Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1382 products of "Cytoskeletal Signaling"
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Tasidotin hydrochloride
CAS:<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Formula:C32H59ClN6O5Purity:98%Color and Shape:SolidMolecular weight:643.30Icafolin-methyl
CAS:<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Formula:C18H18F2N2O5Color and Shape:SolidMolecular weight:380.34316,16-Dimethyl prostaglandin E2
CAS:<p>16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.</p>Formula:C22H36O5Purity:98%Color and Shape:SolidMolecular weight:380.52AS2521780
CAS:<p>AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).</p>Formula:C30H41N7OSPurity:98%Color and Shape:SolidMolecular weight:547.76GSK3β-IN-2
CAS:<p>GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.</p>Formula:C25H18N4OColor and Shape:SolidMolecular weight:390.437PM-060184
CAS:<p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>Formula:C31H45N3O7Purity:98%Color and Shape:SolidMolecular weight:571.7Alfalone
CAS:<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Formula:C17H14O5Color and Shape:SolidMolecular weight:298.29Monomethyl auristatin E intermediate-17
CAS:<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Formula:C27H35NO7SMolecular weight:517.63NRX-103094
CAS:<p>NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.</p>Formula:C20H11Cl2F3N2O4SPurity:99.13%Color and Shape:SolidMolecular weight:503.28NRX-252114
CAS:<p>NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).</p>Formula:C22H12Cl2F3N3O2SPurity:99.70%Color and Shape:SolidMolecular weight:510.32AKT Kinase Inhibitor
CAS:<p>AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.</p>Formula:C16H19N7O3Purity:97.83% - 99.13%Color and Shape:SolidMolecular weight:357.37Ombrabulin
CAS:<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.44ZW4864
CAS:<p>ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.</p>Formula:C33H43ClN6O3Color and Shape:SolidMolecular weight:607.224-Methylenecycloartanyl ferulate
CAS:<p>24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.</p>Formula:C41H60O4Color and Shape:SolidMolecular weight:616.927Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51Tau tracer 2
CAS:<p>Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].</p>Formula:C15H9FN4Color and Shape:SolidMolecular weight:264.26320-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formula:C20H32O3Purity:99.79%Color and Shape:SolidMolecular weight:320.47Sevasemten
CAS:<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Formula:C16H11F4N5O2Color and Shape:SolidMolecular weight:381.28PF-03814735
CAS:<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Formula:C23H25F3N6O2Purity:98%Color and Shape:SolidMolecular weight:474.48CMX-2043
CAS:<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Formula:C16H26N2O6S2Purity:98%Color and Shape:SolidMolecular weight:406.52
