Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1382 products of "Cytoskeletal Signaling"
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Pavurutamab
CAS:<p>Pavurutamab (AMG-701) is a bispecific T cell engager targeting CD3 and BCMA with extended half-life, designed to treat MM.</p>Color and Shape:Liquid17-AEP-GA
CAS:<p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>Formula:C34H50N4O8Purity:97.77% - 99.56%Color and Shape:SolidMolecular weight:642.78Tubulin polymerization-IN-2
CAS:<p>Tubulin-IN-2, anticancer β-tubulin binder, IC50 0.92 μM, effective against various cancers.</p>Formula:C17H12F2N2O2Color and Shape:SolidMolecular weight:314.29Meclofenamic acid
CAS:<p>Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.</p>Formula:C14H11Cl2NO2Purity:98%Color and Shape:SolidMolecular weight:296.15SB273005
CAS:<p>SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.</p>Formula:C22H24F3N3O4Purity:99.58%Color and Shape:SolidMolecular weight:451.44N-Desmethylnefopam
CAS:<p>N-Desmethylnefopam is the main Nefopam metabolite .</p>Formula:C16H17NOPurity:98%Color and Shape:SolidMolecular weight:239.31Ionomycin calcium
CAS:<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>Formula:C41H70CaO9Purity:98% - 98.11%Color and Shape:SolidMolecular weight:747.07Phorbol 12,13-dibutyrate
CAS:<p>Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.</p>Formula:C28H40O8Purity:99.32% - 99.37%Color and Shape:SolidMolecular weight:504.61D-GsMTx4 TFA
<p>D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.</p>Formula:C187H279F3N48O48S6Purity:99.29% - 99.65%Color and Shape:SoildMolecular weight:4216.93IPA-3
CAS:<p>IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).</p>Formula:C20H14O2S2Purity:97.40%Color and Shape:SolidMolecular weight:350.45Tirofiban
CAS:<p>Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.</p>Formula:C22H36N2O5SPurity:99.83%Color and Shape:SolidMolecular weight:440.6Auristatin F
CAS:<p>Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.</p>Formula:C40H67N5O8Purity:98.41% - 99.25%Color and Shape:SolidMolecular weight:745.99Mps1-IN-1
CAS:<p>Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )</p>Formula:C28H33N5O4SPurity:98.33%Color and Shape:SolidMolecular weight:535.66BAY1217389
CAS:<p>BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).</p>Formula:C27H24F5N5O3Purity:98.14% - 99.42%Color and Shape:SolidMolecular weight:561.5AS1938909
CAS:<p>AS1938909: SHIP2 inhibitor boosts Akt phosphorylation, glucose use, and uptake via GLUT1 in L6 myotubes.</p>Formula:C19H13Cl2F2NO2SPurity:98%Color and Shape:SolidMolecular weight:428.28IQTub4P
CAS:<p>IQTub4P is a potent inhibitor of microtubules. IQTub4P exhibits cytotoxicity in HeLa cells (EC50: 170 nM).</p>Formula:C19H18NNa2O8PColor and Shape:SolidMolecular weight:465.305HSP90-IN-14
CAS:<p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>Formula:C14H8Cl2N4O4SColor and Shape:SolidMolecular weight:399.21Microtubule inhibitor 4
CAS:<p>Microtubule inhibitor 4 (Compound 2) blocks polymerization, toxic to HT-29 cells (IC50: 2.1 nM).</p>Formula:C25H23FN4O3Color and Shape:SolidMolecular weight:446.47NC9 TG2 inhibitor
CAS:<p>NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).</p>Formula:C35H47N5O8SPurity:98%Color and Shape:SolidMolecular weight:697.84Antiproliferative agent-30
CAS:<p>Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against</p>Formula:C24H26N4O4Color and Shape:SolidMolecular weight:434.49Tubulin polymerization-IN-42
CAS:<p>Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, inhibits tubulin polymerization and exhibits anti-cancer properties [1].</p>Formula:C22H21NO5Color and Shape:SolidMolecular weight:379.41CCT251236
CAS:<p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>Formula:C32H32N4O5Purity:98.82% - 99.89%Color and Shape:SolidMolecular weight:552.62GR 144053 trihydrochloride
CAS:<p>platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist</p>Formula:C18H30Cl3N5O2Purity:98%Color and Shape:SolidMolecular weight:454.82Alyssin
CAS:<p>Alyssin: sulforaphane analog, antioxidant; boosts Nrf2 and phase II enzymes in cancer cells; lowers PAH metabolism, reducing cancer risk in vitro.</p>Formula:C7H13NOS2Purity:98%Color and Shape:SolidMolecular weight:191.31CH5164840
CAS:<p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>Formula:C19H23N5O2SColor and Shape:SolidMolecular weight:385.48Tubulozole
CAS:<p>Tubulozole blocks mitosis by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis.</p>Formula:C23H23Cl2N3O4SPurity:98%Color and Shape:SolidMolecular weight:508.42SEW84
CAS:<p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>Formula:C19H14F4N4OSColor and Shape:SolidMolecular weight:422.4Hsp90-Cdc37-IN-1
CAS:<p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>Formula:C43H57FN2O6SPurity:98%Color and Shape:SolidMolecular weight:748.99PP2A Cancerous-IN-1
CAS:<p>PP2A Cancerous-IN-1 is a potent inhibitor of CIP2A (Cancerous inhibitor of PP2A) and p-Akt that exhibits potent anti-proliferative effects.</p>Formula:C30H24N4O3Color and Shape:SolidMolecular weight:488.54OXi8007
CAS:<p>OXi8007, a water-soluble prodrug for OXi8006, disrupts vasculature and exhibits strong cytotoxicity against DU-145 cancer cells.</p>Formula:C26H24NNa2O10PColor and Shape:SolidMolecular weight:587.428Hsp90-IN-17
CAS:<p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>Formula:C21H20N4O7Color and Shape:SolidMolecular weight:440.41Chrysotobibenzyl
CAS:<p>Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.</p>Formula:C19H24O5Color and Shape:SolidMolecular weight:332.39Hydromethylthionine HBr
CAS:<p>Hydromethylthionine (LMTM/Leucomethylene Blue) inhibits tau in Alzheimer's/frontotemporal dementia and improves brain function.</p>Formula:C16H21Br2N3SColor and Shape:SolidMolecular weight:447.233CHPG
CAS:<p>CHPG is a selective mGluR5 agonist protects against traumatic brain injury.activates the ERK and Akt pathways, It also alleviates LPS-induced inflammation.</p>Formula:C8H8ClNO3Purity:98%Color and Shape:SolidMolecular weight:201.61Heat Shock Protein Inhibitor II
CAS:<p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>Formula:C12H11NO3Color and Shape:SolidMolecular weight:217.22Tau-aggregation-IN-1
CAS:<p>Tau-aggregation-IN-1 is a dopamine D2 and D3 receptor agonist and an inhibitor of tau441 protein aggregation (IC50: 21 μM).</p>Formula:C28H37N5O2SColor and Shape:SolidMolecular weight:507.69AK963
CAS:<p>AK963 (40708899) is a powerful PAK1 inhibitor reducing gastric cancer cell growth via the PAK1-NFκB-CyclinB1 pathway.</p>Formula:C16H18N2OColor and Shape:SolidMolecular weight:254.33(R)-TTBK1-IN-1
CAS:<p>(R)-TTBK1-IN-1: potent, selective brain-penetrant TTBK1 inhibitor, studies Alzheimer’s & tauopathies.</p>Formula:C18H19N5O2Color and Shape:SolidMolecular weight:337.38BMS-688521
CAS:<p>BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.</p>Formula:C26H19Cl2N5O4Purity:98.87%Color and Shape:SolidMolecular weight:536.37Syntelin
CAS:<p>Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.</p>Formula:C21H20N6O2S3Color and Shape:SolidMolecular weight:484.62LS-104
CAS:<p>LS-104 is a JAK2 inhibitor.</p>Formula:C19H16N2O3Color and Shape:SolidMolecular weight:320.34Tubulin polymerization-IN-25
CAS:<p>Tubulin polymerization-IN-25 inhibits tubulin (IC50: 1.11 μM) & FTase (IC50: 0.39 μM), and is cytotoxic to cancer cells, halting growth.</p>Formula:C24H18N2O3SColor and Shape:SolidMolecular weight:414.48AKT-IN-8
CAS:<p>AKT-IN-8 is a potent inhibitor of AKT, acting on AKT1 (IC50: 4.46 nM), AKT2 (IC50: 2.44 nM) and AKT3 (IC50: 9.47 nM).</p>Formula:C22H25ClN6O3Color and Shape:SolidMolecular weight:456.93AKT-IN-5
CAS:<p>AKT-IN-5, an Akt inhibitor, targets Akt1/Akt2 with IC50s: 450/400 nM.</p>Formula:C23H20N4O2Color and Shape:SolidMolecular weight:384.43Zalunfiban
CAS:<p>RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.</p>Formula:C16H18N8O2SColor and Shape:SolidMolecular weight:386.43cemadotin free base
CAS:<p>Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks</p>Formula:C35H56N6O5Purity:98.70% - 99.64%Color and Shape:SolidMolecular weight:640.86Zarilamide
CAS:<p>Zarilamide disrupts microtubules, inhibiting mitosis in Phytophthora capsici zoospore cysts.</p>Formula:C11H11ClN2O2Color and Shape:SolidMolecular weight:238.67Tubulin polymerization-IN-20
CAS:<p>Tubulin aggregation-IN-20, a potent inhibitor, may be studied for breast and drug-resistant colon cancers.</p>Formula:C25H24FNO5Color and Shape:SolidMolecular weight:437.46Tubulin/MMP-IN-1
<p>Tubulin/MMP-IN-1 inhibits tubulin, MMP, and cancer cell growth; disrupts cell cycles and induces apoptosis.</p>Formula:C38H44NO9PColor and Shape:SolidMolecular weight:689.73HSP90-IN-20
CAS:<p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>Formula:C26H32N4O4Color and Shape:SolidMolecular weight:464.56
