Organometallic Ligands

<p>Bromocriptine is a dopamine D2 receptor agonist that is used for the treatment of galactorrhoea which is due to hyperprolactinemia and other prolactin-related conditions. This drug is an ergot alkaloid derivative that inhibits prolactin secretion. Additionally, it can be used to management signs and symptoms of Parkinsonian syndrome. Research has indicated this drug for pulmonary fibrosis as well.</p>

<p>Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.</p>

<p>Inhibitor of chymotrypsin</p>

<p>Inhibitor of glutaminase; glutamine analogue</p>

<p>Histamine (H2) receptor antagonist</p>

<p>Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.</p>

<p>2-adrenoceptor agonist; bronchodilator</p>

<p>A selective and potent inhibitor of phosphodiesterase 2 (PDE2). Raises cAMP and cGMP levels in neurons, improves social recognition and object memory in murine animals. Reverses anxiolytic effects induced by oxidative stress in mice by blocking cGMP-PKG signaling.</p>

<p>Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.</p>

<p>BMH-9 is a peptide inhibitor, which is sourced from natural extracellular matrix components. Its mode of action involves binding specifically to target proteins, thereby inhibiting their interaction with other molecules. This specificity makes it a valuable tool in biochemical and cellular studies designed to elucidate protein functions and pathways.</p>

<p>4,5,6,7-Tetrabromobenzimidazole is a brominated heterocyclic compound, which is synthesized chemically from benzimidazole. Its bromination at the 4, 5, 6, and 7 positions of the benzimidazole ring enhances its reactivity, making it a highly potent inhibitor in various enzymatic processes. This compound is primarily sourced through methods that involve controlled bromination reactions in laboratory settings.</p>

<p>Icatibant is a 10 amino acid peptidomimetic of bradykinin and a selective antagonist to the bradykinin B2 receptor. Icabinant has been used for the treatment of attacks in patients with hereditary angioedema. Recent evidence has shown a link between dysregulated bradykinin‐mediated inflammation and acute respiratory distress syndrome (ARDS), a common complication in COVID-19 patients. Icatibant was proposed to inhibit excessive activation of the bradykinin B2 receptor during the SARS-CoV-2 infection, reducing the risk of ARDS.</p>

<p>S6821 is a synthetic compound classified as a selective inhibitor, which is derived through chemical synthesis processes. The compound functions by targeting specific molecular pathways involved in cellular processes, primarily through inhibition of particular enzymes or signaling proteins. This selective inhibition allows for precise modulation of biochemical pathways, providing insight into cellular mechanisms and disease pathology.</p>

<p>Azocasein is a chromogenic substrate, which is derived from casein, with azo dye linkages. It functions by undergoing hydrolysis in the presence of proteolytic enzymes, resulting in the release of soluble azo dye fragments that can be quantified spectrophotometrically. This mode of action allows for the measurement of protease activity by evaluating the intensity of the color change, typically at an absorbance wavelength of around 350-440 nm.</p>

<p>Forskolin is a compound derived from the medicinal plant Coleus forskohlii. As an activator of adenylate cyclase, Forskolin causes increases cellular levels of cAMP, and can be used in cell physiology research. It also has antihypertensive, platelet aggregation inhibitory and smooth muscle relaxant effects.</p>

<p>Estrogen receptor degrader; therapeutic use in breast cancer</p>

<p>HS-1371 is a selective chemical inhibitor targeting specific enzymes, which is derived from synthetic organic compounds with a high affinity for its target proteins. It functions by selectively binding to the active site of the enzyme, inhibiting its activity and subsequently influencing downstream signaling pathways within the cell. This mode of action allows researchers to dissect complex biochemical pathways and assess the impact of enzyme inhibition on cellular functions.</p>

<p>A potent inhibitor of STING protein (stimulator of interferon genes), a protein that partakes in intracellular DNA sensing pathway.  H 151 blocks palmitoylation of STING, which is required for the formation of multimeric complexes for recruiting downstream signalling molecules. Inhibition of STING by H 151 reduces pro-inflammatory cytokine synthesis.</p>

<p>Inhibitor of serotonin reuptake</p>

<p>Imatinib is a tyrosine kinase inhibitor that is used in the treatment of various leukemias and gastrointestinal stromal tumors. This drug inhibits the BCR-ABL tyrosine kinase. It is suggested that Imatinib also inhibits other tyrosine kinases such as PDGF, SCF and c-Kit.</p>