Deuterated Compounds

<p>Applications 1-Iodopentane-5,5,5-d3 (CAS# 920502-31-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Pentanone-d6 is labelled 3-Pentanone (P273600) which is a simple, symmetrical dialkyl ketone. It is mainly used as a solvent in paint and a precursor to vitamin E. It is a useful synthetic intermediate. It can be used as a reagent to synthesize Ethyl 2-Cyano-3,3-diethylacrylate (E907600) by Knoevenagel condensation. It also shows anticonvulsant effect in several types of mouse seizure models.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hasebe, N., et al.: Eur. J. Pharma., 642, 66 (2010); Siegel, H., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2002)<br></p>

<p>Applications Sodium Methanesulfonate-d3,13C is an intermediate used in the synthesis of Methanesulfonyl Chloride-d3,13C (M258847), which is a labeled analogue of Methanesulfonyl Chloride (M258845). Methanesulfonyl Chloride used in the synthesis of phosphodiesterase 9A Inhibitors, used in treatments for Alzheimer’s disease. It is also used in the preparation of sulfonamide derivatives showing antibacterial activity.<br>References Reddy, N. et al.: J. Chem. Sci., 124, 723 (2012); Claffey, M. et al.: J. Med. Chem., 55, 9055 (2012);<br></p>

<p>Applications 1,2,3,4-Tetramethylbenzene-d14 (CAS# 350818-60-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,4'-Dimethoxybenzophenone-d8 (rings-d8) (CAS# 350818-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzyl-d7-amine HCl (CAS# 352431-27-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Ethylhexanoic-d15 Acid (CAS# 352431-38-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Octanoate-d15 (CAS# 1219798-91-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled N-1-Naphthylethylenediamine Dihydrochloride, is an organic building block used for the chemical synthesis. It can also be used as highly selective organic fluorescent probe for azide ion.<br>References Sahana, A., et al.: Analyst , 137, 1544 (2012);<br></p>

<p>Applications Homotaurine-d6 is the isotope labelled analog of Homotaurine (H656200). Homotaurine is an important GABA mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid.<br>References Riv. Farmacol. Ter., 7, 155 (1976), Neuropharmacology, 17, 13 (1978), Br. J. Pharmacol., 59 373 (1977)<br></p>

<p>Applications Succinic Acid (D6, 98%) (cas# 21668-90-6) is a useful research chemical.<br></p>

<p>Applications Clemastine N-Oxide-d5 is the isotope labelled analog of Clemastine N-Oxide (C568505); a metabolite of Clemastine Fumarate (C568500) which is a H1 histamine receptor antagonist and antihistaminic.<br>References Froehlich, L., et al.: Pharmazie, 51, 409 (1996); Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967); Gober, B., et al.: Pharmazie, 43, 539 (1988); Breccia, A., et al.: Curr. Ther. Res., 49, 622 (1991); Schran, H., et al.: J. Clin. Pharmacol., 36, 911 (1996)<br></p>

<p>Applications Ammonium Formate-d5 (CAS# 65387-23-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Tolyl-d7 Isocyanate (CAS# 1219802-73-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl Oxalacetate-13C4 is an intermediate used in the synthesis of (O845032), which is labelled form of Oxaloacetic Acid (O845030) which is a four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.<br>References Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);<br></p>

<p>Applications 4-Cholesten-3-one-3,4-13C2 (CAS# 82938-09-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Phenylpropane-d12 (CAS# 97732-82-6) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Chlorotoluene-2,4,6-d3 (CAS# 1219803-79-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chlorophenyl Phenyl-d5 Ether (CAS# 93951-85-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,4-d2 (CAS# 1684-46-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-11,11,12,12-d4 Acid (CAS# 75736-57-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Deuteroindole is a useful reagent in the preparation of deuterated labeled indoles.<br>References Lautie, M. F., et al.: J. Label. Compd. Radiopharm., 16, 735 (1979); Ibaceta-Lizana, J. S. L., et al.: J. Chem. Soc. Perkin Trans 2., 9, 1221 (1987)<br></p>

<p>Applications 2,2,2-Trichloroethanol-13C2,D2 (cas# 1216995-48-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethylene Glycol Monolaurate-d4 is a deuterated analog of Ethylene Glycol Monolaurate (E917585), a reactant in the synthesis of neuritogenic gentiside derivatives.<br>References Wang, Guangfa, et al.: Chem. &amp; Pharma. Bul., 64(2), 161-170 (2016)<br></p>

<p>Applications Anthracene-d10 is an isotope labelled analogue of Anthracene (A678400), an polycyclic aromatic hydrocarbon found readily as an component in coal tar. Anthracene is also used in the preparation of various dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diethyl-d10-amine HCl (CAS# 285132-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Diisopropylamine-d14 is used in the synthesis of trideuterated propantheline bromide;Also, it is an intermediate used in the synthesis of Disopyramide-d14 Tosylate Salt (D493452), which is an anti-arrhythmic (class IA). Sodium channel blocker.<br>References Buckley, P. H., et al.: J. Label. Compd. Radiopharm., 15, 657-664 (1978); Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986)<br></p>

<p>Applications N-Acetyl-DL-alanine-3,3,3-d3 is an isotopic analog of N-Acetyl-DL-alanine (A167965), a derivative of DL-Alanine (A481400) and is used as a reagent in the synthesis of potent new agents for the treatment of epilepsy.<br>References Conley, J.D., et al.: J. Med. Chem., 30, 567 (1987)<br></p>

<p>Applications Benzyl-2,3,4,5,6-D5 Alcohol is an isotopically labeled analog of Benzyl Alcohol (T536635), which is used in the synthesis of Cephalosporolide B as a versatile biomimetic synthetic precursor for chemical synthesis of other cephalosporides.<br>References Song, L. et al.: Org. Lett., 15, 5850 (2013);<br></p>

<p>Applications Estradiol 17-Palmitate-d31 is the isotope analog of Estradiol 17-Palmitate. Estradiol 17-Palmitate is a metabolite of estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987),<br></p>

<p>Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications Choline-d13 Bromide (cas# 203645-64-1) is a useful research chemical.<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester-d4 is the isotope labelled analog of Phthalic Acid Bis(3,7-dimethyloctyl) Ester (P384535); a diester derivative of Phthalic Acid (P384480) which can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications Heptyl 5-Methyl-2-hexyl Phthalate-d4, is the labeled analogue of Heptyl 5-Methyl-2-hexyl Phthalate, a phthalate ester used as plasticizers and additives.<br>References Peterson, J.C., et al.: Int. J. Envrion. Anal. Chem., 18, 237 (1984);<br></p>

<p>Applications 5-Bromo-5-nitro-1,3-dioxane-d6 is the labelled analogue of 5-Bromo-5-nitro-1,3-dioxane (B697990), which is used in pest control in domestic textile hygiene, and is also commonly found in cosmetics.<br>References Sanchez-P, L., et al.: Anal. Bioanal. Chem., 401, 3293-04 (2011); Travassos, A.R., et al.: Contact Dermatitis, 65, 276-85 (2011);<br></p>

<p>Applications N-2-Hydroxyethyl-N-(methyl-d3)-p-toluenesulfonamide (cas# 854634-39-2) is a compound useful in organic synthesis.<br>References du Vigneaud, V., et al.: J. Biol. Chem., 164, 603 (1946),<br></p>

<p>Applications Octadecanoic-2,2-d2 Acid (CAS# 19905-58-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Acetyl-d3 Rocuronium Bromide is the isotope labelled analog of 3-Acetyl Rocuronium Bromide (A187730); an impuritiy of Rocuronium Bromide (R639500) which is an aminosteroid and a competitive neuromuscular blocker.<br>References Srinivasan, N., et al.: Oriental. J. Chem., 24, 989 (2008); Magorian, T., et al.: Anesthesiology, 79, 913 (1993); Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)<br></p>

<p>Applications Butyric-3,3-d2 Acid (CAS# 64833-96-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Des[(5-Methyl-1,3,4-thiadiazol-2-yl)thio] Cefazolin-3-methanol is an impurity of Cefazolin (C242500). Cefazolin impurity X3.<br>References Kidwai, M., et al.: Chem. Lett., 6, 487 (1999), Kidwai, M., et al.: Bioorg. Med. Chem., 8, 69 (2000),<br></p>

<p>Applications Labelled Dibenzo[a,l]pyrene (D416945). An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dibenzo[def,p]chrysene (DBC) is a carcinogen and should be handled with appropriate caution.<br>References Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007),<br></p>

<p>Applications Propionitrile-d5 (CAS# 10419-75-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,4,5-Benzenetetracarboxylic Acid-d6 (CAS# 344298-79-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl (Z)-Geranate-d6 is an intermediate in synthesizing Geraniol-D5 (G367003), a deuterium labelled analog of Geraniol. It is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>

<p>Applications p-Toluidine-d9 (CAS# 352431-23-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cholic Acid-24-13C (CAS# 52886-36-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Hexyl-1,1-d2 Alcohol (CAS# 52598-04-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxypiperidine-D4 is an isotope labelled form of 4-Hydroxypiperidine (H950845), a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999);<br></p>

<p>Applications Methyliminodiacetic-d4 Acid (CAS# 1219803-27-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzo[b]thien-2-yl ketone-D10 is a labelled analogue of Benzo[b]thien-2-yl ketone (B207710). Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. &amp; Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>

<p>Applications 2-Bromopropane-1,1,1,2-d4 (CAS# 1219799-22-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 8-Bromo-3,7-dihydro-3-methyl-7-(1-methylethyl)-1H-purine-2,6-dione-d7, is the labeled analogue of (B683490), which is a substituted derivative of Xanthine (X499950).<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>

<p>Applications 1-Isopropyl-d7-piperazine (CAS# 2089679-76-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Bromoaniline-d4 is the labeled analogue of 2-Bromoaniline (B679950), a reagent used in the synthesis of substituted 2-carboxanilides as herbicides and antibacterials. Also used in the synthesis of benzisothiazol-3-one derivatives as caspase-3 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kos, J. et al.: Molecules, 18, 7977 (2013); Liu, D. et al.: Bioorg. Med. Chem., 21, 2960 (2013)<br></p>

<p>Applications 2,3-Dimethylphenol-13C4 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)<br></p>

<p>Applications 2-Chlorotoluene-d7 (CAS# 84344-05-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Dibromobenzene (D4, 98%) (cas# 4165-56-4) is a useful research chemical.<br></p>

<p>Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.<br>References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.<br></p>

<p>Applications Isotope labelled Cyclopropylmethyl Bromide is a reagent used in the synthesis of human dihydroorotate dehydrogensase inhibitors which are based on azole scaffolds. In addition it is used in the preparation of ([11C]CMDC) for PET imaging of mGlur2 which has been a proposed target in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainas, S. et al.: Eur. J. Med. Chem., 129, 287 (2017); Ma, Y. et al.: Bioorg. Med. Chem., 25, 1014 (2017);<br></p>

<p>Applications n-Butyl-4,4,4-d3-benzene (CAS# 109232-94-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropyl-d5-boronic Acid is a deuterated version of Cyclopropylboronic Acid (C988620), an organoboronic acid commonly used in highly efficient Suzuki coupling reactions.<br>References Ma, S. et al.: Adv. Synth. Cat., 348, 2114 (2006)<br></p>

<p>Applications 3-Aminopropionamide-2,2,3,3-d4 HCl (CAS# 1276197-35-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methylurea-d6 is the labelled form of N-Methylurea (M338175). N-Methylurea is used as a reagent in the synthesis of bis(aryl)(hydroxyalkyl)(methyl)glycoluril derivatives and is a potential byproduct of caffeine.<br>References Antonova, M.M., et al.: Chem. Heterocycl. Comp., 50, 503 (2014); Zarrelli, A., et al.: Sci. Total Environ., 470, 453 (2014)<br></p>

<p>Applications 3-Chlorobenzoic-d4 Acid (CAS# 2098655-72-0) is a useful isotopically labeled research compound. The compound can be used to prepare isotopically enriched analogs for treating and preventing thrombosis.<br>References Pandey, A., et.al., PCT Int. Appl., 51,(2017);<br></p>