color and Shape:SolidMolecular weight:397.43Orobol
CAS:<p>Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.</p>Formula:C15H10O6Purity:98% - 98%Color and Shape:SolidMolecular weight:286.24Musk ketone
CAS:<p>Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.</p>Formula:C14H18N2O5Purity:99.85%Color and Shape:Yellow Crystals Physical Description Light Yellow Crystalline Solid Insoluble In Water (Ntp 1992)Molecular weight:294.30AS-041164
CAS:<p>AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.</p>Formula:C11H7NO4SPurity:99.45%Color and Shape:SolidMolecular weight:249.24PQR530
CAS:<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Formula:C18H23F2N7O2Purity:99.5%Color and Shape:SolidMolecular weight:407.42YM-201636
CAS:<p>YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.</p>Formula:C25H21N7O3Purity:93.28% - 98.3%Color and Shape:SolidMolecular weight:467.48Polygalasaponin F
CAS:<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>Formula:C53H86O23Purity:98% - 99.83%Color and Shape:SolidMolecular weight:1091.24Isorhamnetin
CAS:<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Formula:C16H12O7Purity:99.20% - >99.99%Color and Shape:SolidMolecular weight:316.26Pilaralisib
CAS:<p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>Formula:C25H25ClN6O4SPurity:98.51% - 99.61%Color and Shape:SolidMolecular weight:541.02SF2523
CAS:<p>SF2523 is a highly selective and potent inhibitor.</p>Formula:C19H17NO5SPurity:99.1% - 99.51%Color and Shape:SolidMolecular weight:371.41LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81DS-7423
CAS:<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formula:C22H27F3N10O2Purity:99.98%Color and Shape:SolidMolecular weight:520.51Gedatolisib
CAS:<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Formula:C32H41N9O4Purity:98% - 99.36%Color and Shape:SolidMolecular weight:615.73KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Formula:C33H34N4O4SPurity:98.75%Color and Shape:SolidMolecular weight:582.71Desmethyl-VS-5584
CAS:<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Formula:C16H20N8OPurity:>99.99%Color and Shape:SolidMolecular weight:340.38Duvelisib
CAS:<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Formula:C22H17ClN6OPurity:98.87% - 99.74%Color and Shape:SolidMolecular weight:416.86PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formula:C16H14BrN5O4SPurity:98.52% - >99.99%Color and Shape:SolidMolecular weight:452.28Vacuolin-1
CAS:<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formula:C26H24IN7OPurity:97.20% - 98.45%Color and Shape:SolidMolecular weight:577.42CZC24832
CAS:<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Formula:C15H17FN6O2SPurity:99.08% - 99.12%Color and Shape:SolidMolecular weight:364.4Deoxyelephantopin
CAS:<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Formula:C19H20O6Purity:99.6% - 99.71%Color and Shape:SolidMolecular weight:344.36Acalisib
CAS:<p>Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.</p>Formula:C21H16FN7OPurity:98.99% - ≥95%Color and Shape:SolidMolecular weight:401.4Parsaclisib hydrochloride
CAS:<p>Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.</p>Formula:C20H23Cl2FN6O2Purity:98%Color and Shape:SolidMolecular weight:469.34Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formula:C30H24N8O2Purity:99.04% - 99.28%Color and Shape:SolidMolecular weight:528.56AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formula:C22H28FN9O3SPurity:≥98%Color and Shape:SolidMolecular weight:517.58(E)-Akt inhibitor-IV
CAS:<p>(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>Formula:C31H29IN4SPurity:99.74% - 99.9%Color and Shape:SolidMolecular weight:616.56iMDK
CAS:<p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>Formula:C21H13FN2O2SPurity:99.99%Color and Shape:SolidMolecular weight:376.4Vps34-PIK-III
CAS:<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Formula:C17H17N7Purity:98.39% - 98.43%Color and Shape:SolidMolecular weight:319.36GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63TG 100713
CAS:<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Formula:C12H10N6OPurity:98.17%Color and Shape:SolidMolecular weight:254.25BEBT-908
CAS:<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Formula:C23H25N9O3SPurity:99.67%Color and Shape:SolidMolecular weight:507.57PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.661,3-Dicaffeoylquinic acid
CAS:<p>1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.</p>Formula:C25H24O12Purity:98% - 98.81%Color and Shape:SolidMolecular weight:516.45Euscaphic acid
CAS:<p>Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.</p>Formula:C30H48O5Purity:98.93%Color and Shape:SolidMolecular weight:488.7AS-605240
CAS:<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Formula:C12H7N3O2SPurity:97% - 99.91%Color and Shape:SolidMolecular weight:257.27HS-173
CAS:<p>HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).</p>Formula:C21H18N4O4SPurity:99.33% - 99.64%Color and Shape:SolidMolecular weight:422.46Serabelisib
CAS:<p>Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).</p>Formula:C19H17N5O3Purity:98.41% - 99.5%Color and Shape:SolidMolecular weight:363.37TG100-115
CAS:<p>TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.</p>Formula:C18H14N6O2Purity:99.22% - 99.26%Color and Shape:SolidMolecular weight:346.34Sophocarpine
CAS:<p>Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formula:C15H22N2OPurity:99.89%Color and Shape:SolidMolecular weight:246.35Quercetin Dihydrate
CAS:<p>Quercetin Dihydrate (Sophoretin) is a flavonoid natural product that activates or inhibits the activity of many proteins. It activates SIRT1 and inhibits PI3K.</p>Formula:C15H10O7·2H2OPurity:97.77%Color and Shape:Yellow SolidMolecular weight:338.2725(R,S)-Ruscogenin
CAS:<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Formula:C27H42O4Purity:99.32% - 99.89%Color and Shape:SolidMolecular weight:430.62Buparlisib
CAS:<p>Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).</p>Formula:C18H21F3N6O2Purity:95.32% - 98.45%Color and Shape:SolidMolecular weight:410.39RLY-2608
CAS:<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Formula:C29H14ClF5N6O2Purity:98.62% - 98.7%Color and Shape:SolidMolecular weight:608.91740 Y-P
CAS:<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>Formula:C141H222N43O39PS3Purity:98.3% - 99.87%Color and Shape:SolidMolecular weight:3270.7BGT226 maleate
CAS:<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Formula:C28H25F3N6O2·C4H4O4Purity:97.75% - 98.78%Color and Shape:SolidMolecular weight:650.6GSK2292767
CAS:<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Formula:C24H28N6O5SPurity:98%Color and Shape:SolidMolecular weight:512.58CNX-1351
CAS:<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formula:C30H35N7O3SPurity:99.66% - 99.83%Color and Shape:SolidMolecular weight:573.71AZ2
CAS:<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Formula:C20H23N3O2SPurity:99.25%Color and Shape:SolidMolecular weight:369.48Nemiralisib
CAS:<p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>Formula:C26H28N6OPurity:99.91%Color and Shape:SolidMolecular weight:440.54PI3Kγ inhibitor 7
CAS:<p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>Formula:C31H25N9O2Purity:98%Color and Shape:SolidMolecular weight:555.59CAL-130
CAS:<p>CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47FD2056
CAS:<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formula:C23H17ClN6O2SPurity:98%Color and Shape:SolidMolecular weight:476.94PI3K-IN-9
CAS:<p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>Formula:C19H23N7OPurity:98%Color and Shape:SolidMolecular weight:365.43PI3Kdelta inhibitor 1
CAS:<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Formula:C27H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:558.69PI3Kδ-IN-3
CAS:<p>PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.</p>Formula:C28H24N6O3Purity:98.43%Color and Shape:SolidMolecular weight:492.53Vps34-IN-2
CAS:<p>Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).</p>Formula:C18H25F3N4O3Purity:98%Color and Shape:SolidMolecular weight:402.41PI3K/mTOR Inhibitor-2
CAS:<p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>Formula:C20H13ClF2N4O4SPurity:96.16%Color and Shape:SolidMolecular weight:478.86
